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Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation (2017)
Journal Article
Pepper, K., Masson, T., De Focatiis, D. S., & Howdle, S. M. (in press). Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation. Journal of Supercritical Fluids, 133(1), https://doi.org/10.1016/j.supflu.2017.10.014

High temperature melts or use of organic solvents are not practicable approaches for encapsulating protein based or thermally labile drugs into degradable polymers. Here, we demonstrate that poly(ethylene glycol) (PEG) in combination with supercritic... Read More about Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation.

Versatile routes to functional RAFT chain transfer agents through the Passerini multicomponent reaction (2017)
Journal Article
Pearce, A. K., Travanut, A., Couturaud, B., Taresco, V., Howdle, S. M., Alexander, M. R., & Alexander, C. (2017). Versatile routes to functional RAFT chain transfer agents through the Passerini multicomponent reaction. ACS Macro Letters, 6(7), 781-785. https://doi.org/10.1021/acsmacrolett.7b00415

The widespread adoption of RAFT polymerization stems partly from the ease and utility of installing a functional chain transfer agent onto the ends of the generated polymer chains. In parallel, the Passerini multicomponent reaction offers great versa... Read More about Versatile routes to functional RAFT chain transfer agents through the Passerini multicomponent reaction.

One-pot synthesis of micron-sized polybetaine particles: innovative use of supercritical carbon dioxide (2017)
Journal Article
Bassett, S. P., Birkin, N. A., Jennings, J., Champman, E., O'Reilly, R. K., Howdle, S. M., & Willcock, H. (in press). One-pot synthesis of micron-sized polybetaine particles: innovative use of supercritical carbon dioxide. Polymer Chemistry, 8, https://doi.org/10.1039/C7PY00455A

Polybetaines exhibit unique properties combining anti-polyelectrolyte and low protein fouling behaviour, as well as biocompatibility. To date, the synthesis of polybetaine particles >50 nm has proved to be extremely challenging with standard emulsion... Read More about One-pot synthesis of micron-sized polybetaine particles: innovative use of supercritical carbon dioxide.

Mild synthesis of poly(HEMA)-networks as well-defined nanoparticles in supercritical carbon dioxide (2017)
Journal Article
Parilti, R., Alaimo, D., Grignard, B., Boury, F., Howdle, S., & Jerome, C. (2017). Mild synthesis of poly(HEMA)-networks as well-defined nanoparticles in supercritical carbon dioxide. Journal of Materials Chemistry B, 5, https://doi.org/10.1039/C7TB00740J

Free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate was carried out in supercritical carbon dioxide (scCO2) in the presence of stabilisers based on polyethylene oxide (PEO) and poly(heptadecafluorodecyl acrylate) (PFDA). Different a... Read More about Mild synthesis of poly(HEMA)-networks as well-defined nanoparticles in supercritical carbon dioxide.

Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells (2017)
Journal Article
Gulfam, M., Matini, T., Monteiro, P. F., Riva, R., Collins, H., Spriggs, K., …Alexander, C. (2017). Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells. Biomaterials Science, 5, https://doi.org/10.1039/c6bm00888g

Polymer micelles have emerged as promising carriers for controlled release applications, however, several limitations of micelle-based drug delivery have also been reported. To address these issues, we have synthesized a functional biodegradable and... Read More about Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells.

Synthesis of polymeric microcapsules by interfacial-suspension cationic photopolymerisation of divinyl ether monomer in aqueous suspension (2017)
Journal Article
Benedetti, M., Congdon, T. R., Bassett, S. P., Alauhdin, M., Howdle, S. M., Haddleton, D. M., …Schiller, T. L. (2017). Synthesis of polymeric microcapsules by interfacial-suspension cationic photopolymerisation of divinyl ether monomer in aqueous suspension. Polymer Chemistry, 8(6), 972-975. https://doi.org/10.1039/c6py01782g

© 2017 The Royal Society of Chemistry. Polymeric microcapusles have been synthesised with a markedly more hydrophillic monomer than previously reported, triethylene glycol divinyl ether, using cationic photopolymerisation in an aqueous environment. C... Read More about Synthesis of polymeric microcapsules by interfacial-suspension cationic photopolymerisation of divinyl ether monomer in aqueous suspension.