All Outputs (2)

Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes (2016)
Journal Article
D’Archivio, S., & Wickstead, B. (2017). Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes. Journal of Cell Biology, 216(2), 379-391. https://doi.org/10.1083/jcb.201608043

Kinetochores are multiprotein complexes that couple eukaryotic chromosomes to the mitotic spindle to ensure proper segregation. The model for kinetochore assembly is conserved between humans and yeast, and homologues of several components are widely... Read More about Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes.

The family-specific ?4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition (2016)
Journal Article
Patel, J. T., Belsham, H. R., Rathbone, A. J., Wickstead, B., Gell, C., & Friel, C. T. (2016). The family-specific ?4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition. Open Biology, 6(10), Article 160223. https://doi.org/10.1098/rsob.160223

Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice. The microtubule depolymerizing kinesin MCAK has been shown to specifically recognize... Read More about The family-specific ?4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition.