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All Outputs (10)

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study (2018)
Journal Article
Shrine, N., Portelli, M. A., John, C., Soler Artigas, M., Bennett, N., Hall, R., …Sayers, I. (2019). Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. Lancet Respiratory Medicine, 7(1), 20-34. https://doi.org/10.1016/S2213-2600%2818%2930389-8

Background Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribut... Read More about Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma. (2018)
Journal Article
Brinkman, P., Wagener, A. H., Hekking, P., Bansal, A. T., Maitland-van der Zee, A., Wang, Y., …Study Group, U. (2019). Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma. Journal of Allergy and Clinical Immunology, 143(5), 1811-1820. https://doi.org/10.1016/j.jaci.2018.10.058

Background: Severe asthma is a heterogeneous condition, as shown by independent cluster analyses based on demographic, clinical, and inflammatory characteristics. A next step is to identify molecularly driven phenotypes using “omics” technologies. Mo... Read More about Identification and prospective stability of electronic nose (eNose)-derived inflammatory phenotypes in patients with severe asthma..

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort (2018)
Journal Article
Emma, R., Bansal, A. T., Kolmert, J., Wheelock, C. E., Dahlen, S., Loza, M. J., …U-BIOPRED Study Group. (2018). Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort. PLoS ONE, 13(9), 1-16. https://doi.org/10.1371/journal.pone.0203874

Oxidative stress is believed to be a major driver of inflammation in smoking asthmatics. The U-BIOPRED project recruited a cohort of Severe Asthma smokers/ex-smokers (SAs/ex) and non-smokers (SAn) with extensive clinical and biomarker information ena... Read More about Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort.

Investigating the discriminative value of Early Warning Scores in patients with respiratory disease using a retrospective cohort analysis of admissions to Nottingham University Hospitals Trust over a 2-year period (2018)
Journal Article
Forster, S., Housley, G., McKeever, T. M., & Shaw, D. E. (2018). Investigating the discriminative value of Early Warning Scores in patients with respiratory disease using a retrospective cohort analysis of admissions to Nottingham University Hospitals Trust over a 2-year period. BMJ Open, 8(7), Article e020269. https://doi.org/10.1136/bmjopen-2017-020269

Objective: Early Warning Scores (EWSs) are used to monitor patients for signs of imminent deterioration. Although used in respiratory disease, EWSs have not been well studied in this population, despite the underlying cardiopulmonary pathophysiology... Read More about Investigating the discriminative value of Early Warning Scores in patients with respiratory disease using a retrospective cohort analysis of admissions to Nottingham University Hospitals Trust over a 2-year period.

Impact of straight to test pathways on time to diagnosis in oesophageal and gastric cancer (2018)
Journal Article
Jones, J. A., Catton, J., Howard, G., Leeder, P., Brewer, L., Hatton, J., & Shaw, D. E. (2018). Impact of straight to test pathways on time to diagnosis in oesophageal and gastric cancer. BMJ Open Quality, 7(3), e000328. https://doi.org/10.1136/bmjoq-2018-000328

Background: Cancer survival in the UK has doubled in the last 40 years; however, 1-year and 5-year survival rates are still lower than other countries. One cause may be a delay between referral into secondary care and subsequent investigation. We set... Read More about Impact of straight to test pathways on time to diagnosis in oesophageal and gastric cancer.

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation (2018)
Journal Article
Jevnikar, Z., Östling, J., Ax, E., Calvén, J., Thörn, K., Israelsson, E., …Olsson, H. K. (in press). Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation. Journal of Allergy and Clinical Immunology, https://doi.org/10.1016/j.jaci.2018.05.026

Background: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) with asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthma is unclear. Objective: To explore the association... Read More about Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.

Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis (2018)
Journal Article
Takahashi, K., Pavlidis, S., Ng Kee Kwong, F., Hoda, U., Rossios, C., Sun, K., …Chung, K. F. (2018). Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis. European Respiratory Journal, 51(5), https://doi.org/10.1183/13993003.02173-2017

Background: Severe asthma patients with a significant smoking history have airflow obstruction with reported neutrophilia. We hypothesise that multi-omic analysis will enable the definition of smoking and ex-smoking severe asthma molecular phenotypes... Read More about Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis.

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial (2018)
Journal Article
Hanratty, C. E., Matthews, J. G., Arron, J. R., Choy, D. F., Pavord, I. D., Bradding, P., …Heaney, L. G. (2018). A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial. Trials, 19, Article 5. https://doi.org/10.1186/s13063-017-2384-7

Background: Patients with difficult-to-control asthma consume 50–60% of healthcare costs attributed to asthma and cost approximately five-times more than patients with mild stable disease. Recent evidence demonstrates that not all patients with asthm... Read More about A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial.