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All Outputs (44)

Principles of bone and joint injuries and their healing (2017)
Journal Article
Nyary, T., & Scammell, B. E. (2018). Principles of bone and joint injuries and their healing. Surgery (Oxford), 36(1), https://doi.org/10.1016/j.mpsur.2017.10.005

This article describes the mechanisms of fracture healing (direct and indirect), general fracture management, the influence of the surgeon on the biology and biomechanical environment of bone healing, the management of articular fractures, and disord... Read More about Principles of bone and joint injuries and their healing.

Barriers and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence (2017)
Journal Article
Kanavaki, A. M., Rushton, A., Efstathiou, N., Alrushud, A., Klocke, R., Abhishek, A., & Duda, J. L. (2017). Barriers and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence. BMJ Open, 7(12), Article e017042. https://doi.org/10.1136/bmjopen-2017-017042

Physical activity (PA), including engagement in structured exercise, has a key role in the management of hip and knee osteoarthritis (OA). However, maintaining a physically active lifestyle is a challenge for people with OA. PA determinants in this p... Read More about Barriers and facilitators of physical activity in knee and hip osteoarthritis: a systematic review of qualitative evidence.

Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data (2017)
Journal Article
Sarmanova, A., Hall, M. C., Fernandes, G. S., Bhattacharya, A., Valdes, A. M., Walsh, D. A., …Zhang, W. (in press). Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data. Arthritis Research and Therapy, 19(281), https://doi.org/10.1186/s13075-017-1486-7

Background: Recently an important role for synovial pathology in the initiation and progression of knee osteoarthritis (OA) has been emphasised. This study aimed to examine whether ultrasonographydetected synovial changes (USSCs) associate with knee... Read More about Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data.

Long term outcomes of daily oral vs. pulsed intravenous cyclophosphamide in a non-trial setting in ANCA associated vasculitis (2017)
Journal Article
La-Crette, J., Royle, J., Lanyon, P. C., Ferraro, A., Butler, A., & Pearce, F. A. (2018). Long term outcomes of daily oral vs. pulsed intravenous cyclophosphamide in a non-trial setting in ANCA associated vasculitis. Clinical Rheumatology, 37(4), 1085–1090. https://doi.org/10.1007/s10067-017-3944-7

Objectives We aimed to compare risk of death, relapse, neutropenia and infection requiring hospital admission between unselected ANCA-associated vasculitis (AAV) patients according to whether cyclophosphamide induction was by daily oral (PO) or pulse... Read More about Long term outcomes of daily oral vs. pulsed intravenous cyclophosphamide in a non-trial setting in ANCA associated vasculitis.

Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery (2017)
Journal Article
Boitor, R., Kong, K., Shipp, D., Varma, S., Koloydenko, A., Kusum, K., …Ioan, N. (in press). Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery. Biomedical Optics Express, 8(12), https://doi.org/10.1364/BOE.8.005749

Multimodal spectral histopathology (MSH), an optical technique combining tissue auto-fluorescence (AF) imaging and Raman micro-spectroscopy (RMS), was previously proposed for detection of residual basal cell carcinoma (BCC) at the surface of surgical... Read More about Automated multimodal spectral histopathology for quantitative diagnosis of residual tumour during basal cell carcinoma surgery.

A systematic review of diagnostic criteria for psoriasis in adults and children: evidence from studies with a primary aim to develop or validate diagnostic criteria (2017)
Journal Article
Burden-Teh, E., Phillips, R., Thomas, K., Ratib, S., Grindlay, D., & Murphy, R. (2018). A systematic review of diagnostic criteria for psoriasis in adults and children: evidence from studies with a primary aim to develop or validate diagnostic criteria. British Journal of Dermatology, 178(5), 1035-1043. https://doi.org/10.1111/bjd.16104

Background: The diagnosis of psoriasis in adults and children is made clinically, for both patient management and the selection of participants in research. Diagnostic criteria provide a structure for clinical assessment, which in turn helps standard... Read More about A systematic review of diagnostic criteria for psoriasis in adults and children: evidence from studies with a primary aim to develop or validate diagnostic criteria.

Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared to men in the general population: a cross-sectional study (2017)
Journal Article
Fernandes, G. S., Parekh, S. M., Moses, J., Fuller, C., Scammell, B. E., Batt, M. E., …Doherty, M. (2017). Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared to men in the general population: a cross-sectional study. British Journal of Sports Medicine, https://doi.org/10.1136/bjsports-2017-097503

Objectives: To determine the prevalence of knee pain, radiographic knee osteoarthritis (RKOA), total knee replacement (TKR) and associated risk factors in male ex-professional footballers compared to men in the general population (comparison group).... Read More about Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared to men in the general population: a cross-sectional study.

A prospective, multicentre study of external ventricular drainage-related infections in the United Kingdom and Ireland (2017)
Journal Article
Jamjoom, A., Joannides, A., Poon, M., Chari, A., Zaben, M., Abdullah, M., …Ahmed, A. (2018). A prospective, multicentre study of external ventricular drainage-related infections in the United Kingdom and Ireland. Journal of Neurology, Neurosurgery and Psychiatry, 89, https://doi.org/10.1136/jnnp-2017-316415

Objectives External Ventricular Drain (EVD) insertion is a common neurosurgical procedure. EVD- related infection (ERI) is a major complication that can lead to morbidity and mortality. In this study, we aimed to establish a national ERI rate in t... Read More about A prospective, multicentre study of external ventricular drainage-related infections in the United Kingdom and Ireland.

Pain mechanisms in rheumatoid arthritis (2017)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2017). Pain mechanisms in rheumatoid arthritis. Clinical and Experimental Rheumatology, 35(S107), Article s94-s101

Understanding of the causes and underlying mechanisms of pain in people with RA is rapidly changing. With the advent of more effective disease modifying drugs, joint inflammation is becoming a more treatable cause of pain, and joint damage can often... Read More about Pain mechanisms in rheumatoid arthritis.

In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1-34 for the treatment of osteoporosis (2017)
Journal Article
Williams, A. J., Jordan, F., King, G., Lewis, A. L., Illum, L., Masud, T., …Pearson, R. G. (in press). In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1-34 for the treatment of osteoporosis. International Journal of Pharmaceutics, https://doi.org/10.1016/j.ijpharm.2017.10.029

Osteoporosis treatment with PTH 1-34 injections significantly reduces the incidence of bone fracture. Potential further reductions in fracture rate should be observed through nasal spray delivery to address the poor compliance associated with patient... Read More about In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1-34 for the treatment of osteoporosis.

Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study (2017)
Journal Article
Abhishek, A., Valdes, A. M., Jenkins, W., Zhang, W., & Doherty, M. (2017). Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study. PLoS ONE, 12(10), Article e0186096. https://doi.org/10.1371/journal.pone.0186096

Objectives To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute... Read More about Triggers of acute attacks of gout, does age of gout onset matter?: a primary care based cross-sectional study.

Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study (2017)
Journal Article
Pearce, F. A., Hubbard, R., Grainge, M. J., Watts, R. A., Abhishek, A., & Lanyon, P. C. (in press). Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study. QJM: An International Journal of Medicine, https://doi.org/10.1093/qjmed/hcx194

Background: People with granulomatosis with polyangiitis (GPA) commonly describe long delays before diagnosis. Aim: To study the natural history of GPA prior to diagnosis using primary care data, and determine whether clinical features could be iden... Read More about Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study.

The prevalence of psychological comorbidity in people with vitiligo: a systematic review and meta-analysis (2017)
Journal Article
Osinubi, O., Grainge, M. J., Ahmed, A., Batchelor, J. M., Grindlay, D., Thompson, A., & Ratib, S. (2018). The prevalence of psychological comorbidity in people with vitiligo: a systematic review and meta-analysis. British Journal of Dermatology, 178(4), 863-878. https://doi.org/10.1111/bjd.16049

Background: Vitiligo is a chronic disorder causing skin depigmentation with global prevalence varying from 0.2 to 1.8%. UK guidelines recommend assessment of psychological state during clinical evaluation of vitiligo. However, the prevalence of psych... Read More about The prevalence of psychological comorbidity in people with vitiligo: a systematic review and meta-analysis.

Sample size and number of outcome measures of veterinary randomised controlled trials of pharmaceutical interventions funded by different sources, a cross-sectional study (2017)
Journal Article
Wareham, K., Hyde, R., Grindlay, D. J., Brennan, M. L., & Dean, R. S. (2017). Sample size and number of outcome measures of veterinary randomised controlled trials of pharmaceutical interventions funded by different sources, a cross-sectional study. BMC Veterinary Research, 13, Article 295. https://doi.org/10.1186/s12917-017-1207-0

Background Randomised controlled trials (RCTs) are a key component of the veterinary evidence base. Sample sizes and defined outcome measures are crucial components of RCTs. To describe the sample size and number of outcome measures of veterinary... Read More about Sample size and number of outcome measures of veterinary randomised controlled trials of pharmaceutical interventions funded by different sources, a cross-sectional study.

Association between use of non–vitamin k oral anticoagulants with and without concurrent medications and risk of major bleeding in nonvalvular atrial fibrillation (2017)
Journal Article
Chang, S., Chou, I., Yeh, Y., Chiou, M., Wen, M., Kuo, C., …Kuo, C. (2017). Association between use of non–vitamin k oral anticoagulants with and without concurrent medications and risk of major bleeding in nonvalvular atrial fibrillation. Journal of the American Medical Association, 318(13), https://doi.org/10.1001/jama.2017.13883

Importance:  Non–vitamin K oral anticoagulants (NOACs) are commonly prescribed with other medications that share metabolic pathways that may increase major bleeding risk. Objective:  To assess the association between use of NOACs with and without... Read More about Association between use of non–vitamin k oral anticoagulants with and without concurrent medications and risk of major bleeding in nonvalvular atrial fibrillation.

Cast versus functional brace in the rehabilitation of patients treated non-operatively for a rupture of the Achilles tendon: protocol for the UK study of tendo achilles rehabilitation (UK STAR) multi-centre randomised trial (2017)
Journal Article
Achten, J., Parsons, N. R., Kearney, R. L., Maia Schlüssel, M., Liew, A. S., Dutton, S., …Costa, M. L. (2017). Cast versus functional brace in the rehabilitation of patients treated non-operatively for a rupture of the Achilles tendon: protocol for the UK study of tendo achilles rehabilitation (UK STAR) multi-centre randomised trial. BMJ Open, 7(10), Article e019628. https://doi.org/10.1136/bmjopen-2017-019628

INTRODUCTION Achilles tendon rupture affects over 11 000 people yearly in the UK, and the incidence is increasing. Controversy remains with regard to the best rehabilitation strategy for these patients. In operatively treated patients, functional... Read More about Cast versus functional brace in the rehabilitation of patients treated non-operatively for a rupture of the Achilles tendon: protocol for the UK study of tendo achilles rehabilitation (UK STAR) multi-centre randomised trial.

Confusion and abdominal symptoms following a rugby tackle (2017)
Journal Article
Ioannides, D., Davies, M., & Kluzek, S. (2017). Confusion and abdominal symptoms following a rugby tackle. BMJ Case Reports, 2017, Article bcr-2017-222160. https://doi.org/10.1136/bcr-2017-222160

A 19-year-old man was sent to the emergency department following a pitch-side assessment for suspected concussion, unexplained upper abdominal tenderness and vomiting, following a high-impact tackle during a rugby match. A Focussed Assessment with So... Read More about Confusion and abdominal symptoms following a rugby tackle.

Knee pain and related health in the community study (KPIC): a cohort study protocol (2017)
Journal Article
Fernandes, G. S., Sarmanova, A., Warner, S. C., Harvey, H., Akin-Akinyosoye, K., Richardson, H., …Doherty, M. (in press). Knee pain and related health in the community study (KPIC): a cohort study protocol. BMC Musculoskeletal Disorders, 18(404), https://doi.org/10.1186/s12891-017-1761-4

Background: The incidence, progression and related risk factors for recent-onset knee pain (KP) remain uncertain. This study aims to examine the natural history of KP including incidence and progression and to identify possible phenotypes and their a... Read More about Knee pain and related health in the community study (KPIC): a cohort study protocol.