PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells

Rogers, Samuel; Fey, Dirk; McCloy, Rachael A.; Parker, Benjamin L.; Mitchell, Nicholas J.; Payne, Richard J.; Daly, Roger J.; James, David E.; Caldon, C. Elizabeth; Watkins, D. Neil; Croucher, David R.; Burgess, Andrew

doi:10.1242/jcs.179754

All Outputs (3)

One-pot ligation-oxidative deselenization at selenocysteine and selenocystine (2016)
Journal Article
Payne, R. J., Mitchell, N. J., Kulkarni, S. S., Wang, S., & Malins, L. (2017). One-pot ligation-oxidative deselenization at selenocysteine and selenocystine. Chemistry - A European Journal, 23(4), 946-952. https://doi.org/10.1002/chem.201604709

The use of native chemical ligation at selenocysteine (Sec) with peptide thioesters and additive-free selenocystine ligation with peptides bearing phenyl selenoesters, in concert with one-pot oxidative deselenization chemistry, is described. These ap... Read More about One-pot ligation-oxidative deselenization at selenocysteine and selenocystine.

Single addition of an allyl amine monomer enables access to end-functionalized RAFT polymers via native chemical ligation (2016)
Journal Article
Isahak, N., Gody, G., Malins, L. R., Mitchell, N. J., Payne, R. J., & Perrier, S. (in press). Single addition of an allyl amine monomer enables access to end-functionalized RAFT polymers via native chemical ligation. Chemical Communications, 52, https://doi.org/10.1039/C6CC06010B

A novel method for the introduction of a single protected amine-functional monomer at the chain end of RAFT polymers has been developed. This monomer addition, in concert with native chemical ligation, facilitated the development of a simple and vers... Read More about Single addition of an allyl amine monomer enables access to end-functionalized RAFT polymers via native chemical ligation.

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells (2016)
Journal Article
Rogers, S., Fey, D., McCloy, R. A., Parker, B. L., Mitchell, N. J., Payne, R. J., …Burgess, A. (2016). PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells. Journal of Cell Science, 129(7), 1340-1354. https://doi.org/10.1242/jcs.179754

Entry into mitosis is driven by the phosphorylation of thousands of substrates, under the master control of Cdk1. During entry into mitosis, Cdk1, in collaboration with MASTL kinase, represses the activity of the major mitotic protein phosphatases, P... Read More about PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells.