The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis

Boehm, Cordula M.; Obado, Samson; Gadelha, Catarina; Kaupisch, Alexandra; Manna, Paul T.; Gould, Gwyn W.; Munson, Mary; Chait, Brian T.; Rout, Michael P.; Field, Mark C.

doi:10.1371/journal.ppat.1006063

All Outputs (3)

Technical challenges of working with extracellular vesicles (2017)
Journal Article
Ramirez, M. I., Amorim, M. G., Gadelha, C., Milic, I., Welsh, J. A., Freitas, V. M., …Dias-Neto, E. (2018). Technical challenges of working with extracellular vesicles. Nanoscale, 10(3), 881-906. https://doi.org/10.1039/c7nr08360b

© 2018 The Royal Society of Chemistry. Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions. These nanosi... Read More about Technical challenges of working with extracellular vesicles.

Lineage-specific proteins essential for endocytosis in trypanosomes (2017)
Journal Article
Manna, P. T., Obado, S. O., Boehm, C., Gadelha, C., Sali, A., Chait, B. T., …Field, M. C. (2017). Lineage-specific proteins essential for endocytosis in trypanosomes. Journal of Cell Science, 130, 1379-1392. https://doi.org/10.1242/jcs.191478

Clathrin-mediated endocytosis (CME) is the most evolutionarily ancient endocytic mechanism known, and in many lineages the sole mechanism for internalisation. Significantly, in mammalian cells CME is responsible for the vast bulk of endocytic flux an... Read More about Lineage-specific proteins essential for endocytosis in trypanosomes.

The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis (2017)
Journal Article
Boehm, C. M., Obado, S., Gadelha, C., Kaupisch, A., Manna, P. T., Gould, G. W., …Field, M. C. (2017). The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis. PLoS Pathogens, 13(1), 1-25. https://doi.org/10.1371/journal.ppat.1006063

© 2017 Boehm et al. Membrane transport is an essential component of pathogenesis for most infectious organisms. In African trypanosomes, transport to and from the plasma membrane is closely coupled to immune evasion and antigenic variation. In mammal... Read More about The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis.