All Outputs (174)

Distal junctional kyphosis in patients with Scheuermann’s disease: a retrospective radiographic analysis (2016)
Journal Article
Ghasemi, A., Stubig, T., Nasto, L. A., Ahmed, M., & Mehdian, H. (in press). Distal junctional kyphosis in patients with Scheuermann’s disease: a retrospective radiographic analysis. European Spine Journal, https://doi.org/10.1007/s00586-016-4924-3

Purpose To investigate the relationship between preoperative and postoperative spinopelvic alignment and occurrence of DJK/DJF. Study design/setting This was a retrospective observational cohort study. Patient sample The sample include... Read More about Distal junctional kyphosis in patients with Scheuermann’s disease: a retrospective radiographic analysis.

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease (2016)
Journal Article
Thomas, K. S., Batchelor, J. M., Bath-Hextall, F., Chalmers, J., Clarke, T., Crowe, S., …Williams, H. C. (2016). A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease. Programme Grants for Applied Research, 4(18), https://doi.org/10.3310/pgfar04180

Background Skin diseases are very common and can have a large impact on the quality of life of patients and caregivers. This programme addressed four diseases: (1) eczema, (2) vitiligo, (3) squamous cell skin cancer (SCC) and (4) pyoderma gangreno... Read More about A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease.

Cognitive rehabilitation for memory deficits after stroke (2016)
Journal Article
das Nair, R., Cogger, H., Worthington, E., & Lincoln, N. (2017). Cognitive rehabilitation for memory deficits after stroke. Stroke, 48(2), Article e28-e29. https://doi.org/10.1161/STROKEAHA.116.015377

Memory problems are common after a stroke, leading to difficulties in everyday life. Memory rehabilitation aims to help retrain lost functions or to teach patients strategies to compensate for them. Although some studies have reported positive outcom... Read More about Cognitive rehabilitation for memory deficits after stroke.

Potential pitfalls when denoising resting state fMRI data using nuisance regression (2016)
Journal Article
Bright, M. G., Tench, C. R., & Murphy, K. (2017). Potential pitfalls when denoising resting state fMRI data using nuisance regression. NeuroImage, 154, 159-168. https://doi.org/10.1016/j.neuroimage.2016.12.027

In resting state fMRI, it is necessary to remove signal variance associated with noise sources, leaving cleaned fMRI time-series that more accurately reflect the underlying intrinsic brain fluctuations of interest. This is commonly achieved through n... Read More about Potential pitfalls when denoising resting state fMRI data using nuisance regression.

Cardiovascular events and all-cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs: a Bayesian meta-analysis of survival data (2016)
Journal Article
Bain, S., Druyts, E., Balijepalli, C., Baxter, C. A., Currie, C. J., Das, R., …Mills, E. J. (2017). Cardiovascular events and all-cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs: a Bayesian meta-analysis of survival data. Diabetes, Obesity and Metabolism, 19(3), 329-335. https://doi.org/10.1111/dom.12821

Aim: To conduct a systematic review and meta-analysis to determine the risk of cardiovascular events and all-cause mortality associated with sulphonylureas (SUs) vs other glucose lowering drugs in patients with T2DM (T2DM. Materials and methods: A s... Read More about Cardiovascular events and all-cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs: a Bayesian meta-analysis of survival data.

Is clarithromycin a potential treatment for cachexia in people with lung cancer?: a feasibility study (2016)
Journal Article
Awan, S., Crosby, V., Potter, V., Hennig, I., Baldwin, D., Ndlovu, M., …Wilcock, A. (2017). Is clarithromycin a potential treatment for cachexia in people with lung cancer?: a feasibility study. Lung Cancer, 104, https://doi.org/10.1016/j.lungcan.2016.12.010

Clarithromycin may improve cachexia and survival in non-small cell lung cancer (NSCLC), but adequately controlled data are lacking. This study was undertaken primarily to inform the feasibility and scale of a phase III trial. Eligible consenting pati... Read More about Is clarithromycin a potential treatment for cachexia in people with lung cancer?: a feasibility study.

A comparison of humanoid and non-humanoid robots in supporting the learning of pupils with severe intellectual disabilities (2016)
Conference Proceeding
Aslam, S., Standen, P., Shopland, N., & Burton, A. (2016). A comparison of humanoid and non-humanoid robots in supporting the learning of pupils with severe intellectual disabilities. In Proceedings - 2016 International Conference on Interactive Technologies and Games (ITAG). https://doi.org/10.1109/iTAG.2016.9

Previous research has shown that the humanoid NAO robot can enhance learning as well as improve communication in children with intellectual disabilities. However, most special needs schools cannot afford the humanoid NAO robot due to high costs. Coul... Read More about A comparison of humanoid and non-humanoid robots in supporting the learning of pupils with severe intellectual disabilities.

MMP-1 activation contributes to airway smooth muscle growth and asthma severity (2016)
Journal Article
Naveed, S., Clements, D., Jackson, D. J., Philp, C., Billington, C. K., Soomro, I. N., …Johnson, S. R. (2017). MMP-1 activation contributes to airway smooth muscle growth and asthma severity. American Journal of Respiratory and Critical Care Medicine, 195(8), 1000-1009. https://doi.org/10.1164/rccm.201604-0822OC

Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity. Methods: Patients with stable ast... Read More about MMP-1 activation contributes to airway smooth muscle growth and asthma severity.

Supporting Japanese mothers of children with ADHD: cultural adaptation of the New Forest Parent Training Programme (2016)
Journal Article
Shimabukuro, S., Daley, D., Thompson, M., Laver-Bradbury, C., Nakanishi, E., & Tripp, G. (2017). Supporting Japanese mothers of children with ADHD: cultural adaptation of the New Forest Parent Training Programme. Japanese Psychological Research, 59(1), 35-48. https://doi.org/10.1111/jpr.12140

International practice guidelines recommend medication and behavioral intervention as evidenced-based treatments for attention deficit hyperactivity disorder (ADHD). Currently in Japan, the availability of non pharmacological interventions for ADHD i... Read More about Supporting Japanese mothers of children with ADHD: cultural adaptation of the New Forest Parent Training Programme.

Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI (2016)
Journal Article
Lam, C., Chaddock, G., Marciani, L., Costigan, C., Cox, E., Hoad, C., …Spiller, R. C. (in press). Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI. American Journal of Gastroenterology, https://doi.org/10.1038/ajg.2016.538

OBJECTIVES: Non-invasive biomarkers which identify different mechanisms of disease in subgroups of irritable bowel syndrome (IBS) could be valuable. Our aim was to seek useful magnetic resonance imaging (MRI) parameters that could distinguish each IB... Read More about Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI.

Feasibility of an online intervention (STAK-D) to promote physical activity in children with type 1 diabetes: protocol for a randomised controlled trial (2016)
Journal Article
Blake, H., Quirk, H., Leighton, P., Randell, T., Greening, J., Guo, B., & Glazebrook, C. (2016). Feasibility of an online intervention (STAK-D) to promote physical activity in children with type 1 diabetes: protocol for a randomised controlled trial. Trials, 17(283), https://doi.org/10.1186/s13063-016-1719-0

Background: Regular physical activity has important health benefits for children with type 1 diabetes mellitus (T1DM), yet children and their parents face barriers to participation such as lack of self-efficacy or concerns around hypoglycaemia. Multi... Read More about Feasibility of an online intervention (STAK-D) to promote physical activity in children with type 1 diabetes: protocol for a randomised controlled trial.

Can body composition be used to optimize the dose of platinum chemotherapy in lung cancer? A feasibility study (2016)
Journal Article
Crosby, V., D'Souza, C., Bristow, C., Proffitt, A., Hussain, A., Potter, V., …Wilcock, A. (in press). Can body composition be used to optimize the dose of platinum chemotherapy in lung cancer? A feasibility study. Supportive Care in Cancer, 25(4), https://doi.org/10.1007/s00520-016-3518-2

Purpose Current methods of dosing platinum-based chemotherapy are suboptimal. Potentially, taking lean body mass into account may help. To inform the design of a future study, we first examined the feasibility and acceptability of such an approach us... Read More about Can body composition be used to optimize the dose of platinum chemotherapy in lung cancer? A feasibility study.

A study of the validity and the reliability of the Geriatric Anxiety Inventory in screening for anxiety after stroke in older inpatients (2016)
Journal Article
Kneebone, I. I., Fife-Schaw, C., Lincoln, N., & Harder, H. (2016). A study of the validity and the reliability of the Geriatric Anxiety Inventory in screening for anxiety after stroke in older inpatients. Clinical Rehabilitation, 30(12), https://doi.org/10.1177/0269215515619661

Objectives: To investigate the validity and reliability of the Geriatric Anxiety Inventory in screening for anxiety in older inpatients post-stroke. Design: Longitudinal. Subjects: A total of 81 inpatients with stroke aged 65 years or older we... Read More about A study of the validity and the reliability of the Geriatric Anxiety Inventory in screening for anxiety after stroke in older inpatients.

Surgery Versus 5% Imiquimod for Nodularand Superficial Basal Cell Carcinoma: 5-Year Results of the SINSRandomized Controlled Trial (2016)
Journal Article
Williams, H. C., Bath-Hextall, F., Ozolins, M., Armstrong, S. J., Colver, G. B., Perkins, W., …Surgery versus Imiquimod forNodular and Superficial basal cell carcinoma (SINS) study group. (2017). Surgery Versus 5% Imiquimod for Nodularand Superficial Basal Cell Carcinoma: 5-Year Results of the SINSRandomized Controlled Trial. Journal of Investigative Dermatology, 137(3), 614-619. https://doi.org/10.1016/j.jid.2016.10.019

© 2016 The Authors We previously reported modest clinical 3-year benefit for topical imiquimod compared with surgery for superficial or nodular basal cell carcinoma at low-risk sites in our noninferiority randomized controlled SINS trial. Here we rep... Read More about Surgery Versus 5% Imiquimod for Nodularand Superficial Basal Cell Carcinoma: 5-Year Results of the SINSRandomized Controlled Trial.

Supporting Kids with diabetes In Physical activity (SKIP): protocol for a randomized feasibility trial of an online intervention to promote physical activity in children with type 1 diabetes (2016)
Presentation / Conference
Blake, H., Quirk, H., Leighton, P., Randell, T., Greening, J., Knox, E., …Glazebrook, C. (2016, December). Supporting Kids with diabetes In Physical activity (SKIP): protocol for a randomized feasibility trial of an online intervention to promote physical activity in children with type 1 diabetes. Paper presented at UK Society for Behavioural Medicine 12th Annual Scientific Meeting

Perception of first respiratory infection with Pseudomonas aeruginosa by people with cystic fibrosis and those close to them: an online qualitative study (2016)
Journal Article
Palser, S. C., Rayner, O. C., Leighton, P., & Smyth, A. R. (2016). Perception of first respiratory infection with Pseudomonas aeruginosa by people with cystic fibrosis and those close to them: an online qualitative study. BMJ Open, 6(12), Article e012303. https://doi.org/10.1136/bmjopen-2016-012303

Background: People with cystic fibrosis (CF) are susceptible to respiratory infection with Pseudomonas aeruginosa (PA), which may become chronic if initial eradication fails. Environmental acquisition and person-to-person transmission can occur. Resp... Read More about Perception of first respiratory infection with Pseudomonas aeruginosa by people with cystic fibrosis and those close to them: an online qualitative study.

Long-term topical corticosteroid use and risk of skin cancer: a systematic review protocol (2016)
Journal Article
Ratib, S., Burden-Teh, E., Leonardi-Bee, J., Harwood, C., & Bath-Hextall, F. (2016). Long-term topical corticosteroid use and risk of skin cancer: a systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports, 14(12), https://doi.org/10.11124/JBISRIR-2016-003226

Review question/objective: The objective of this systematic review is to synthesize the best available research evidence to determine the risk of skin cancer in patients on long-term use of topical corticosteroids. Specifically the review question is... Read More about Long-term topical corticosteroid use and risk of skin cancer: a systematic review protocol.

Operationalising cognitive fatigability in multiple sclerosis: a Gordian knot that can be cut? (2016)
Journal Article
Harrison, A. M., das Nair, R., & Moss-Morris, R. (in press). Operationalising cognitive fatigability in multiple sclerosis: a Gordian knot that can be cut?. Multiple Sclerosis Journal - Experimental, Translational and Clinical, https://doi.org/10.1177/1352458516681862

Background: Researchers have attempted to operationalise objective measures of cognitive fatigability in multiple sclerosis (MS) to overcome the perceived subjectivity of patient-reported outcomes of fatigue (PROs). Measures of cognitive fatigability... Read More about Operationalising cognitive fatigability in multiple sclerosis: a Gordian knot that can be cut?.

Using Acoustic Simulations of Hearing Loss to Describe Health States: Are they Feasible and Reliable to use? (2016)
Journal Article
Williams, N., Pierzycki, R., Akeroyd, M. A., & Kitterick, P. T. (2016). Using Acoustic Simulations of Hearing Loss to Describe Health States: Are they Feasible and Reliable to use?. Value in Health, 19(7), A383. https://doi.org/10.1016/j.jval.2016.09.212

Objectives Decisions about which treatments to provide in publicly-funded healthcare systems are partly based on the preferences of the general public. Preferences can be obtained by describing a health state before and after a treatment in word... Read More about Using Acoustic Simulations of Hearing Loss to Describe Health States: Are they Feasible and Reliable to use?.

Pre-market version of a commercially available hearing instrument with a tinnitus sound generator: feasibility of evaluation in a clinical trial. (2016)
Journal Article
Sereda, M., Davies, J., & Hall, D. A. (in press). Pre-market version of a commercially available hearing instrument with a tinnitus sound generator: feasibility of evaluation in a clinical trial. International Journal of Audiology, https://doi.org/10.1080/14992027.2016.1254822

OBJECTIVE: This report considers feasibility of conducting a UK trial of combination devices for tinnitus, using data from the study which evaluated different listener programmes available within the pre-market version of Oticon Alta with Tinnitus S... Read More about Pre-market version of a commercially available hearing instrument with a tinnitus sound generator: feasibility of evaluation in a clinical trial..