Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor

Weitsman, Gregory; Mitchell, Nicholas J.; Evans, Rachel; Cheung, Anthony; Kalber, Tammy L.; Bofinger, Robin; Fruhwirth, Gilbert O.; Keppler, Melanie; Wright, Zoe V. F.; Barber, Paul R.; Gordon, Peter; Koning, Tamra de; Wulaningsih, Wahyu; Sander, Kerstin; Vojnovic, Borivoj; Hailes, Helen C.; Tabor, Alethea B.; Ng, Tony

doi:10.1038/onc.2016.522

All Outputs (3)

Laws in ecology: diverse modes of explanation for a holistic science? (2017)
Journal Article
Gunton, R., & Gilbert, F. (2017). Laws in ecology: diverse modes of explanation for a holistic science?. Zygon, 52(2), 538-560. https://doi.org/10.1111/zygo.12334

Ecology’s reputation as a holistic and soft science is partly due to widespread misconceptions of its nature as well as shortcomings in its methodology. We show how the pursuit of empirical laws of ecology can foster the emergence of a more unified a... Read More about Laws in ecology: diverse modes of explanation for a holistic science?.

A pilot study to survey the carnivore community in the hyper-arid environment of South Sinai Mountains (2017)
Journal Article
Gecchele, L. V., Bremner-Harrison, S., Gilbert, F., Soultan, A. E., Davison, A., & Durrant, K. L. (2017). A pilot study to survey the carnivore community in the hyper-arid environment of South Sinai Mountains. Journal of Arid Environments, 141, https://doi.org/10.1016/j.jaridenv.2017.01.009

Carnivores are one of the taxa most affected by habitat fragmentation and human persecution; as a result, most carnivore species are declining; for this reason monitoring changes in carnivore population is paramount to plan effective conservation pro... Read More about A pilot study to survey the carnivore community in the hyper-arid environment of South Sinai Mountains.

Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor (2017)
Journal Article
Weitsman, G., Mitchell, N. J., Evans, R., Cheung, A., Kalber, T. L., Bofinger, R., …Ng, T. (in press). Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor. Oncogene, https://doi.org/10.1038/onc.2016.522

Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested clinically, the success rate for these agents in the clinic is low, particularly in terms of the im... Read More about Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor.