All Outputs (3)

Drug delivery in a tumour cord model: a computational simulation (2017)
Journal Article
Hubbard, M. E., Jove, M., Loadman, P., Phillips, R., Twelves, C., & Smye, S. (2017). Drug delivery in a tumour cord model: a computational simulation. Royal Society Open Science, 4, https://doi.org/10.1098/rsos.170014

The tumour vasculature and microenvironment is complex and heterogeneous, contributing to reduced delivery of cancer drugs to the tumour. We have developed an in silico model of drug transport in a tumour cord to explore the effect of different drug... Read More about Drug delivery in a tumour cord model: a computational simulation.

Bayesian calibration, validation and uncertainty quantification for predictive modelling of tumour growth: a tutorial (2017)
Journal Article
Collis, J., Connor, A. J., Paczkowski, M., Kannan, P., Pitt-Francis, J., Byrne, H. M., & Hubbard, M. E. (2017). Bayesian calibration, validation and uncertainty quantification for predictive modelling of tumour growth: a tutorial. Bulletin of Mathematical Biology, 79(4), 939-974. https://doi.org/10.1007/s11538-017-0258-5

In this work we present a pedagogical tumour growth example, in which we apply calibration and validation techniques to an uncertain, Gompertzian model of tumour spheroid growth. The key contribution of this article is the discussion and application... Read More about Bayesian calibration, validation and uncertainty quantification for predictive modelling of tumour growth: a tutorial.

Effective equations governing an active poroelastic medium (2017)
Journal Article
Collis, J., Brown, D., Hubbard, M. E., & O'Dea, R. D. (2017). Effective equations governing an active poroelastic medium. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 473(2198), https://doi.org/10.1098/rspa.2016.0755

In this work we consider the spatial homogenization of a coupled transport and fluid-structure interaction model, to the end of deriving a system of effective equations describing the flow, elastic deformation, and transport in an active poroelastic... Read More about Effective equations governing an active poroelastic medium.