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Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group (2017)
Journal Article
Perego, P., Hempel, G., Linder, S., Bradshaw, T. D., Larsen, A. K., Peters, G. J., & Phillips, R. M. (in press). Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group. Cancer Chemotherapy and Pharmacology, https://doi.org/10.1007/s00280-017-3502-7

An increasing number of manuscripts focus on the in vitro evaluation of established and novel anti-tumour agents in experimental models. Whilst the design of such in vitro assays is inherently flexible, some of these studies lack the minimum informat... Read More about Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group.

Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis (2017)
Journal Article
Kay, A. G., Long, G., Tyler, G., Stefan, A., Broadfoot, S. J., Piccinini, A. M., …Kehoe, O. (2017). Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis. Scientific Reports, 7, Article 18019. https://doi.org/10.1038/s41598-017-18144-w

We evaluated the therapeutic potential of mesenchymal stem cell-conditioned medium (CM-MSC) as an alternative to cell therapy in an antigen-induced model of arthritis (AIA). Disease severity and cartilage loss were evaluated by histopathological anal... Read More about Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis.

Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding (2017)
Journal Article
Purdie, L., Alexander, C., Spain, S. G., & Magnusson, J. P. (2018). Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding. Molecular Pharmaceutics, 15(2), https://doi.org/10.1021/acs.molpharmaceut.7b00805

DNA-based drug delivery vehicles have displayed promise for the delivery of intercalating drugs. Here, we demonstrate that oligonucleotides modified with an alkyl chain can bind to human serum albumin, mimicking the natural binding of fatty acids. Th... Read More about Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding.

An augmented delivery of the anticancer agent, curcumin, to the colon (2017)
Journal Article
Sabra, R., Billa, N., & Roberts, C. J. (2018). An augmented delivery of the anticancer agent, curcumin, to the colon. Reactive and Functional Polymers, 123, https://doi.org/10.1016/j.reactfunctpolym.2017.12.012

This work describes the formulation aspects of an orally viable curcumin-containing mucoadhesive nanoparticulate system for management of colon cancer. Curcumin is documented to possess anticancer properties whilst modified citrus pectin yields a gal... Read More about An augmented delivery of the anticancer agent, curcumin, to the colon.

The Endocannabinoid, Anandamide, Induces Cannabinoid Receptor-Independent Cell Death in Renal Proximal Tubule Cells (2017)
Journal Article
Schlosser, M., Löser, H., Siegmund, S. V., Montesinos-Rongen, M., Bindila, L., Lutz, B., …Fries, J. W. (2017). The Endocannabinoid, Anandamide, Induces Cannabinoid Receptor-Independent Cell Death in Renal Proximal Tubule Cells. CellBio, 6(4), 35-55. https://doi.org/10.4236/cellbio.2017.64004

Background: The endocannabinoid (EC) system is well characterized in the central nervous system but scarcely studied in peripheral organs. In this paper, we newly identify the effect of the EC anandamide (AEA) upon renal proximal tubule cells. Meth... Read More about The Endocannabinoid, Anandamide, Induces Cannabinoid Receptor-Independent Cell Death in Renal Proximal Tubule Cells.

Enhancing cell and gene therapy manufacture through the application of advanced fluorescent optical sensors (Review) (2017)
Journal Article
Harrison, R. P., & Chauhan, V. M. (2018). Enhancing cell and gene therapy manufacture through the application of advanced fluorescent optical sensors (Review). Biointerphases, 13(1), Article 01A301-1-01A301-8. https://doi.org/10.1116/1.5013335

Cell and gene therapies (CGTs) are examples of future therapeutics that can be used to cure or alleviate the symptoms of disease, by repairing damaged tissue or reprogramming defective genetic information. However, despite the recent advancements in... Read More about Enhancing cell and gene therapy manufacture through the application of advanced fluorescent optical sensors (Review).

A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells (2017)
Journal Article
Arruda, M. A., Stoddart, L. A., Gherbi, K., Briddon, S. J., Kellam, B., & Hill, S. J. (in press). A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells. Frontiers in Pharmacology, 8(908), https://doi.org/10.3389/fphar.2017.00908

Recent advances in fluorescent ligand technology have enabled the study of G protein-coupled receptors in their native environment without the need for genetic modification such as addition of N-terminal fluorescent or bioluminescent tags. Here, we h... Read More about A non-imaging high throughput approach to chemical library screening at the unmodified adenosine-A3 receptor in living cells.

Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography (2017)
Journal Article
Yang, J., Shakesheff, K. M., & Prasopthum, A. (2018). Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography. Biofabrication, 10(2), Article 025002. https://doi.org/10.1088/1758-5090/aaa15b

Three-dimensional (3D) printing is a powerful manufacturing tool for making 3D structures with well-defined architectures for a wide range of applications. The field of tissue engineering has also adopted this technology to fabricate scaffolds for ti... Read More about Direct three-dimensional printing of polymeric scaffolds with nanofibrous topography.

Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells (2017)
Journal Article
Vining, K. H., Scherba, J. C., Bever, A., Alexander, M. R., Celiz, A. D., & Mooney, D. J. (2018). Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells. Advanced Materials, 30(4), Article 1704486. https://doi.org/10.1002/adma.201704486

Dental disease annually affects billions of patients, and while regenerative dentistry aims to heal dental tissue after injury, existing polymeric restorative materials, or fillings, do not directly participate in the healing process in a bioinstruct... Read More about Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells.

The physicochemical fingerprint of Necator americanus (2017)
Journal Article
Chauhan, V. M., Scurr, D. J., Christie, T., Telford, G., Aylott, J. W., & Pritchard, D. (in press). The physicochemical fingerprint of Necator americanus. PLoS Neglected Tropical Diseases, 11(12), Article e0005971. https://doi.org/10.1371/journal.pntd.0005971

Necator americanus, a haematophagous hookworm parasite, infects ~10% of the world’s population and is considered to be a significant public health risk. Its lifecycle has distinct stages, permitting its successful transit from the skin via the lungs... Read More about The physicochemical fingerprint of Necator americanus.

Screening natural libraries of human milk oligosaccharides against lectins using CaR-ESI-MS (2017)
Journal Article
El-Hawiet, A., Chen, Y., Shams-Ud-Doha, K., Kitova, E. N., Kitov, P. I., Bode, L., …Klassen, J. S. (2018). Screening natural libraries of human milk oligosaccharides against lectins using CaR-ESI-MS. Analyst, 143(2), 536-548. https://doi.org/10.1039/c7an01397c

© 2018 The Royal Society of Chemistry. Human milk oligosaccharides (HMOs) afford many health benefits to breast-fed infants, such as protection against infection and regulation of the immune system, through the formation of non-covalent interactions... Read More about Screening natural libraries of human milk oligosaccharides against lectins using CaR-ESI-MS.

Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers (2017)
Journal Article
Zuliani-Alvarez, L., Marzeda, A. M., Deligne, C., Schwenzer, A., McCann, F. E., Marsden, B. D., …Midwood, K. S. (2017). Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers. Nature Communications, 8(1), Article 1595. https://doi.org/10.1038/s41467-017-01718-7

© 2017 The Author(s). Pattern recognition underpins innate immunity; the accurate identification of danger, including infection, injury, or tumor, is key to an appropriately targeted immune response. Pathogen detection is increasingly well defined me... Read More about Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.

An integrated dyspepsia module for first year Pharmacy students: a flexible and generic template for integrating science with clinical and professional practice (2017)
Journal Article
De Matteis, C. I., Randall, M. D., Harvey, E. J., Morris, A., Winkler, G. S., & Boardman, H. F. (2019). An integrated dyspepsia module for first year Pharmacy students: a flexible and generic template for integrating science with clinical and professional practice. American Journal of Pharmaceutical Education, 83(1), Article 6508. https://doi.org/10.5688/ajpe6508

Objective: To design an integrated dyspepsia module for first year pharmacy undergraduates, which combines clinical and professional practice with fundamental sciences, in five different science subject areas, as a prototype for future disease- or sy... Read More about An integrated dyspepsia module for first year Pharmacy students: a flexible and generic template for integrating science with clinical and professional practice.

The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power (2017)
Journal Article
Passarelli, M. K., Pirkl, A., Moellers, R., Grinfeld, D., Kollmer, F., Havelund, R., …Gilmore, I. S. (2017). The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power. Nature Methods, 14(12), 1175-1183. https://doi.org/10.1038/nmeth.4504

© 2017 Nature America, Inc., part of Springer Nature. All rights reserved. We report the development of a 3D OrbiSIMS instrument for label-free biomedical imaging. It combines the high spatial resolution of secondary ion mass spectrometry (SIMS; unde... Read More about The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power.

Interventions for the reduction of prescribed opioid use in chronic non-cancer pain (2017)
Journal Article
Eccleston, C., Fisher, E., Thomas, K. H., Hearn, L., Derry, S., Stannard, C., …Moore, R. A. (in press). Interventions for the reduction of prescribed opioid use in chronic non-cancer pain. Cochrane Database of Systematic Reviews, 11, Article CD010323. https://doi.org/10.1002/14651858.CD010323.pub3

Background This is the first update of the original Cochrane Review published in 2013. The conclusions of this review have not changed from the 2013 publication. People with chronic non-cancer pain who are prescribed and are taking opioids can hav... Read More about Interventions for the reduction of prescribed opioid use in chronic non-cancer pain.

Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS (2017)
Journal Article
Newman, C. F., Havelund, R., Passarelli, M. K., Marshall, P. S., Francis, I., West, A., …Dollery, C. T. (2017). Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS. Analytical Chemistry, 89(22), 11944-11953. https://doi.org/10.1021/acs.analchem.7b01436

ToF-SIMS is a label-free imaging method that has been shown to enable imaging of amiodarone in single rat macrophage (NR8383) cells. In this study, we show that the method extends to three other cell lines relevant to drug discovery: human embryonic... Read More about Intracellular drug uptake: a comparison of single cell measurements using ToF-SIMS imaging and quantification from cell populations with LC/MS/MS.

Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II) (2017)
Journal Article
Wang, J., Wang, C., Wu, Z., Li, X., Xu, S., Liu, J., …Xu, J. (2018). Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II). Chemical Biology and Drug Design, 91(3), 756-762. https://doi.org/10.1111/cbdd.13136

A series of novel 4-isochromanone compounds bearing N-benzyl pyridinium moiety were designed and synthesized as acetylcholinesterase (AChE) inhibitors. The biological evaluation showed that most of the target compounds exhibited potent inhibitory act... Read More about Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II).

Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation (2017)
Journal Article
Zgair, A., Lee, J. B., Wong, J. C. M., Taha, D. A., Aram, J., Virgilio, D. D., …Gershkovich, P. (2017). Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation. Scientific Reports, 7, 1-12. https://doi.org/10.1038/s41598-017-15026-z

Cannabidiol (CBD) and ?9-tetrahydrocannabinol (THC) have well documented immunomodulatory effects in vitro, but not following oral administration in humans. Here we show that oral co-administration of cannabinoids with lipids can substantially increa... Read More about Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation.

Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development (2017)
Journal Article
H-T. Kwok, C., Devonshire, I. M., Imraish, A., Greenspon, C. M., Lockwood, S., Fielden, C., …Hathway, G. J. (2017). Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development. PAIN, 158(11), 2222-2232. https://doi.org/10.1097/j.pain.0000000000001027

Significant age and experience-dependent remodelling of spinal and supraspinal neural networks occur resulting in altered pain responses in early life. In adults endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which mod... Read More about Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development.

Osteogenic programming of human mesenchymal stem cells with highly efficient intracellular delivery of RUNX2 (2017)
Journal Article
Thiagarajan, L., Abu-Awwad, H. A. M., & Dixon, J. E. (2017). Osteogenic programming of human mesenchymal stem cells with highly efficient intracellular delivery of RUNX2. Stem Cells Translational Medicine, 6(12), https://doi.org/10.1002/sctm.17-0137

Mesenchymal stem cells (MSCs) are being exploited in regenerative medicine due to their tri-lineage differentiation and immunomodulation activity. Currently, there are two major challenges when directing the differentiation of MSCs for therapeutic ap... Read More about Osteogenic programming of human mesenchymal stem cells with highly efficient intracellular delivery of RUNX2.