All Outputs (2)

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons (2017)
Journal Article
Scholz, N., Guan, C., Nieberler, M., Grotemeyer, A., Maiellaro, I., Gao, S., …Kittel, R. J. (2017). Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. eLife, 6, Article e28360. https://doi.org/10.7554/elife.28360

Adhesion-type G protein-coupled receptors (aGPCRs), a large molecule family with over 30 members in humans, operate in organ development, brain function and govern immunological responses. Correspondingly, this receptor family is linked to a multitud... Read More about Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons.

Experimental and mathematical analysis of cAMP nanodomains (2017)
Journal Article
Lohse, C., Bock, A., Maiellaro, I., Hannawacker, A., Schad, L. R., Lohse, M. J., & Bauer, W. R. (2017). Experimental and mathematical analysis of cAMP nanodomains. PLoS ONE, 12(4), Article e0174856. https://doi.org/10.1371/journal.pone.0174856

In their role as second messengers, cyclic nucleotides such as cAMP have a variety of intracellular effects. These complex tasks demand a highly organized orchestration of spatially and temporally confined cAMP action which should be best achieved by... Read More about Experimental and mathematical analysis of cAMP nanodomains.