Backbone NMR reveals allosteric signal transduction networks in the ?1-adrenergic receptor

Isogai, Shin; Deupi, Xavier; Opitz, Christian; Heydenreich, Franziska M.; Tsai, Ching-Ju; Brueckner, Florian; Schertler, Gebhard F.X.; Veprintsev, Dmitry B.; Grzesiek, Stephan

doi:10.1038/nature16577

All Outputs (2)

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region (2016)
Journal Article
Venkatakrishnan, A., Deupi, X., Lebon, G., Heydenreich, F. M., Flock, T., Miljus, T., …Madan Babu, M. (2016). Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region. Nature, 536(7617), 484–487. https://doi.org/10.1038/nature19107

Backbone NMR reveals allosteric signal transduction networks in the ?1-adrenergic receptor (2016)
Journal Article
Isogai, S., Deupi, X., Opitz, C., Heydenreich, F. M., Tsai, C., Brueckner, F., …Grzesiek, S. (in press). Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor. Nature, 530(7589), https://doi.org/10.1038/nature16577

G protein-coupled receptors (GPCRs) are physiologically important transmembrane signalling proteins that trigger intracellular responses upon binding of extracellular ligands. Despite recent breakthroughs in GPCR crystallography1–3, the details of li... Read More about Backbone NMR reveals allosteric signal transduction networks in the ?1-adrenergic receptor.