All Outputs (8)

Exercise-induced ‘browning’ of adipose tissues (2017)
Journal Article
Aldiss, P., Betts, J. A., Sale, C., Pope, M., Budge, H., & Symonds, M. E. (2018). Exercise-induced ‘browning’ of adipose tissues. Metabolism, 81, https://doi.org/10.1016/j.metabol.2017.11.009

Global rates of obesity continue to rise and are necessarily the consequence of a long-term imbalance between energy intake and energy expenditure. This is the result of an expansion of adipose tissue due to both the hypertrophy of existing adipocyte... Read More about Exercise-induced ‘browning’ of adipose tissues.

Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans (2017)
Journal Article
Law, J., Morris, D. E., Izzi Engbeaya, C., Salem, V., Coello, C., Robinson, L. J., …Symonds, M. E. (2018). Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans. Journal of Nuclear Medicine, 59(3), https://doi.org/10.2967/jnumed.117.190546

Background Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilises glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BA... Read More about Thermal imaging is a non-invasive alternative to PET-CT for measurement of brown adipose tissue activity in humans.

Tissue cell stress response to obesity and its interaction with late gestational diet (2017)
Journal Article
Saroha, V., Dellschaft, N. S., Keisler, D. H., Gardner, D. S., Budge, H., Sebert, S. P., & Symonds, M. E. (2018). Tissue cell stress response to obesity and its interaction with late gestational diet. Reproduction, Fertility and Development, 30, https://doi.org/10.1071/RD16494

Intra-uterine growth restriction in late pregnancy can contribute to adverse long term metabolic health in the offspring. We utilised an animal (sheep) model of maternal dietary manipulation in late pregnancy, combined with exposure of the offspring... Read More about Tissue cell stress response to obesity and its interaction with late gestational diet.

Beyond obesity - thermogenic adipocytes and cardiometabolic health (2017)
Journal Article
Aldiss, P., Dellschaft, N. S., Sacks, H., Budge, H., & Symonds, M. E. (in press). Beyond obesity - thermogenic adipocytes and cardiometabolic health. Hormone Molecular Biology and Clinical Investigation, 31(2), https://doi.org/10.1515/hmbci-2017-0007

The global prevalence of obesity and related cardiometabolic disease continues to increase through the 21st century. Whilst multi-factorial, obesity is ultimately caused by chronic caloric excess. However, despite numerous interventions focussing on... Read More about Beyond obesity - thermogenic adipocytes and cardiometabolic health.

Newborn infants with bilious vomiting: a national audit of neonatal transport services (2017)
Journal Article
Ojha, S., Sand, L., Ratnavel, N., Kempley, S., Sinha, A., Mohinuddin, S., …Leslie, A. (2017). Newborn infants with bilious vomiting: a national audit of neonatal transport services. Archives of Disease in Childhood, 102(6), Article F515-518. https://doi.org/10.1136/archdischild-2016-312208

Objective: The precautionary approach to urgently investigate infants with bilious vomiting has increased the numbers referred to transport teams and tertiary surgical centres. The aim of this national UK audit was to quantify referrals, determine th... Read More about Newborn infants with bilious vomiting: a national audit of neonatal transport services.

Ontogeny and thermogenic role for sternal fat in female sheep (2017)
Journal Article
Henry, B. A., Pope, M., Birtwistle, M., Loughnan, R., Alagal, R., Fuller-Jackson, J., …Symonds, M. E. (in press). Ontogeny and thermogenic role for sternal fat in female sheep. Endocrinology, 158(7), https://doi.org/10.1210/en.2017-00081

Brown adipose tissue acting through a unique uncoupling protein (UCP1) has a critical role in preventing hypothermia in new-born sheep but is then considered to rapidly disappear during postnatal life. The extent to which the anatomical location of f... Read More about Ontogeny and thermogenic role for sternal fat in female sheep.

The placenta, maternal diet and adipose tissue development in the newborn (2017)
Journal Article
Symonds, M. E., Bloor, I., Ojha, S., & Budge, H. (2017). The placenta, maternal diet and adipose tissue development in the newborn. Annals of Nutrition and Metabolism, 70(3), 232-235. https://doi.org/10.1159/000464301

Background: A majority of adipose tissue present in the newborn possess the unique mitochondrial protein, uncoupling protein (UCP1). It is thus highly metabolically active and capable of producing 300 times more heat per unit mass than any other orga... Read More about The placenta, maternal diet and adipose tissue development in the newborn.

Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo (2017)
Journal Article
Scotney, H., Symonds, M. E., Law, J., Budge, H., Sharkey, D., & Manolopoulos, K. N. (2017). Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo. Metabolism, 70, 125-132. https://doi.org/10.1016/j.metabol.2017.01.024

© 2017 The Authors Introduction Brown adipose tissue (BAT) is a thermogenic organ with substantial metabolic capacity and has important roles in the maintenance of body weight and metabolism. Regulation of BAT is primarily mediated through the β-adre... Read More about Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo.