All Outputs (5)

Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease (2017)
Journal Article
Shindi, R., Al-Mehairi, A., Negm, O. H., Kalsheker, N., Gale, N., Shale, D. J., …Fairclough, L. C. (2017). Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease. Clinical Immunology, 183, https://doi.org/10.1016/j.clim.2017.09.020

Autoimmunity occurs in chronic obstructive pulmonary disease (COPD). We describe an antigen microarray for detecting serum autoantibodies (AAbs) to determine how IgM, as well as IgG, AAbs distinguish patients with COPD from controls with a history of... Read More about Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease.

A signalome screening approach in the autoinflammatory disease TNF receptor associated periodic syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing (2017)
Journal Article
Figueredo, G., Todd, I., Negm, O. H., Reps, J., Radford, P., Figueredo, G. P., …Tighe, P. J. (2017). A signalome screening approach in the autoinflammatory disease TNF receptor associated periodic syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing. Pharmacological Research, 125, 188-200. https://doi.org/10.1016/j.phrs.2017.08.012

© 2017 Elsevier Ltd TNF receptor associated periodic syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1). Current therapies for TRAPS are limited and do not target the pro-inflammatory signalling pathways tha... Read More about A signalome screening approach in the autoinflammatory disease TNF receptor associated periodic syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing.

High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection (2017)
Journal Article
Monaghan, T. M., Negm, O. H., MacKenzie, B., Hamed, M. R., Shone, C. C., Humphreys, D., …Wilcox, M. H. (2017). High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection. Clinical and Experimental Gastroenterology, 10, https://doi.org/10.2147/CEG.S133939

Objectives: Despite multiple risk factors and a high rate of colonization for Clostridium difficile, the occurrence of C. difficile infection in patients with cystic fibrosis is rare. The aim of this study was to compare the prevalence of binding C.... Read More about High prevalence of subclass-specific binding and neutralizing antibodies against Clostridium difficile toxins in adult cystic fibrosis sera: possible mode of immunoprotection against symptomatic C. difficile infection.

Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration (2017)
Journal Article
Negm, O. H., MacKenzie, B., Hamed, M., Ahmad, O., Shone, C. C., Humphreys, D., …Monaghan, T. M. (2017). Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration. Clinical and Experimental Immunology, 188(3), 437-443. https://doi.org/10.1111/cei.12946

The prevalence of serum antibodies against Clostridium difficile (CD) toxins A and B in healthy populations have prompted interest in evaluating the therapeutic activity of intravenous immunoglobulin (IVIg) in individuals experiencing severe or recur... Read More about Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration.

The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs (2017)
Journal Article
Salazar, F., Awuah, D., Negm, O. H., Shakib, F., & Ghaemmaghami, A. M. (2017). The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs. Scientific Reports, 7(1), Article 43337. https://doi.org/10.1038/srep43337

A controlled inflammatory response is required for protection against infection, but persistent inflammation causes tissue damage. Dendritic cells (DCs) have a unique capacity to promote both inflammatory and anti-inflammatory processes. One key mech... Read More about The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs.