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All Outputs (2)

Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds (2016)
Journal Article
Ryan, J., Šiaučiulis, M., Gomm, A., Macia, B., O'Reilly, E., & Caprio, V. (in press). Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds. Journal of the American Chemical Society, 138(49), https://doi.org/10.1021/jacs.6b07024

The expanding “toolbox” of biocatalysts opens new opportunities to redesign synthetic strategies to target molecules by incorporating a key enzymatic step into the synthesis. Herein, we describe a general biocatalytic approach for the enantioselectiv... Read More about Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds.

A new generation of smart amine donors for transaminase-mediated biotransformations (2016)
Journal Article
Gomm, A., Lewis, W., Green, A. P., & O'Reilly, E. (2016). A new generation of smart amine donors for transaminase-mediated biotransformations. Chemistry - A European Journal, 22(36), 12692-12695. https://doi.org/10.1002/chem.201603188

The application of ω-transaminase biocatalysts for the synthesis of optically pure chiral amines presents a number of challenges, including difficulties associated with displacing the challenging reaction equilibria. Herein, we report a highly effect... Read More about A new generation of smart amine donors for transaminase-mediated biotransformations.