All Outputs (4)

Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma (2017)
Journal Article
Matthey, M., Roberts, R., Seidinger, A., Simon, A., Schröder, R., Kuschak, M., …Wenzel, D. (in press). Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma. Science Translational Medicine, 9(407), https://doi.org/10.1126/scitranslmed.aag2288

Obstructive lung diseases are common causes of disability and death worldwide. A hallmark feature is aberrant activation of Gq protein–dependent signaling cascades. Currently, drugs targeting single G protein (heterotrimeric guanine nucleotide–bindin... Read More about Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma.

Sex differences in the role of phospholipase A2-dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs (2017)
Journal Article
Ahmad, A. A., Randall, M. D., & Roberts, R. E. (2017). Sex differences in the role of phospholipase A2-dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs. Journal of Physiology, 595(21), https://doi.org/10.1113/JP274831

Previous studies have demonstrated that perivascular adipose tissue (PVAT) causes vasoconstriction. In this present study, we determined the role of cyclooxygenase-derived prostanoids in this contractile response and determined whether there were any... Read More about Sex differences in the role of phospholipase A2-dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs.

Sex differences in the regulation of porcine coronary artery tone by perivascular adipose tissue: a role of adiponectin? (2017)
Journal Article
Ahmad, A., Randall, M. D., & Roberts, R. E. (in press). Sex differences in the regulation of porcine coronary artery tone by perivascular adipose tissue: a role of adiponectin?. British Journal of Pharmacology, 174(16), https://doi.org/10.1111/bph.13902

Background and Purpose- As there is sexual dimorphism in the regulation of vascular tone, the aim of this present study was to determine whether there are sex differences in perivascular adipose tissue (PVAT) - mediated regulation of the porcine coro... Read More about Sex differences in the regulation of porcine coronary artery tone by perivascular adipose tissue: a role of adiponectin?.

A critical role for cystathionine-?-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery (2017)
Journal Article
Donovan, J., Wong, P., Roberts, R. E., Garle, M., Alexander, S. P., Dunn, W. R., & Ralevic, V. (2017). A critical role for cystathionine-?-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery. Vascular Pharmacology, 93-95, https://doi.org/10.1016/j.vph.2017.05.004

Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow under ischemic conditions, however its mechanism is not fully elucidated. Hydrogen sulfide (H2S) is reported to be an oxygen sensor/transducer in the vasculatu... Read More about A critical role for cystathionine-?-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery.