All Outputs (24)

Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle (2017)
Journal Article
Dai, Y., Ivell, R., & Anand-Ivell, R. (2017). Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle. Frontiers in Physiology, 8, https://doi.org/10.3389/fphys.2017.01033

Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedione. Using... Read More about Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle.

Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis (2017)
Journal Article
Corr, S. A., Gardner, D. S., Langley-Hobbs, S., Ness, M. G., Kitchener, A. C., & Sinclair, K. D. (2017). Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis. Scientific Reports, 7, Article 15685. https://doi.org/10.1038/s41598-017-15902-8

Our recent report detailing the health status of cloned sheep concluded that the animals had aged normally. This is in stark contrast to reports on Dolly (first animal cloned from adult cells) whose diagnoses of osteoarthritis (OA) at 5½ years of age... Read More about Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis.

A longitudinal study of gastrointestinal parasites in English dairy farms: practices and factors associated with first lactation heifer exposure to Ostertagia ostertagi on pasture (2017)
Journal Article
Bellet, C., Green, M. J., Bradley, A. J., & Kaler, J. (2018). A longitudinal study of gastrointestinal parasites in English dairy farms: practices and factors associated with first lactation heifer exposure to Ostertagia ostertagi on pasture. Journal of Dairy Science, 101(1), https://doi.org/10.3168/jds.2017-12952

The gastrointestinal nematode Ostertagia ostertagi is an important cause of lost production, health, and welfare in cattle. Detailed records were obtained over a 5-yr period (2010–2015) by questionnaires and qualitative interviews to investigate the... Read More about A longitudinal study of gastrointestinal parasites in English dairy farms: practices and factors associated with first lactation heifer exposure to Ostertagia ostertagi on pasture.

Neohormones in milk (2017)
Journal Article
Ivell, R., & Anand-Ivell, R. (2017). Neohormones in milk. Best Practice and Research: Clinical Endocrinology and Metabolism, 31(4), https://doi.org/10.1016/j.beem.2017.10.005

Neohormone systems evolved specifically to regulate those mammalian traits, such as internal fertilization, pregnancy and lactation, which have proved to be central to the success, environmental independence, and adaptability of mammals as a vertebra... Read More about Neohormones in milk.

Effects of insulin like growth factors on early embryonic chick limb myogenesis (2017)
Journal Article
Mohammed, R. H., Anderton, H., Brameld, J. M., & Sweetman, D. (2017). Effects of insulin like growth factors on early embryonic chick limb myogenesis. PLoS ONE, 12(10), Article e0185775. https://doi.org/10.1371/journal.pone.0185775

Limb muscles derive from pax3 expressing precursor cells that migrate from the hypaxial somite into the developing limb bud. Once there they begin to differentiate and express muscle determination genes such as MyoD. This process is regulated by a co... Read More about Effects of insulin like growth factors on early embryonic chick limb myogenesis.

Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin (2017)
Journal Article
Zeebaree, B. K., Kwong, W. Y., Mann, G. E., Gutierrez, C. G., & Sinclair, K. D. (2018). Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin. Theriogenology, 105, https://doi.org/10.1016/j.theriogenology.2017.09.014

Our understanding of the effects of temperature on granulosa cell (GC) physiology is primarily limited to in vitro studies conducted under atmospheric (approx 20% O2) conditions. In the current series of factorial experiments we identify important ef... Read More about Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin.

Sponsorship bias and quality of randomised controlled trials in veterinary medicine (2017)
Journal Article
Wareham, K., Hyde, R., Grindlay, D. J., Brennan, M. L., & Dean, R. S. (in press). Sponsorship bias and quality of randomised controlled trials in veterinary medicine. BMC Veterinary Research, 13(234), https://doi.org/10.1186/s12917-017-1146-9

Background: Randomised controlled trials (RCTs) are considered the gold standard form of evidence for assessing treatment efficacy, but many factors can influence their reliability including methodological quality, reporting quality and funding sourc... Read More about Sponsorship bias and quality of randomised controlled trials in veterinary medicine.

Opinions of UK rescue shelter and rehoming center workers on the problems facing their industry (2017)
Journal Article
Stavisky, J., Brennan, M. L., Downes, M. J., & Dean, R. S. (in press). Opinions of UK rescue shelter and rehoming center workers on the problems facing their industry. Anthrozoös, 30(3), https://doi.org/10.1080/08927936.2017.1326677

Animal shelters exist worldwide to care for and rehome unwanted or straying pets. Previous studies have examined why owners breed unwanted animals, or relinquish their pets to shelters. However, the views of shelter workers, who receive and care for... Read More about Opinions of UK rescue shelter and rehoming center workers on the problems facing their industry.

Evaluation of vegetable protein in canine diets: assessment of performance and apparent ileal amino acid digestibility using a broiler model (2017)
Journal Article
Fiacco, D., Lowe, J., Wiseman, J., & White, G. (in press). Evaluation of vegetable protein in canine diets: assessment of performance and apparent ileal amino acid digestibility using a broiler model. Journal of Animal Physiology and Animal Nutrition, https://doi.org/10.1111/jpn.12764

Recent technological advances in the human food industry with respect to meat processing have decreased the availability of animal proteins to the pet food industry which typically formulates diets with an excess of animal protein. In the long term,... Read More about Evaluation of vegetable protein in canine diets: assessment of performance and apparent ileal amino acid digestibility using a broiler model.

Ovine recombinant PrP as an inhibitor of ruminant prion propagation in vitro (2017)
Journal Article
Maddison, B. C., Workman, R. G., & Gough, K. C. (in press). Ovine recombinant PrP as an inhibitor of ruminant prion propagation in vitro. Prion, 11(4), https://doi.org/10.1080/19336896.2017.1342919

Prion diseases are fatal and incurable neurodegenerative diseases of humans and animals. Despite years of research, no therapeutic agents have been developed that can effectively manage or reverse disease progression. Recently it has been identified... Read More about Ovine recombinant PrP as an inhibitor of ruminant prion propagation in vitro.

Understanding the direct and indirect mechanisms of xylanase action on starch digestion in broilers (2017)
Journal Article
Lee, S. A., Wiseman, J., Masey O’Neill, H. V., Scholey, D. V., Burton, E. J., & Hill, S. E. (2017). Understanding the direct and indirect mechanisms of xylanase action on starch digestion in broilers. Journal of World's Poultry Research, The, 7(2),

The objective of the current study was to investigate the mechanisms of xylanase action in a maize-soya diet and its effect on starch digestion. A total of 60 broilers were divided into 6 treatment groups; a control group without xylanase, and five o... Read More about Understanding the direct and indirect mechanisms of xylanase action on starch digestion in broilers.

Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus (2017)
Journal Article
Glynn, D. J., Heng, K., Russell, D. L., Sharkey, D. J., Robertson, S. A., Anand-Ivell, R., & Ivell, R. (2017). Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus. Frontiers in Physiology, 8, Article 422. https://doi.org/10.3389/fphys.2017.00422

The hormone relaxin is important in female reproduction for embryo implantation, cardiovascular function, and during labor and lactation. Relaxin is also synthesized in males by organs of the male tract. We hypothesized that relaxin might be one comp... Read More about Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus.

Principles of early human development and germ cell program from conserved model systems (2017)
Journal Article
Kobayashi, T., Zhang, H., Tang, W., Irie, N., Withey, S., Klisch, D., …Surani, M. (2017). Principles of early human development and germ cell program from conserved model systems. Nature, 546, https://doi.org/10.1038/nature22812

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during week 2-3 of early postimplantation development(1). Using in vitro models of hPGC induction(2-4), recent studies suggest striking mechanistic differences in specif... Read More about Principles of early human development and germ cell program from conserved model systems.

Relaxin-family peptide receptors 1 and 2 are fully functional in the bovine (2017)
Journal Article
Dai, Y., Ivell, R., Liu, X., Janowski, D., & Anand-Ivell, R. (2017). Relaxin-family peptide receptors 1 and 2 are fully functional in the bovine. Frontiers in Physiology, 8, Article 359. https://doi.org/10.3389/fphys.2017.00359

In most mammals the peptide hormone relaxin is a key physiological component regulating early pregnancy and birth. However, synteny analysis shows that the gene encoding ovarian relaxin-2 is deleted in cows and sheep. While, these ruminants appear to... Read More about Relaxin-family peptide receptors 1 and 2 are fully functional in the bovine.

The efficacy of supplying supplemental cobalt, selenium and vitamin B?? via the oral drench route in sheep (2017)
Journal Article
Williams, J. R., Williams, N. E., & Kendall, N. R. (in press). The efficacy of supplying supplemental cobalt, selenium and vitamin B?? via the oral drench route in sheep. Livestock Science, 200, https://doi.org/10.1016/j.livsci.2017.04.010

Cobalt and selenium are essential trace elements required for ruminants. There are many different methods of supplementation available to sheep including boluses, in feed, free access minerals, pasture dressing and oral drenches. Recent changes in Eu... Read More about The efficacy of supplying supplemental cobalt, selenium and vitamin B?? via the oral drench route in sheep.

Mouse mitochondrial lipid composition is defined by age in brain and muscle (2017)
Journal Article
Pollard, A. K., Ortori, C. A., Stöger, R., Barrett, D. A., & Chakrabarti, L. (in press). Mouse mitochondrial lipid composition is defined by age in brain and muscle. Aging, 9(3), https://doi.org/10.18632/aging.101204

Functionality of the lipid rich mitochondrial organelle declines with increased age. Recent advances in lipidomic technologies allowed us to perform a global characterisation of lipid composition in two different tissue types and age ranges. Ultra-hi... Read More about Mouse mitochondrial lipid composition is defined by age in brain and muscle.

Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection (2017)
Journal Article
Cong, W., Zhang, X., He, J., Li, F., Elsheikha, H. M., & Zhu, X. (2017). Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection. Oncotarget, 8(15), https://doi.org/10.18632/oncotarget.16108

Although microRNAs (miRNAs) play an important role in liver homeostasis, the extent to which they can be altered by Toxoplasma gondii infection is unknown. Here, we utilized small RNA sequencing and bioinformatic analyses to characterize miRNA expres... Read More about Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection.

Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders (2017)
Journal Article
Lee, J. L., Bertoglio, L. J., Guimaraes, F. S., & Stevenson, C. W. (in press). Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders. British Journal of Pharmacology, https://doi.org/10.1111/bph.13724

Learning to associate cues or contexts with potential threats or rewards is adaptive and enhances survival. Both aversive and appetitive memories are therefore powerful drivers of behaviour, but the inappropriate expression of conditioned responding... Read More about Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders.

Relaxin-like peptides in male reproduction: a human perspective (2017)
Journal Article
Ivell, R., Agoulnik, A. I., & Anand-Ivell, R. (2017). Relaxin-like peptides in male reproduction: a human perspective. British Journal of Pharmacology, 174(10), 990-1001. https://doi.org/10.1111/bph.13689

The relaxin family of peptide hormones and their cognate GPCRs are becoming physiologically well-characterized in the cardiovascular system and particularly in female reproductive processes. Much less is known about the physiology and pharmacology of... Read More about Relaxin-like peptides in male reproduction: a human perspective.

HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells (2017)
Journal Article
Shah, M., Cardenas, R., Wang, B., Persson, J., Mongan, N. P., Grabowska, A. M., & Allegrucci, C. (2017). HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Molecular Cancer, 16(38), https://doi.org/10.1186/s12943-017-0605-z

Background: Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissue... Read More about HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.