All Outputs (2)

Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study (2016)
Journal Article
Nicoletti, P., Aithal, G. P., Bjornsson, E. S., Andrade, R. J., Sawle, A., Arrese, M., …Daly, A. K. (2017). Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study. Gastroenterology, 152(5), 1078-1089. https://doi.org/10.1053/j.gastro.2016.12.016

Background & aims: We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors. Methods: We performed a GWAS of 862 pe... Read More about Association of liver injury from specific drugs, or groups of drugs, with polymorphisms in HLA and other genes in a genome-wide association study.

Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms? (2016)
Journal Article
Grove, J. I., Austin, M., Tibble, J., Aithal, G. P., & Verma, S. (2016). Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms?. Annals of Hepatology, 15(2), 277-282

Multiple genetic and environmental factors interact to determine an individual?s predisposition to non-alcoholic fatty liver disease and its phenotypic characteristics. Association studies have found a number of alleles associated with the developmen... Read More about Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms?.