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All Outputs (3)

UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery (2017)
Journal Article
Abbas, Z. S., Latif, M. L., Dovlatova, N., Fox, S. C., Heptinstall, S., Dunn, W. R., & Ralevic, V. (2018). UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery. Vascular Pharmacology, 103-105, https://doi.org/10.1016/j.vph.2017.12.063

Aims UDP-sugars can act as extracellular signalling molecules, but relatively little is known about their cardiovascular actions. The P2Y14 receptor is a Gi/o-coupled receptor which is activated by UDP-glucose and related sugar nucleotides. In thi... Read More about UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery.

A critical role for cystathionine-?-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery (2017)
Journal Article
Donovan, J., Wong, P., Roberts, R. E., Garle, M., Alexander, S. P., Dunn, W. R., & Ralevic, V. (2017). A critical role for cystathionine-?-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery. Vascular Pharmacology, 93-95, https://doi.org/10.1016/j.vph.2017.05.004

Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow under ischemic conditions, however its mechanism is not fully elucidated. Hydrogen sulfide (H2S) is reported to be an oxygen sensor/transducer in the vasculatu... Read More about A critical role for cystathionine-?-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery.

Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilation and leptin release (2017)
Journal Article
Baker, H. A., Dunn, W. R., Daly, C., & Ralevic, V. (2017). Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilation and leptin release. Cardiovascular Research, 113(8), 962-972. https://doi.org/10.1093/cvr/cvx062

Aims: Electrical field stimulation (EFS) elicits robust sensory neurogenic relaxation responses in the rat isolated mesenteric arterial bed but these responses are absent or difficult to demonstrate in isolated arteries. We believe that this mismatch... Read More about Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilation and leptin release.