All Outputs (4)

Molecular adaptations of adipose tissue to 6 weeks of morning fasting vs. daily breakfast consumption in lean and obese adults (2017)
Journal Article
Gonzalez, J. T., Richardson, J. D., Chowdhury, E. A., Koumanov, F., Holman, G. D., Cooper, S., …Betts, J. A. (2018). Molecular adaptations of adipose tissue to 6 weeks of morning fasting vs. daily breakfast consumption in lean and obese adults. Journal of Physiology, 596(4), https://doi.org/10.1113/JP275113

This study assessed molecular responses of human subcutaneous abdominal adipose tissue (SCAT) to 6 weeks of morning fasting. Forty‐nine healthy lean (n = 29) and obese (n = 20) adults provided SCAT biopsies before and after 6 weeks of morning fasting... Read More about Molecular adaptations of adipose tissue to 6 weeks of morning fasting vs. daily breakfast consumption in lean and obese adults.

Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice (2017)
Journal Article
Lewis, J. E., Samms, R. J., Cooper, S., Luckett, J. C., Perkins, A. C., Dunbar, J. D., …Tsintzas, K. (2017). Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice. Endocrinology, 158(10), 3090–3096. https://doi.org/10.1210/en.2017-00591

The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population. Antibody-mediated targeting of fibroblast growt... Read More about Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice.

Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster (2017)
Journal Article
Lewis, J. E., Samms, R. J., Cooper, S., Luckett, J. C., Perkins, A. C., Adams, A. C., …Ebling, F. J. (in press). Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster. Scientific Reports, 7(1), Article 4238. https://doi.org/10.1038/s41598-017-03607-x

FGF21 exerts profound metabolic effects in Siberian hamsters exposed to long day (LD) photoperiods that increase appetite and adiposity, however these effects are attenuated in short day (SD) animals that display hypophagia and reduced adiposity. The... Read More about Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster.

Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men (2017)
Journal Article
Tsintzas, K., Stephens, F. B., Snijders, T., Wall, B. T., Cooper, S., Mallinson, J., …van Loon, L. J. (2017). Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men. Experimental Gerontology, 93, https://doi.org/10.1016/j.exger.2017.03.018

The aim of this study was to examine the temporal relationship between intramyocellular lipid (IMCL) content and the expression of genes associated with IMCL turnover, fat metabolism, and inflammation during recovery from an acute bout of resistance... Read More about Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men.