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All Outputs (5)

N-term 2017: Proteostasis via the N-terminus (2017)
Journal Article
Dissmeyer, N., Graciet, E., Holdsworth, M. J., & Gibbs, D. J. (in press). N-term 2017: Proteostasis via the N-terminus. Trends in Biochemical Sciences, https://doi.org/10.1016/j.tibs.2017.11.006

N-term 2017 was the first international meeting to bring together researchers from diverse disciplines with a shared interest in protein N-terminal modifications and the N-end rule pathway of ubiquitin-mediated proteolysis, providing a platform for i... Read More about N-term 2017: Proteostasis via the N-terminus.

N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway (2017)
Journal Article
Zhang, H., Gannon, L., Hassall, K. L., Deery, M. J., Gibbs, D. J., Holdsworth, M. J., …Theodoulou, F. L. (in press). N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway. New Phytologist, https://doi.org/10.1111/nph.14909

The N-end rule pathway of targeted protein degradation is an important regulator of diverse processes in plants but detailed knowledge regarding its influence on the proteome is lacking. To investigate the impact of the Arg/N-end rule pathway on the... Read More about N-terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N-end rule pathway.

The Cys-Arg/N-end rule pathway is a general sensor of abiotic stress in flowering plants (2017)
Journal Article
Vicente, J., Mendiondo, G. M., Movahedi, M., Peirats-Llobet, M., Juan, Y., Shen, Y., …Holdsworth, M. J. (2017). The Cys-Arg/N-end rule pathway is a general sensor of abiotic stress in flowering plants. Current Biology, 27(20), Article 3183-3190.e4. https://doi.org/10.1016/j.cub.2017.09.006

Abiotic stresses impact negatively on plant growth, profoundly affecting yield and quality of crops. Although much is known about plant responses, very little is understood at the molecular level about the initial sensing of environmental stress. In... Read More about The Cys-Arg/N-end rule pathway is a general sensor of abiotic stress in flowering plants.

First hints of new sensors (2017)
Journal Article
Holdsworth, M. J. (in press). First hints of new sensors. Nature Plants, 3, https://doi.org/10.1038/s41477-017-0031-7

A mechanism by which plants detect and respond to oxygen starvation has been known for some years. Three recent papers suggest that we haven’t been seeing the full picture.

Community recommendations on terminology and procedures used in flooding and low oxygen stress research (2017)
Journal Article
Sasidharan, R., Bailey-Serres, J., Ashikari, M., Atwell, B. J., Colmer, T. D., Fagerstedt, K., …Voesenek, L. A. C. J. (2017). Community recommendations on terminology and procedures used in flooding and low oxygen stress research. New Phytologist, 214(4), 1403-1407. https://doi.org/10.1111/nph.14519

Apart from playing a key role in important biochemical reactions, molecular oxygen (O2) and its by-products also have crucial signaling roles in shaping plant developmental programs and environmental responses. Even under normal conditions, sharp O2... Read More about Community recommendations on terminology and procedures used in flooding and low oxygen stress research.