All Outputs (4387)

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis (2017)
Journal Article
Hobbs, B. D., de Jong, K., Lamontagne, M., Bossé, Y., Shrine, N., Artigas, M. S., …Cho, M. H. (in press). Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nature Genetics, 49(3), https://doi.org/10.1038/ng.3752

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 con... Read More about Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers (2017)
Journal Article
Heinink, T. P., Read, D. J., Mitchell, W. K., Bhalla, A., Lund, J. N., Phillips, B. E., & Williams, J. P. (2018). Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers. Clinical Physiology and Functional Imaging, 38(2), 213-219. https://doi.org/10.1111/cpf.12401

Background

Oesophageal Doppler monitoring (ODM) is used clinically to optimize cardiac output (CO) and guide fluid therapy. Despite limited experimental evidence, it is assumed that increasing CO increases visceral microvascular blood flow (MBF).... Read More about Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers.

‘Doing good by proxy’: Human-animal kinship and the ‘donation’ of canine blood (2017)
Journal Article
Ashall, V., & Hobson-West, P. (in press). ‘Doing good by proxy’: Human-animal kinship and the ‘donation’ of canine blood. Sociology of Health and Illness, 39(6), https://doi.org/10.1111/1467-9566.12534

This paper demonstrates the relevance of animals to medical sociology by arguing that pet owners’ accounts of veterinary decision-making can highlight key sociological themes which have important relevance to both human and animal health. Based on se... Read More about ‘Doing good by proxy’: Human-animal kinship and the ‘donation’ of canine blood.

Interpolated energy densities, correlation indicators and lower bounds from approximations to the strong coupling limit of DFT (2017)
Journal Article
Vuckovic, S., Irons, T. J., Wagner, L. O., Teale, A. M., & Gori-Giorgi, P. (2017). Interpolated energy densities, correlation indicators and lower bounds from approximations to the strong coupling limit of DFT. Physical Chemistry Chemical Physics, 19, https://doi.org/10.1039/C6CP08704C

We investigate the construction of approximated exchange-correlation functionals by interpolating locally along the adiabatic connection between the weak- and the strong-coupling regimes, focussing on the effect of using approximate functionals for t... Read More about Interpolated energy densities, correlation indicators and lower bounds from approximations to the strong coupling limit of DFT.

Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease (2017)
Journal Article
Batson, J., Toop, H. D., Redondo, C., Babaei-Jadidi, R., Chaikaud, A., Wearmouth, S. F., Gibbons, B., Allen, C., Tallant, C., Zhang, J., Du, C., Hancox, J. C., Hawtrey, T., Da Rocha, J., Griffith, R., Knapp, S., Bates, D. O., & Morris, J. C. (2017). Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease. ACS Chemical Biology, 12(3), 825-832. https://doi.org/10.1021/acschembio.6b01048

Serine/arginine-protein kinase 1 (SRPK1) regulates alternative splicing of VEGF-A to pro-angiogenic isoforms and SRPK1 inhibition can restore the balance of pro/antiangiogenic isoforms to normal physiological levels. The lack of potency and selectivi... Read More about Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease.

Synthesis and properties of a novel highly thermal stable N-propargyl monomer containing benzoxazole ring (2017)
Journal Article
Yang, G., Wang, C., Liu, C., Yang, Z., & Hou, X. (2018). Synthesis and properties of a novel highly thermal stable N-propargyl monomer containing benzoxazole ring. High Performance Polymers, 30(2), 239-246. https://doi.org/10.1177/0954008317690432

© 2017, © The Author(s) 2017. A novel highly thermal stable propargyl functional compound containing benzoxazole ring, N, N, N′, N′-tetra propargyl-5-amino-2-(p-aminophenyl) benzoxazole (TPAPB), was proposed and synthesized using a phase-transfer cat... Read More about Synthesis and properties of a novel highly thermal stable N-propargyl monomer containing benzoxazole ring.

Telling stories: engaging critical literacy through urban legends in an English secondary school (2017)
Journal Article
Jones, S., & Chapman, K. (in press). Telling stories: engaging critical literacy through urban legends in an English secondary school. English Teaching: Practice & Critique, 16(1), https://doi.org/10.1108/ETPC-02-2016-0031

Non-dominant voices have been further marginalised in the most recent National Curriculum in England (DfE 2014) and those working across the English teaching profession often find the subject framed according to narrow, assessment driven models and p... Read More about Telling stories: engaging critical literacy through urban legends in an English secondary school.

Ancillary academia: video shorts and the production of university paratexts (2017)
Journal Article
Grainge, P. (2017). Ancillary academia: video shorts and the production of university paratexts. Critical Studies in Media Communication, 34(2), 184-192. https://doi.org/10.1080/15295036.2017.1286024

This article considers the production of media paratexts beyond the bounds of the entertainment industry. Specifically, it examines the development of video content strategy by universities, and the paratextual function that video shorts serve in the... Read More about Ancillary academia: video shorts and the production of university paratexts.

The effective ingredients of social care support at home for people with dementia: a literature review (2017)
Journal Article
Argyle, E., Kelly, T., Gladman, J. R., & Jones, R. (2017). The effective ingredients of social care support at home for people with dementia: a literature review. Journal of Integrated Care, 25(2), 110-119. https://doi.org/10.1108/JICA-09-2016-0032

Purpose:
Formal ties between the theatre and research dissemination have only recently developed and its general efficacy is largely unknown. Here the purpose of this paper is to redress this neglect by examining the effectiveness of a research-base... Read More about The effective ingredients of social care support at home for people with dementia: a literature review.

Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study (2017)
Journal Article
Kuo, C. F., Grainge, M. J., Valdes, A. M., See, L. C., Yu, K. H., Steven Shaw, S. W., …Doherty, M. (2017). Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study. Rheumatology, 56(6), 928-933. https://doi.org/10.1093/rheumatology/kew500

© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. Objective. The aim was to estimate familial relative risk (RR) for RA and other autoimmune diseases and the genetic contri... Read More about Familial aggregation of rheumatoid arthritis and co-aggregation of autoimmune diseases in affected families: a nationwide population-based study.

Financial literacy, present bias and alternative mortgage products (2017)
Journal Article
Gathergood, J., & Weber, J. (2017). Financial literacy, present bias and alternative mortgage products. Journal of Banking and Finance, 78, 58-83. https://doi.org/10.1016/j.jbankfin.2017.01.022

Choosing a mortgage is one of the most important financial decisions made by a household. Financial innovation has given rise to more complex mortgage products with back-loaded payments, known as ‘Alternative Mortgage Products’ (AMPs), or ‘Interest-O... Read More about Financial literacy, present bias and alternative mortgage products.

Incentivising monitoring in open normative systems (2017)
Presentation / Conference Contribution
Alechina, N., Halpern, J. Y., Kash, I. A., & Logan, B. (2017). Incentivising monitoring in open normative systems.

We present an approach to incentivising monitoring for norm violations in open multi-agent systems such as Wikipedia. In such systems, there is no crisp definition of a norm violation; rather, it is a matter of judgement whether an agent’s behaviour... Read More about Incentivising monitoring in open normative systems.

Recurrent rearrangements of human amylase genes create multiple independent CNV series (2017)
Journal Article
Shwan, N. A., Louzada, S., Yang, F., & Armour, J. A. (2017). Recurrent rearrangements of human amylase genes create multiple independent CNV series. Human Mutation, 38(5), 532-539. https://doi.org/10.1002/humu.23182

The human amylase gene cluster includes the human salivary (AMY1) and pancreatic amylase genes (AMY2A and AMY2B), and is a highly variable and dynamic region of the genome. Copy number variation (CNV) of AMY1 has been implicated in human dietary adap... Read More about Recurrent rearrangements of human amylase genes create multiple independent CNV series.

Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma (2017)
Journal Article
Aravinthan, A. D., Bruni, S. G., Doyle, A. C., Thein, H.-H., Goldaracena, N., Issachar, A., Lilly, L. B., Selzner, N., Bhat, M., Sreeharsha, B., Selzner, M., Ghanekar, A., Cattral, M. S., McGilvray, I. D., Greig, P. D., Renner, E. L., Grant, D. R., & Sapisochin, G. (2017). Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma. Annals of Surgical Oncology, 24(7), https://doi.org/10.1245/s10434-017-5789-3

Background: Patients with hepatocellular carcinoma (HCC) beyond the traditional criteria (advanced HCC) are typically offered palliation, which is associated with a 3-year survival rate lower than 30%. This study aimed to describe the outcomes for a... Read More about Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma.

Microwave pyrolysis of biomass for bio-oil production: Scalable processing concepts (2017)
Journal Article
Beneroso, D., Monti, T., Kostas, E., & Robinson, J. (2017). Microwave pyrolysis of biomass for bio-oil production: Scalable processing concepts. Chemical Engineering Journal, 316, 481-498. https://doi.org/10.1016/j.cej.2017.01.130

The pursuit of sustainable hydrocarbon alternatives to fossil fuels has prompted an acceleration in the development of new technologies for biomass processing. Microwave pyrolysis of biomass has long been recognised to provide better quality bio-prod... Read More about Microwave pyrolysis of biomass for bio-oil production: Scalable processing concepts.

Commentary driver training: effects of commentary exposure, practice and production on hazard perception and eye movements (2017)
Journal Article
Young, A. H., Crundall, D., & Chapman, P. (2017). Commentary driver training: effects of commentary exposure, practice and production on hazard perception and eye movements. Accident Analysis and Prevention, 101, https://doi.org/10.1016/j.aap.2017.01.007

Commentary driving typically involves being trained in how to produce a verbal running commentary about what you can see, what you are doing, what might happen and what action you will take to avoid potential hazards, while driving. Although video-ba... Read More about Commentary driver training: effects of commentary exposure, practice and production on hazard perception and eye movements.

A new measuring method for friction factor by using ring with inner boss compression test (2017)
Journal Article
Hu, C., Yin, Q., Zhao, Z., & Ou, H. (2017). A new measuring method for friction factor by using ring with inner boss compression test. International Journal of Mechanical Sciences, 123, https://doi.org/10.1016/j.ijmecsci.2017.01.042

To overcome the disadvantage of the bulging effect due to non-uniform deformation in dimension measurement of the conventional ring compression test (RCT), a new measuring method for the friction factor called ring compression test with inner boss (R... Read More about A new measuring method for friction factor by using ring with inner boss compression test.

Moisture damage evaluation of aggregate–bitumen bonds with the respect of moisture absorption, tensile strength and failure surface (2017)
Journal Article
Zhang, J., Airey, G. D., Grenfell, J., & Apeagyei, A. K. (in press). Moisture damage evaluation of aggregate–bitumen bonds with the respect of moisture absorption, tensile strength and failure surface. Road Materials and Pavement Design, 18(4), https://doi.org/10.1080/14680629.2017.1286441

The moisture-induced deterioration of asphalt mixture is because of the loss of adhesion at the aggregate–bitumen interface and/or the loss of cohesion within the bitumen film. An experimental study was undertaken in this paper to characterise the ef... Read More about Moisture damage evaluation of aggregate–bitumen bonds with the respect of moisture absorption, tensile strength and failure surface.

Development, validity and reliability testing of the East Midlands Evaluation Tool (EMET) for measuring impacts on trainees’ confidence and competence following end of life care training (2017)
Journal Article
Whittaker, B., Parry, R., Bird, L., Watson, S., & Faull, C. (in press). Development, validity and reliability testing of the East Midlands Evaluation Tool (EMET) for measuring impacts on trainees’ confidence and competence following end of life care training. BMJ Supportive and Palliative Care, https://doi.org/10.1136/-2016001100

Objectives: To develop, test and validate a versatile questionnaire, the East Midlands Evaluation Tool (EMET), for measuring effects of end of life care training events on trainees’ self-reported confidence and competence.

Methods: A paper-based q... Read More about Development, validity and reliability testing of the East Midlands Evaluation Tool (EMET) for measuring impacts on trainees’ confidence and competence following end of life care training.

Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands (2017)
Journal Article
Mistry, P., Aied, A., Alexander, M. R., Shakesheff, K., Bennett, A., & Yang, J. (2017). Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands. Macromolecular Bioscience, 17(6), Article 1600472. https://doi.org/10.1002/mabi.201600472

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combinat... Read More about Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands.