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Conversion of aldoses to valuable ?-amino alcohols using amine transaminase biocatalysts (2018)
Journal Article
Cairns, R., Gomm, A., Ryan, J., Clarke, T., Kulcinskaja, E., Butler, K., & O’Reilly, E. (2019). Conversion of aldoses to valuable ω-amino alcohols using amine transaminase biocatalysts. ACS Catalysis, 9(2), 1220-1223. https://doi.org/10.1021/acscatal.8b04564

The conversion of readily available monosaccharides to high-value amino alcohols using a key biocatalytic step is an attractive strategy for the preparation of these chiral synthons. Here, we report a previously undescribed example of the direct ami... Read More about Conversion of aldoses to valuable ?-amino alcohols using amine transaminase biocatalysts.

Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations (2018)
Journal Article
Gomm, A., Grigoriou, S., Peel, C., Ryan, J., Mujtaba, N., Clarke, T., …O'Reilly, E. (2018). Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations. European Journal of Organic Chemistry, 2018(38), 5282-5284. https://doi.org/10.1002/ejoc.201800799

The 'smart' amine donors o‐xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative‐scale synthesis of selected compounds using the commercially available amine transaminase, ATA256. Th... Read More about Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations.