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Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery (2017)
Journal Article
Varadhan, K. K., Constantin-Teodosiu, D., Constantin, D., Greenhaff, P. L., & Lobo, D. N. (2017). Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery. Clinical Nutrition, 37(6, Part A), 2178-2185. https://doi.org/10.1016/j.clnu.2017.10.020

Background & aims: Postoperative hyperglycaemia is common in patients having major surgery and is associated with adverse outcomes. This study aimed to determine whether bacteraemia contributed to postoperative systemic inflammation, and whether incr... Read More about Inflammation-mediated muscle metabolic dysregulation local and remote to the site of major abdominal surgery.

Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography (2017)
Journal Article
Harman, D. J., Ryder, S. D., James, M. W., Wilkes, E. A., Card, T. R., Aithal, G. P., & Guha, I. N. (2018). Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography. Alimentary Pharmacology and Therapeutics, 47(4), 504-515. https://doi.org/10.1111/apt.14463

Background: Rising cirrhosis incidence and mortality in the United Kingdom has been attributed predominantly to excess alcohol consumption. However, metabolic risk factors such as type 2 diabetes and obesity may also be important. Aim: To screen at-... Read More about Obesity and type 2 diabetes are important risk factors underlying previously undiagnosed cirrhosis in general practice: a cross-sectional study using Transient Elastography.

Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans (2017)
Journal Article
Alyami, J., Ladd, N., Pritchard, S. E., Hoad, C. L., Abdul Sultan, A., Spiller, R. C., …Taylor, M. A. (2017). Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans. Food Research International, https://doi.org/10.1016/j.foodres.2017.11.071

Cereal grain based porridges are commonly consumed throughout the world. Whilst some data are available for varieties that are popular in the Western world such as oats and rye, other ‘ancient’ grains used in the East and in Africa such as millets ar... Read More about Glycaemic, gastrointestinal and appetite responses to breakfast porridges from ancient cereal grains: a MRI pilot study in healthy humans.

Optimising the performance and interpretation of small bowel capsule endoscopy (2017)
Journal Article
Beg, S., Parra-Blanco, A., & Ragunath, K. (in press). Optimising the performance and interpretation of small bowel capsule endoscopy. Frontline Gastroenterology, https://doi.org/10.1136/flgastro-2017-100878

Small bowel capsule endoscopy has become a commonly used tool in the investigation of gastrointestinal symptoms and is now widely available in clinical practice. In contrast to conventional endoscopy, there is a lack of clear consensus on when compet... Read More about Optimising the performance and interpretation of small bowel capsule endoscopy.

Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1 (2017)
Journal Article
Mesalam, A. A., Desombere, I., Farhoudi, A., Van Houtte, F., Verhoye, L., Ball, J., …Meuleman, P. (2018). Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1. Virology, 514, https://doi.org/10.1016/j.virol.2017.10.019

Monoclonal antibodies (mAbs) targeting the hepatitis C virus (HCV) envelope have been raised mainly against envelope protein 2 (E2), while the antigenic epitopes of envelope protein 1 (E1) are not fully identified. Here we describe the detailed chara... Read More about Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1.

SOX9 predicts progression towards cirrhosis in patients while its loss protects against liver fibrosis (2017)
Journal Article
Athwal, V. S., Pritchett, J., Llewellyn, J., Martin, K., Camacho, E., Raza, S. M., …Hanley, K. P. (in press). SOX9 predicts progression towards cirrhosis in patients while its loss protects against liver fibrosis. EMBO Molecular Medicine, 9(12), https://doi.org/10.15252/emmm.201707860

Fibrosis and organ failure is a common endpoint for many chronic liver diseases. Much is known about the upstream inflammatory mechanisms provoking fibrosis and downstream potential for tissue remodeling. However, less is known about the transcriptio... Read More about SOX9 predicts progression towards cirrhosis in patients while its loss protects against liver fibrosis.

Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome (2017)
Journal Article
Vork, L., Keszthely, D., Mujagic, Z., Kruimel, J., Leue, C., Pontén, I., …Masclee, A. (in press). Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome. Neurogastroenterology and Motility, 30(3), Article e13244. https://doi.org/10.1111/nmo.13244

BACKGROUND: End-of-day questionnaires, which are considered the gold standard for assessing abdominal pain and other gastrointestinal (GI) symptoms in irritable bowel syndrome (IBS), are influenced by recall and ecological bias. The Experience Sampli... Read More about Development, content validity and cross-cultural adaptation of a Patient-Reported Outcome Measure for Real-time Symptom Assessment in Irritable Bowel Syndrome.

Surgical rates for Crohn’s Disease are decreasing: a population-based time trend analysis and validation study (2017)
Journal Article
Ma, C., Moran, G. W., Benchimol, E. I., Targownik, L. E., Heitman, S. J., Hubbard, J. N., …Kaplan, G. G. (2017). Surgical rates for Crohn’s Disease are decreasing: a population-based time trend analysis and validation study. American Journal of Gastroenterology, 112, https://doi.org/10.1038/ajg.2017.394

Objectives: Temporal changes for intestinal resections for Crohn’s disease (CD) are controversial. We validated administrative database codes for CD diagnosis and surgery in hospitalized patients and then evaluated temporal trends in CD surgical res... Read More about Surgical rates for Crohn’s Disease are decreasing: a population-based time trend analysis and validation study.

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo (2017)
Journal Article
Desombere, I., Mesalam, A. A., Urbanowicz, R. A., Van Houtte, F., Verhoye, L., Keck, Z., …Meuleman, P. (2017). A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo. Antiviral Research, 148, https://doi.org/10.1016/j.antiviral.2017.10.015

Infections with hepatitis C virus (HCV) represent a worldwide health burden and a prophylactic vaccine is still not available. Liver transplantation (LT) is often the only option for patients with HCV-induced end-stage liver disease. However, immedia... Read More about A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo.

Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time (2017)
Journal Article
Yu, A., Jackson, T., Tsume, Y., Koenigsknecht, M., Wysocki, J., Marciani, L., …Sun, D. (2017). Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time. AAPS Journal, 19(6), 1682-1690. https://doi.org/10.1208/s12248-017-0145-x

Gastrointestinal (GI) fluid volume and its dynamic change are integral to study drug disintegration, dissolution, transit, and absorption. However, key questions regarding the local volume and its absorption, secretion, and transit remain unanswered.... Read More about Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time.

The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature? (2017)
Journal Article
Corsetti, M., & Fox, M. (2017). The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?. F1000Research, 6, Article 1778. https://doi.org/10.12688/f1000research.12089.1

© 2017 Corsetti M and Fox M. Functional dyspepsia is a prevalent functional gastrointestinal disorder that can significantly erode the quality of life of sufferers and places a major cost burden on healthcare services. In this article, we review the... Read More about The management of functional dyspepsia in clinical practice: what lessons can be learnt from recent literature?.

Development of a telehealth monitoring service after colorectal surgery: a feasibility study (2017)
Journal Article
Bragg, D. D., Edis, H., Clark, S., Parsons, S. L., Perumpalath, B., Lobo, D. N., & Maxwell-Armstrong, C. A. (in press). Development of a telehealth monitoring service after colorectal surgery: a feasibility study. World Journal of Gastroenterology, 9(9), https://doi.org/10.4240/wjgs.v9.i9.193

AIM: To evaluate the feasibility of a text-messaging system to remotely monitor and support patients after discharge following elective colorectal surgery, within an enhanced recovery protocol. METHODS: Florence (FLO) is a National Health Service te... Read More about Development of a telehealth monitoring service after colorectal surgery: a feasibility study.

Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging (2017)
Journal Article
Perez-Cota, F., Smith, R. J., Moradi, E., Leija, A. L., Velickovic, K., Marques, L., …Clark, M. (2017). Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging

The mechanical properties of cells play an important role in cell function and behavior. This paper presents recent developments that have enabled the use of laser-generated phonons (ultrasound) with sub-optical wavelengths to look inside living cell... Read More about Cell imaging by phonon microscopy: sub-optical wavelength ultrasound for non-invasive imaging.

Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans (2017)
Journal Article
Law, J., Morris, D. E., Izzi Engbeaya, C., Salem, V., Coello, C., Robinson, L. J., …Symonds, M. E. (2018). Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans. Journal of Nuclear Medicine, 59(3), https://doi.org/10.2967/jnumed.117.190546

Background Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilises glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BA... Read More about Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans.

Association between infection with H. pylori and atopy in young Ethiopian children: a longitudinal study (2017)
Journal Article
Taye, B., Enquselassie, F., Tsegaye, A., Amberbir, A., Medhin, G., Fogarty, A. W., …Davey, G. (in press). Association between infection with H. pylori and atopy in young Ethiopian children: a longitudinal study. Clinical and Experimental Allergy, 47(10), https://doi.org/10.1111/cea.12995

Background: Epidemiological evidence from developed countries indicates that Helicobacter pylori infection correlates with a reduced risk of atopy and allergic disorders, however limited data are available from low-income countries. Objective: We... Read More about Association between infection with H. pylori and atopy in young Ethiopian children: a longitudinal study.

MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans (2017)
Journal Article
Khalaf, A., Hoad, C., Menys, A., Nowak, A., Taylor, S. A., Paparo, S., …Moran, G. W. (2018). MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans. Neurogastroenterology and Motility, 30(1), Article e13182. https://doi.org/10.1111/nmo.13182

Background: Feeding triggers inter-related gastrointestinal (GI) motor, peptide and appetite responses. These are rarely studied together due to methodological limitations. Recent MRI advances allow pan-intestinal, non-invasive assessment of motility... Read More about MRI assessment of the postprandial gastrointestinal motility and peptide response in healthy humans.

The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers (2017)
Journal Article
Kaewkangsadan, V., Verma, C., Eremin, J. M., Cowley, G. P., Ilyas, M., Satthaporn, S., & Eremin, O. (2017). The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers. Journal of Immunology Research, 2017, Article 1049023. https://doi.org/10.1155/2017/1049023

The tumour microenvironment consists of malignant cells, stroma, and immune cells. The role of adaptive immunity in inducing a pathological complete response (pCR) in breast cancer with neoadjuvant chemotherapy (NAC) is well studied. The contribution... Read More about The differential contribution of the innate immune system to a good pathological response in the breast and axillary lymph nodes induced by neoadjuvant chemotherapy in women with large and locally advanced breast cancers.

Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures (2017)
Journal Article
Kumar, D., Workman, V., O'Brien, M. C., McLaren, J. S., White, L. J., Ragunath, K., …Rose, F. R. (2017). Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures. Advanced Functional Materials, 27(38), Article 1702424. https://doi.org/10.1002/adfm.201702424

Endoscopic treatment of Barrett’s oesophagus often leads to further damage of healthy tissue causing fibrotic tissue formation termed as strictures. This study shows that synthetic, self-assembling peptide hydrogels (PeptiGelDesign) support the activ... Read More about Peptide hydrogels — a tissue engineering strategy for the prevention of oesophageal strictures.