All Outputs (103)

Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers (2016)
Journal Article
England, R. M., Hare, J. I., Barnes, J., Wilson, J., Smith, A., Strittmatter, N., …Ashford, M. B. (2017). Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers. Journal of Controlled Release, 247, https://doi.org/10.1016/j.jconrel.2016.12.034

Irinotecan is used clinically for the treatment of colorectal cancer; however, its utility is limited by its narrow therapeutic index. We describe the use of a generation 5 l-lysine dendrimer that has been part-modified with a polyoxazoline as a drug... Read More about Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers.

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults (2016)
Journal Article
Wiffen, P. J., Knaggs, R., Derry, S., Cole, P., Phillips, T., & Moore, R. A. (2016). Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults. Cochrane Database of Systematic Reviews, Article CD012227. https://doi.org/10.1002/14651858.CD012227.pub2

BACKGROUND Paracetamol, either alone or in combination with codeine or dihydrocodeine, is commonly used to treat chronic neuropathic pain. This review sought evidence for efficacy and harm from randomised double-blind studies. OBJECTIVES To... Read More about Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults.

The structural modification of natural products for novel drug discovery (2016)
Journal Article
Yao, H., Liu, J., Xu, S., Zhu, Z., & Xu, J. (in press). The structural modification of natural products for novel drug discovery. Expert Opinion on Drug Discovery, 12(2), https://doi.org/10.1080/17460441.2016.1272757

Introduction: Throughout history, natural products (NPs) have provided a rich source of compounds that have wide applications in the fields of medicine, health sciences, pharmacy and biology. Although naturally active substances are good lead compoun... Read More about The structural modification of natural products for novel drug discovery.

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile (2016)
Journal Article
van Eijk, E., Paschalis, V., Green, M., Friggen, A. H., Larson, M. A., Spriggs, K., …Smits, W. K. (2016). Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile. Open Biology, 6(12), Article 160272. https://doi.org/10.1098/rsob.160272

DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of D... Read More about Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile.

5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus (2016)
Journal Article
Zapotoczna, M., Murray, E. J., Hogan, S., O'Gara, J. P., Chhabra, S. R., Chan, W. C., …Williams, P. (2017). 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 72(3), 744-753. https://doi.org/10.1093/jac/dkw482

Objectives: Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential of 5-hydroxyethyl-3-tetradec... Read More about 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus.

Views on unwanted effects of leave-on emollients and experiences surrounding their incidence (2016)
Journal Article
Oakley, R., & Lawton, S. (2016). Views on unwanted effects of leave-on emollients and experiences surrounding their incidence. Dermatological Nursing, 15(4),

Background: The mainstay treatment for eczema is leave-on emollients. The aim of this study was to find out more about unwanted effects that have been reported with their use, as little is known due to a lack of formal reporting. Aims: To gain a g... Read More about Views on unwanted effects of leave-on emollients and experiences surrounding their incidence.

The impact of detergents on the tissue decellularization process: a ToF-SIMS study (2016)
Journal Article
White, L. J., Taylor, A. J., Faulk, D. M., Keane, T. J., Saldin, L. T., Reing, J. E., …Badylak, S. F. (2017). The impact of detergents on the tissue decellularization process: a ToF-SIMS study. Acta Biomaterialia, 50, https://doi.org/10.1016/j.actbio.2016.12.033

Biologic scaffolds are derived from mammalian tissues, which must be decellularized to remove cellular antigens that would otherwise incite an adverse immune response. Although widely used clinically, the optimum balance between cell removal and the... Read More about The impact of detergents on the tissue decellularization process: a ToF-SIMS study.

Do statin users adhere to a healthy diet and lifestyle?: the Australian Diabetes, Obesity and Lifestyle Study (2016)
Journal Article
Johal, S., Jamsen, K. M., Bell, S. J., McNamara, K. P., Magliano, D., Liew, D., …Ilomäki, J. (in press). Do statin users adhere to a healthy diet and lifestyle?: the Australian Diabetes, Obesity and Lifestyle Study. European Journal of Preventive Cardiology, https://doi.org/10.1177/2047487316684054

Background Lifestyle and dietary advice typically precedes or accompanies the prescription of statin medications. However, evidence for adherence to this advice is sparse. The objective was to compare saturated fat intake, exercise, alcohol consum... Read More about Do statin users adhere to a healthy diet and lifestyle?: the Australian Diabetes, Obesity and Lifestyle Study.

Chemical intervention in plant sugar signalling increases yield and resilience (2016)
Journal Article
Griffiths, C. A., Sagar, R., Geng, Y., Primavesi, L. F., Patel, M. K., Passarelli, M. K., …Davis, B. G. (2016). Chemical intervention in plant sugar signalling increases yield and resilience. Nature, 540(7634), 574-578. https://doi.org/10.1038/nature20591

The pressing global issue of food insecurity due to population growth, diminishing land and variable climate can only be addressed in agriculture by improving both maximum crop yield potential and resilience. Genetic modification is one potential sol... Read More about Chemical intervention in plant sugar signalling increases yield and resilience.

Intercultural capability: exploring first year HE students' reflections on and experiences of their higher education experience (2016)
Conference Proceeding
Mullen, E., Eccles, S., Dippold, D., & Bridges, S. (2016). Intercultural capability: exploring first year HE students' reflections on and experiences of their higher education experience.

This round table discussion presents the initial stages of a cross-institution project exploring the reflections and expectations of first year international and home students. This study aims to capture students' early experiences in higher educatio... Read More about Intercultural capability: exploring first year HE students' reflections on and experiences of their higher education experience.

Integrating academic, professional and personal learning through multicultural group work (2016)
Presentation / Conference
Bridges, S. (2016, December). Integrating academic, professional and personal learning through multicultural group work. Paper presented at Exploring freedom and control in global higher education: SHRE Annual Research Conference, Newport, South Wales

Multicultural group work is an element of pedagogy which presents rich opportunities for helping students function more effectively within the intercultural contexts of their worlds. Drawing on theories of cosmopolitanism and the ‘capability approac... Read More about Integrating academic, professional and personal learning through multicultural group work.

Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry (2016)
Journal Article
Amekyeh, H., Billa, N., & Roberts, C. J. (2017). Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry. International Journal of Pharmaceutics, 517(1-2), https://doi.org/10.1016/j.ijpharm.2016.12.001

Oral delivery of pharmaceuticals requires that they retain their physical and chemical attributes during transit within the gastrointestinal (GI) tract, for the manifestation of desired therapeutic profiles. Solid lipid nanoparticles (SLNs) are used... Read More about Correlating gastric emptying of amphotericin B and paracetamol solid lipid nanoparticles with changes in particle surface chemistry.

Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes (2016)
Journal Article
Rawson, F. J., Cole, M., Aylott, J. W., Milne, W., Collins, C., Jackson, S. K., …Hicks, J. (in press). Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes. Scientific Reports, 6(37672), https://doi.org/10.1038/srep37672

With the rapidly increasing demands for ultrasensitive biodetection, the design and applications of new nano-scale materials for development of sensors based on optical and electrochemical transducers have attracted substantial interest. In particula... Read More about Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes.

Phosphonium polymers for gene delivery (2016)
Journal Article
Loczenski Rose, V., Mastrotto, F., & Mantovani, G. (in press). Phosphonium polymers for gene delivery. Polymer Chemistry, 8, https://doi.org/10.1039/C6PY01855F

Phosphonium salt-containing polymers have very recently started to emerge as attractive materials for the engineering non-viral gene delivery systems. Compared to more frequently utilised ammonium-based polymers, some of these materials can enhance b... Read More about Phosphonium polymers for gene delivery.

Supporting underserved patients with their medicines: a study protocol for a patient/professional coproduced education intervention for community pharmacy staff to improve the provision and delivery of Medicine Use Reviews (MURs) (2016)
Journal Article
Latif, A., Pollock, K., Anderson, C., Waring, J., Solomon, J., Chen, L., …Wharrad, H. (2016). Supporting underserved patients with their medicines: a study protocol for a patient/professional coproduced education intervention for community pharmacy staff to improve the provision and delivery of Medicine Use Reviews (MURs). BMJ Open, 6(12), Article e013500. https://doi.org/10.1136/bmjopen-2016-013500

Introduction Community pharmacy increasingly features in global strategies to modernise the delivery of primary healthcare. Medicine Use Reviews (MURs) form part of the English Government's medicines management strategy to improve adherence and r... Read More about Supporting underserved patients with their medicines: a study protocol for a patient/professional coproduced education intervention for community pharmacy staff to improve the provision and delivery of Medicine Use Reviews (MURs).

Extracellular matrix hydrogels from decellularized tissues: structure and function (2016)
Journal Article
Saldin, L. T., Cramer, M. C., Velankar, S. S., White, L. J., & Badylak, S. F. (2017). Extracellular matrix hydrogels from decellularized tissues: structure and function. Acta Biomaterialia, 49, https://doi.org/10.1016/j.actbio.2016.11.068

Extracellular matrix (ECM) bioscaffolds prepared from decellularized tissues have been used to facilitate constructive and functional tissue remodeling in a variety of clinical applications. The discovery that these ECM materials could be solubilized... Read More about Extracellular matrix hydrogels from decellularized tissues: structure and function.

Annexin A2 antibodies but not inhibitors of the annexin A2 heterotetramer impair productive HIV-1 infection of macrophages in vitro (2016)
Journal Article
Woodham, A. W., Sanna, A. M., Taylor, J. R., Skeate, J. G., Da Silva, D. M., Dekker, L. V., & Kast, W. M. (2016). Annexin A2 antibodies but not inhibitors of the annexin A2 heterotetramer impair productive HIV-1 infection of macrophages in vitro. Virology Journal, 13(1), 1-5. https://doi.org/10.1186/s12985-016-0649-5

© 2016 The Author(s). During sexual transmission of human immunodeficiency virus (HIV), macrophages are initial targets for HIV infection. Secretory leukocyte protease inhibitor (SLPI) has been shown to protect against HIV infection of macrophages th... Read More about Annexin A2 antibodies but not inhibitors of the annexin A2 heterotetramer impair productive HIV-1 infection of macrophages in vitro.

Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma (2016)
Journal Article
Lee, J. B., Zgair, A., Kim, T. H., Kim, M. G., Yoo, S. D., Fischer, P. M., & Gershkovich, P. (2017). Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma. Journal of Chromatography B, 1040, 73-80. https://doi.org/10.1016/j.jchromb.2016.11.024

Bexarotene is currently marketed for treatment of cutaneous T-cell lymphoma and there has been growing interest in its therapeutic effectiveness for other cancers. Neuroprotective effects of bexarotene have also been reported. In this study, a simple... Read More about Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma.

Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain (2016)
Journal Article
Huang, J., Burston, J. J., Li, L., Ashraf, S., Mapp, P. I., Bennett, A. J., …Chapman, V. (2017). Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain. Arthritis and Rheumatology, 69(5), 996-1008. https://doi.org/10.1002/art.40001

Objective: Pain is a major symptom of osteoarthritis (OA); current analgesics either do not offer adequate pain relief or are associated with serious side effects. Herein we have investigated the therapeutic potential of targeting the resolvin recept... Read More about Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain.

New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications (2016)
Journal Article
Taresco, V., Suksiriworapong, J., Styliari, I. D., Argent, R. H., Swainson, S. M., Booth, J., …Garnett, M. C. (in press). New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications. RSC Advances, 6(111), 109401-109405. https://doi.org/10.1039/C6RA21464A

A novel class of biodegradable polyesters has been generated by coupling poly(glycerol adipate) with N-acyl aromatic amino acids. This new set of polymers from this highly versatile polymeric platform may offer unprecedented new opportunities to prod... Read More about New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications.