All Outputs (3)

Prevailing PA mutation K356R in avian influenza H9N2 virus increases mammalian replication and pathogenicity (2016)
Journal Article
Xu, G., Zhang, X., Gao, W., Wang, C., Wang, J., Sun, H., …Pu, J. (in press). Prevailing PA mutation K356R in avian influenza H9N2 virus increases mammalian replication and pathogenicity. Journal of Virology, 90(18), https://doi.org/10.1128/JVI.00883-16

Adaptation of the viral polymerase complex comprising PB1, PB2, and PA is necessary for efficient influenza A virus replication in new host species. We found that PA mutation K356R (PA-K356R) has become predominant since 2014 in avian H9N2 viruses in... Read More about Prevailing PA mutation K356R in avian influenza H9N2 virus increases mammalian replication and pathogenicity.

Transmission and pathogenicity of novel reassortants derived from Eurasian avian-like and 2009 pandemic H1N1 influenza viruses in mice and guinea pigs (2016)
Journal Article
Kong, W., Liu, Q., Sun, Y., Wang, Y., Gao, H., Liu, L., …Liu, J. (2016). Transmission and pathogenicity of novel reassortants derived from Eurasian avian-like and 2009 pandemic H1N1 influenza viruses in mice and guinea pigs. Scientific Reports, 6, Article 27067. https://doi.org/10.1038/srep27067

Given the present extensive co-circulation in pigs of Eurasian avian-like (EA) swine H1N1 and 2009 pandemic (pdm/09) H1N1 viruses, reassortment between them is highly plausible but largely uncharacterized. Here, experimentally co-infected pigs with a... Read More about Transmission and pathogenicity of novel reassortants derived from Eurasian avian-like and 2009 pandemic H1N1 influenza viruses in mice and guinea pigs.

Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets (2016)
Journal Article
Sun, H., Pu, J., Wei, Y., Sun, Y., Hu, J., Liu, L., …Liu, J. (2016). Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets. Journal of Virology, 90(14), https://doi.org/10.1128/JVI.00127-16

Since May 2014, highly pathogenic avian influenza H5N6 virus has been reported to cause six severe human infections three of which were fatal. The biological properties of this subtype, in particular its relative pathogenicity and transmissibility in... Read More about Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets.