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All Outputs (8)

Is clarithromycin a potential treatment for cachexia in people with lung cancer?: a feasibility study (2016)
Journal Article
Awan, S., Crosby, V., Potter, V., Hennig, I., Baldwin, D., Ndlovu, M., …Wilcock, A. (2017). Is clarithromycin a potential treatment for cachexia in people with lung cancer?: a feasibility study. Lung Cancer, 104, https://doi.org/10.1016/j.lungcan.2016.12.010

Clarithromycin may improve cachexia and survival in non-small cell lung cancer (NSCLC), but adequately controlled data are lacking. This study was undertaken primarily to inform the feasibility and scale of a phase III trial. Eligible consenting pati... Read More about Is clarithromycin a potential treatment for cachexia in people with lung cancer?: a feasibility study.

Can body composition be used to optimize the dose of platinum chemotherapy in lung cancer? A feasibility study (2016)
Journal Article
Crosby, V., D'Souza, C., Bristow, C., Proffitt, A., Hussain, A., Potter, V., …Wilcock, A. (in press). Can body composition be used to optimize the dose of platinum chemotherapy in lung cancer? A feasibility study. Supportive Care in Cancer, 25(4), https://doi.org/10.1007/s00520-016-3518-2

Purpose Current methods of dosing platinum-based chemotherapy are suboptimal. Potentially, taking lean body mass into account may help. To inform the design of a future study, we first examined the feasibility and acceptability of such an approach us... Read More about Can body composition be used to optimize the dose of platinum chemotherapy in lung cancer? A feasibility study.

Psychometric properties of a generic, patient-centred palliative care outcome measure of symptom burden for people with progressive long term neurological conditions (2016)
Journal Article
Gao, W., Crosby, V., Wilcock, A., Burman, R., Silber, E., Hepgul, N., …Higginson, I. J. (2016). Psychometric properties of a generic, patient-centred palliative care outcome measure of symptom burden for people with progressive long term neurological conditions. PLoS ONE, 11(10), 1-15. https://doi.org/10.1371/journal.pone.0165379

Background There is no standard palliative care outcome measure for people with progressive long term neurological conditions (LTNC). This study aims to determine the psychometric properties of a new 8-item palliative care outcome scale of symptom b... Read More about Psychometric properties of a generic, patient-centred palliative care outcome measure of symptom burden for people with progressive long term neurological conditions.

Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes (2016)
Journal Article
Murton, A. J., Maddocks, M., Stephens, F. B., Marimuthu, K., England, R., & Wilcock, A. (in press). Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes. Clinical Lung Cancer, https://doi.org/10.1016/j.cllc.2016.06.003

Introduction: Loss of muscle is common in patients with advanced non-small cell lung cancer (NSCLC), and contributes to the high morbidity and mortality of this group. The exact mechanisms behind the loss of muscle are unclear. Patients and methods... Read More about Consequences of late-stage non-small cell lung cancer cachexia on muscle metabolic processes.

Pharmacovigilance in hospice/palliative care: the net immediate and short-term effects of dexamethasone for anorexia (2016)
Journal Article
Hatano, Y., Moroni, M., Wilcock, A., Quinn, S., Csikós, Á., Allan, S. G., …Currow, D. C. (2016). Pharmacovigilance in hospice/palliative care: the net immediate and short-term effects of dexamethasone for anorexia. BMJ Supportive and Palliative Care, 6(3), https://doi.org/10.1136/bmjspcare-2015-001037

Objectives Loss of appetite is prevalent in palliative care and distressing for patients and families. Therapies include corticosteroids or progestogens. This study explores the net effect of dexamethasone on anorexia. Methods Prospective data were... Read More about Pharmacovigilance in hospice/palliative care: the net immediate and short-term effects of dexamethasone for anorexia.

How integrated are neurology and palliative care services? Results of a multicentre mapping exercise (2016)
Journal Article
van Vliet, L. M., Gao, W., DiFrancesco, D., Crosby, V., Wilcock, A., Byrne, A., …Higginson, I. J. (in press). How integrated are neurology and palliative care services? Results of a multicentre mapping exercise. BMC Neurology, 16, https://doi.org/10.1186/s12883-016-0583-6

Background: Patients affected by progressive long-term neurological conditions might benefit from specialist palliative care involvement. However, little is known on how neurology and specialist palliative care services interact. This study aimed to... Read More about How integrated are neurology and palliative care services? Results of a multicentre mapping exercise.

Advance care planning, a multi-centre cluster randomised clinical trial: the research protocol of the ACTION study (2016)
Journal Article
Rietjens, J. A. C., Korfage, I. J., Dunleavy, L., Preston, N. J., Jabbarian, L. J., Christensen, C. A., …van der Heide, A. (2016). Advance care planning, a multi-centre cluster randomised clinical trial: the research protocol of the ACTION study. BMC Cancer, 16(264), https://doi.org/10.1186/s12885-016-2298-x

Background: Awareness of preferences regarding medical care should be a central component of the care of patients with advanced cancer. Open communication can facilitate this but can occur in an ad hoc or variable manner. Advance care planning (ACP)... Read More about Advance care planning, a multi-centre cluster randomised clinical trial: the research protocol of the ACTION study.

Lung cancer diagnosed following an emergency admission: Mixed methods study of the management, outcomes and needs and experiences of patients and carers (2016)
Journal Article
Wilcock, A., Crosby, V., Hussain, A., McKeever, T. M., Manderson, C., Farnan, S., …Seymour, J. (2016). Lung cancer diagnosed following an emergency admission: Mixed methods study of the management, outcomes and needs and experiences of patients and carers. Respiratory Medicine, 114, 38-45. https://doi.org/10.1016/j.rmed.2016.03.006

Background In the UK, although 40% of patients with lung cancer are diagnosed following an emergency admission (EA), data is limited on their needs and experiences as they progress through diagnostic and treatment pathways. Methods Prospective... Read More about Lung cancer diagnosed following an emergency admission: Mixed methods study of the management, outcomes and needs and experiences of patients and carers.