All Outputs (4)

Healthy ageing of cloned sheep (2016)
Journal Article
Sinclair, K. D., Corr, S., Gutierrez, C. G., Fisher, P., Lee, J., Rathbone, A., …Gardner, D. (2016). Healthy ageing of cloned sheep. Nature Communications, 7, 1-10. https://doi.org/10.1038/ncomms12359

The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detri... Read More about Healthy ageing of cloned sheep.

Epigenetics and developmental programming of welfare and production traits in farm animals (2016)
Journal Article
Sinclair, K. D., Rutherford, K., Wallace, J., Brameld, J., Stöger, R., Alberio, R., …Dwyer, C. (in press). Epigenetics and developmental programming of welfare and production traits in farm animals. Reproduction, Fertility and Development, 28(10), https://doi.org/10.1071/RD16102

The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referr... Read More about Epigenetics and developmental programming of welfare and production traits in farm animals.

Molecular determinants of a competent bovine corpus luteum: first- vs final-wave dominant follicles (2016)
Journal Article
Gregson, E., Webb, R., Sheldrick, E. L., Campbell, B. K., Mann, G. E., Liddell, S., & Sinclair, K. D. (2016). Molecular determinants of a competent bovine corpus luteum: first- vs final-wave dominant follicles. Reproduction, 151(6), 563-575. https://doi.org/10.1530/REP-15-0415

Reproductive management in cattle requires the synchrony of follicle development and oestrus before insemination. However, ovulation of follicles that have not undergone normal physiological maturation can lead to suboptimal luteal function. Here, we... Read More about Molecular determinants of a competent bovine corpus luteum: first- vs final-wave dominant follicles.

The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals (2016)
Journal Article
Lea, R. G., Amezaga, M. R., Loup, B., Mandon- Pépin, B., Stefansdottir, A., Filis, P., …Fowler, P. . A. (2016). The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals. Scientific Reports, 6, 22279. https://doi.org/10.1038/srep22279

The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on... Read More about The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals.