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All Outputs (46)

Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy (2017)
Journal Article
McTague, A., Nair, U., Malhotra, S., Meyer, E., Trump, N., Gazina, E. V., …Kurian, M. A. (2018). Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy. Neurology, 90(1), Article e1-e12. https://doi.org/10.1212/WNL.0000000000004762

Objective: To characterize the phenotypic spectrum, molecular genetic findings, and functional consequences of pathogenic variants in early-onset KCNT1 epilepsy. Methods: We identified a cohort of 31 patients with epilepsy of infancy with migrating... Read More about Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy.

The invasive region of glioblastoma defined by 5ALA guided surgery has an altered cancer stem cell marker profile compared to central tumour (2017)
Journal Article
Smith, S. J., Diksin, M., Chhaya, S., Sairam, S., Estevez-Cebrero, M. A., & Rahman, R. (2017). The invasive region of glioblastoma defined by 5ALA guided surgery has an altered cancer stem cell marker profile compared to central tumour. International Journal of Molecular Sciences, 18(11), https://doi.org/10.3390/ijms18112452

Glioblastoma, a WHO grade IV astrocytoma, is a highly aggressive and heterogeneous tumour that infiltrates deeply into surrounding brain parenchyma, making complete surgical resection impossible. Despite chemo-radiotherapy, the residual cell populati... Read More about The invasive region of glioblastoma defined by 5ALA guided surgery has an altered cancer stem cell marker profile compared to central tumour.

Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2þ/CaMKK2 Signaling to Enhance Tumor Cell Survival (2017)
Journal Article
Vara-Ciruelos, D., Dandapani, M., Gray, A., Egbani, E. O., Evans, A. M., & Hardie, D. G. (2018). Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2þ/CaMKK2 Signaling to Enhance Tumor Cell Survival. Molecular Cancer Research, 16(2), 345-357. https://doi.org/10.1158/1541-7786.mcr-17-0323

2017 American Association for Cancer Research. Many genotoxic cancer treatments activate AMP-activated protein kinase (AMPK), but the mechanisms of AMPK activation in response to DNA damage, and its downstream consequences, have been unclear. In this... Read More about Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2þ/CaMKK2 Signaling to Enhance Tumor Cell Survival.

The molecular and phenotypic basis of the glioma invasive perivascular niche (2017)
Journal Article
Diksin, M., Smith, S. J., & Rahman, R. (2017). The molecular and phenotypic basis of the glioma invasive perivascular niche. International Journal of Molecular Sciences, 18(11), Article 2342. https://doi.org/10.3390/ijms18112342

Gliomas are devastating brain cancers that have poor prognostic outcomes for their patients. Short overall patient survival is due to a lack of durable, efficacious treatment options. Such therapeutic difficulties exist, in part, due to several gliom... Read More about The molecular and phenotypic basis of the glioma invasive perivascular niche.

Variation in visiting and isolation policies in neonatal units: a UK nationwide survey (2017)
Journal Article
Tan, S., Clarkson, M., & Sharkey, D. (in press). Variation in visiting and isolation policies in neonatal units: a UK nationwide survey. Pediatric Infectious Disease Journal, https://doi.org/10.1097/INF.0000000000001820

Global pandemics, such as H1N1, are a major risk for neonatal patients. We surveyed UK tertiary and district neonatal units about visiting and infection control policies relating to viral respiratory infections. There was marked variation with visiti... Read More about Variation in visiting and isolation policies in neonatal units: a UK nationwide survey.

Metformin for endometrial hyperplasia (Review) (2017)
Journal Article
Clement, N. S., Oliver, T. R., Shiwani, H., Sanner, J. R., Mulvaney, C. A., & Atiomo, W. (2017). Metformin for endometrial hyperplasia (Review). Cochrane Database of Systematic Reviews, Article CD012214. https://doi.org/10.1002/14651858.CD012214.pub2

Background Endometrial cancer is one of the most common gynaecological cancers in the world. Rates of endometrial cancer are rising, in part because of rising obesity rates. Endometrial hyperplasia is a precancerous condition in women that can lead... Read More about Metformin for endometrial hyperplasia (Review).

Early respiratory bacterial detection and anti-staphylococcal antibiotic prophylaxis in young children with cystic fibrosis (2017)
Journal Article
Hurley, M., Fogarty, A. W., McKeever, T. M., Goss, C., Rosenfeld, M., & Smyth, A. R. (in press). Early respiratory bacterial detection and anti-staphylococcal antibiotic prophylaxis in young children with cystic fibrosis. Annals of the American Thoracic Society, https://doi.org/10.1513/AnnalsATS.201705-376OC

Rationale: Consensus is lacking regarding anti-staphylococcal antibiotic prophylaxis use for young children with cystic fibrosis. Prophylaxis is recommended in the UK, but recommended against in the US. Objectives: To test the hypothesis that anti-... Read More about Early respiratory bacterial detection and anti-staphylococcal antibiotic prophylaxis in young children with cystic fibrosis.

Investigating the mechanisms of endometrial cancer risk in polycystic ovary syndrome: can UK biobank help? (2017)
Journal Article
Atiomo, W., Lakshmi Karanam, V., Sian, M., & Grainge, M. (2017). Investigating the mechanisms of endometrial cancer risk in polycystic ovary syndrome: can UK biobank help?. Obstetrics & gynecology international journal, 8(1), Article 00277. https://doi.org/10.15406/ogij.2017.08.00277

Background: UK biobank was set up to investigate the respective contributions of genetic predisposition and environmental exposure to the development of disease and recruited participants between 2006 and 2010. Our aim was to investigate the feasibil... Read More about Investigating the mechanisms of endometrial cancer risk in polycystic ovary syndrome: can UK biobank help?.

Embryo cell allocation patterns are not altered by biopsy but can be linked with further development (2017)
Journal Article
Sepulveda-Rincon, L. P., Islam, N., Marsters, P., Campbell, B. K., Beaujean, N., & Maalouf, W. E. (in press). Embryo cell allocation patterns are not altered by biopsy but can be linked with further development. Reproduction, https://doi.org/10.1530/REP-17-0514

It has been suggested that first embryo cleavage can be related with the embryonic-abembryonic axis at blastocyst stage in mice. Thus, cells of the 2 cell embryo might be already biased to form the inner cell mass or trophectoderm. This study was con... Read More about Embryo cell allocation patterns are not altered by biopsy but can be linked with further development.

Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions (2017)
Journal Article
Chou, I., Lim, S., Tanasescu, R., Al-Radaideh, A., Mougin, O. E., Tench, C. R., …Constantinescu, C. S. (in press). Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions. Journal of Neuroimaging, https://doi.org/10.1111/jon.12474

BACKGROUND AND PURPOSE: Fluid-attenuated inversion recovery (FLAIR) imaging at 3 Tesla (T) field strength is the most sensitive modality for detecting white matter lesions in multiple sclerosis. While 7T FLAIR is effective in detecting cortical lesio... Read More about Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions.

Mapping midwifery and obstetric units in England (2017)
Journal Article
Walsh, D., Spiby, H., Grigg, C. P., Dodwell, M., McCourt, C., Culley, L., …Byers, S. (in press). Mapping midwifery and obstetric units in England. Midwifery, 56, https://doi.org/10.1016/j.midw.2017.09.009

Objective: to describe the configuration of midwifery units, both alongside&free-standing, and obstetric units in England. Design: national survey amongst Heads of Midwifery in English Maternity Services Setting: National Health Service (NHS) in En... Read More about Mapping midwifery and obstetric units in England.

Fetal Surveillance (2017)
Book Chapter
Kapoor, D., & Jones, N. (2017). Fetal Surveillance. In D. R. McCance, M. Maresh, & D. A. Sacks (Eds.), A Practical Manual of Diabetes in Pregnancy (243-255). (2nd). Wiley. https://doi.org/10.1002/9781119043805.ch19

Pregnancies in women with diabetes are associated with increased perinatal morbidity and mortality, even when the baby is structurally normal. The pathophysiology of this is poorly understood and likely to be multifactorial. The goal of surveillance... Read More about Fetal Surveillance.

Randomised trial of cord clamping and initial stabilisation at very preterm birth (2017)
Journal Article
Duley, L., Dorling, J., Pushpa-Rajah, A., Oddie, S. J., Yoxall, C. W., Schoonakker, B., …Fawke, J. A. (2018). Randomised trial of cord clamping and initial stabilisation at very preterm birth. Archives of Disease in Childhood. Fetal and Neonatal Edition, 103(1), F6-F14. https://doi.org/10.1136/archdischild-2016-312567

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. OBJECTIVES: For very preterm births, to compare alternative po... Read More about Randomised trial of cord clamping and initial stabilisation at very preterm birth.

Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging (2017)
Journal Article
Perez-Cota, F., Smith, R. J., Moradi, E., Leija, A. L., Velickovic, K., Marques, L., …Clark, M. (2017). Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging

The mechanical properties of cells play an important role in cell function and behavior. This paper presents recent developments that have enabled the use of laser-generated phonons (ultrasound) with sub-optical wavelengths to look inside living cell... Read More about Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging.

Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans (2017)
Journal Article
Law, J., Morris, D. E., Izzi Engbeaya, C., Salem, V., Coello, C., Robinson, L. J., …Symonds, M. E. (2018). Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans. Journal of Nuclear Medicine, 59(3), https://doi.org/10.2967/jnumed.117.190546

Background Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilises glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BA... Read More about Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans.

Efficacy of dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): a proof of principle double blinded randomized placebo controlled trial (2017)
Journal Article
Narkwichean, A., Maalouf, W. E., Baumgarten, M., Polanski, L., Raine-Fenning, N., Campbell, B. K., & Jayaprakasan, K. (2017). Efficacy of dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): a proof of principle double blinded randomized placebo controlled trial. European Journal of Obstetrics and Gynecology and Reproductive Biology, 218, https://doi.org/10.1016/j.ejogrb.2017.09.006

Objective: To evaluate the effect of DHEA supplementation on In-Vitro Fertilisation (IVF) outcome as assessed by ovarian response, oocyte developmental competence and live birth rates in women predicted to have poor ovarian reserve (OR). The feasibil... Read More about Efficacy of dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): a proof of principle double blinded randomized placebo controlled trial.

Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy (2017)
Journal Article
Obilade, O. A., Akanmu, A. S., Broughton Pipkin, F., & Afolabi, B. B. (2017). Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy. PLoS ONE, 12(9), Article e0184345. https://doi.org/10.1371/journal.pone.0184345

BACKGROUND: Pregnancy increases the risk of morbidity and mortality in sickle cell disease. We previously showed pregnant women with sickle cell disease to have a relatively low plasma renin concentration in late pregnancy, associated with a lack of... Read More about Prostacyclin, thromboxane and glomerular filtration rate are abnormal in sickle cell pregnancy.

Azithromycin for treatment of bronchiolitis obliterans syndrome in adult lung transplant recipients (2017)
Journal Article
Safavi, S., Prayle, A. P., Hall, I. P., & Parmar, J. (in press). Azithromycin for treatment of bronchiolitis obliterans syndrome in adult lung transplant recipients. Cochrane Database of Systematic Reviews, 2017(9), Article CD012782. https://doi.org/10.1002/14651858.CD012782

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: This review aims to look at the benefits and harms of azithromycin for the treatment of BOS in adult lung transplant recipients.

Weight gain during acute treatment of an initial pulmonary exacerbation is associated with a longer interval to the next exacerbation in adults with cystic fibrosis (2017)
Journal Article
Barr, H. L., Cámara, M., Barrett, D., Williams, P., Forrester, D., Smyth, A., …Fogarty, A. W. (in press). Weight gain during acute treatment of an initial pulmonary exacerbation is associated with a longer interval to the next exacerbation in adults with cystic fibrosis. ERJ Open Research, 3(3), https://doi.org/10.1183/23120541.00057-2017

High mobility group protein B1 is a predictor of poor survival in ovarian cancer (2017)
Journal Article
Machado, L. R., Moseley, P. M., Moss, R., Deen, S., Nolan, C. C., Spendlove, I., …Durrant, L. (2017). High mobility group protein B1 is a predictor of poor survival in ovarian cancer. Oncotarget, https://doi.org/10.18632/oncotarget.20538

High-mobility group protein B1 (HMGB1) has been implicated in numerous tumour types where expression regulates tumour cell growth and survival. We hypothesised that high HMGB1 expression in ovarian tumours would predict poor patient survival. Using... Read More about High mobility group protein B1 is a predictor of poor survival in ovarian cancer.