Skip to main content

Research Repository

Advanced Search

All Outputs (1)

Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines (2016)
Journal Article
Cousin, D., Zhang, J., Hummersone, M. G., Matthews, C. S., Frigerio, M., Bradshaw, T., & Stevens, M. F. (2016). Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines. MedChemComm, 7(12), 2332-2343. doi:10.1039/c6md00384b

Synthetic routes to 3-substituted imidazo[5,1-d]-1,2,3,5-tetrazines structurally related to temozolomide were explored. Interaction of 4-diazoimidazole-5-carboxamide with an isocyanate afforded high product yields when the isocyanate was available in... Read More about Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines.