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Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions (2017)
Journal Article
Chou, I., Lim, S., Tanasescu, R., Al-Radaideh, A., Mougin, O. E., Tench, C. R., …Constantinescu, C. S. (in press). Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions. Journal of Neuroimaging, https://doi.org/10.1111/jon.12474

BACKGROUND AND PURPOSE: Fluid-attenuated inversion recovery (FLAIR) imaging at 3 Tesla (T) field strength is the most sensitive modality for detecting white matter lesions in multiple sclerosis. While 7T FLAIR is effective in detecting cortical lesio... Read More about Seven-Tesla magnetization transfer imaging to detect multiple sclerosis white matter lesions.

Automated segmentation of retinal layers from optical coherence tomography images using geodesic distance (2017)
Journal Article
Duan, J., Tench, C., Gottlob, I., Proudlock, F., & Bai, L. (2017). Automated segmentation of retinal layers from optical coherence tomography images using geodesic distance. Pattern Recognition, 72, 158-175. https://doi.org/10.1016/j.patcog.2017.07.004

Optical coherence tomography (OCT) is a noninvasive imaging technique that can produce images of the eye at the microscopic level. OCT image segmentation to detect retinal layer boundaries is a fundamental procedure for diagnosing and monitoring the... Read More about Automated segmentation of retinal layers from optical coherence tomography images using geodesic distance.

Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome (2017)
Journal Article
Reckziegel, D., Bailey, H., Cottam, W. J., Tench, C. R., Mahajan, R. P., Walsh, D. A., …Auer, D. P. (in press). Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome. BMJ Open, 7(6), Article e014013. https://doi.org/10.1136/bmjopen-2016-014013

Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current la... Read More about Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome.

Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study (2017)
Journal Article
Tanasescu, R., Constantinescu, C. S., Tench, C. R., & Manouchehrinia, A. (2018). Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study. Nicotine and Tobacco Research, 20(5), 589-595. https://doi.org/10.1093/ntr/ntx084

Background: Smoking is associated with a more severe disease course in people with multiple sclerosis (MS). The magnitude of effect of smoking cessation on MS progression is unknown. The aim of this study was to quantify the impact of smoking cessati... Read More about Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study.

Coordinate based random effect size meta-analysis of neuroimaging studies (2017)
Journal Article
Tench, C. R., Tanasescu, R., Constantinescu, C. S., Auer, D. P., & Cottam, W. J. (in press). Coordinate based random effect size meta-analysis of neuroimaging studies. NeuroImage, 153, https://doi.org/10.1016/j.neuroimage.2017.04.002

Low power in neuroimaging studies can make them difficult to interpret, and Coordinate based meta-analysis (CBMA) may go some way to mitigating this issue. CBMA has been used in many analyses to detect where published functional MRI or voxel-based mo... Read More about Coordinate based random effect size meta-analysis of neuroimaging studies.

The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis (2017)
Journal Article
Morandi, E., Tanasescu, R., Tarlinton, R. E., Constantinescu, C. S., Zhang, W., Tench, C. R., & Gran, B. (2017). The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis. PLoS ONE, 12(2), Article e0172415. https://doi.org/10.1371/journal.pone.0172415

Background: The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.... Read More about The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis.