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Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation? (2016)
Journal Article
Steenblock, C., de Celis, M. F. R., Androutsellis-Theotokis, A., Sue, M., Delgadillo Silva, L. F., Eisenhofer, G., …Bornstein, S. R. (2017). Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?. Molecular and Cellular Endocrinology, 441, https://doi.org/10.1016/j.mce.2016.09.011

The adrenal gland is a highly plastic organ with the capacity to adapt the body homeostasis to different physiological needs. The existence of stem-like cells in the adrenal cortex has been revealed in many studies. Recently, we identified and charac... Read More about Adrenal cortical and chromaffin stem cells: Is there a common progeny related to stress adaptation?.

Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination (2016)
Journal Article
Toutouna, L., Nikolakopoulou, P., Poser, S. W., Masjkur, J., Arps-Forker, C., Troullinaki, M., …Androutsellis-Theotokis, A. (2016). Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination. Brain Research, 1642, https://doi.org/10.1016/j.brainres.2016.03.014

Hes3 is a component of the STAT3-Ser/Hes3 Signaling Axis controlling the growth and survival of neural stem cells and other plastic cells. Pharmacological activation of this pathway promotes neuronal rescue and behavioral recovery in models of ischem... Read More about Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination.

Endocrine pancreas development and regeneration: noncanonical ideas from neural stem cell biology (2016)
Journal Article
Masjkur, J., Poser, S. W., Nikolakopoulou, P., Chrousos, G., McKay, R. D., Bornstein, S. R., …Androutsellis-Theotokis, A. (2016). Endocrine pancreas development and regeneration: noncanonical ideas from neural stem cell biology. Diabetes, 65(2), https://doi.org/10.2337/db15-1099

Loss of insulin-producing pancreatic islet β-cells is a hallmark of type 1 diabetes. Several experimental paradigms demonstrate that these cells can, in principle, be regenerated from multiple endogenous sources using signaling pathways that are also... Read More about Endocrine pancreas development and regeneration: noncanonical ideas from neural stem cell biology.

The effects of stress on brain and adrenal stem cells (2016)
Journal Article
de Celis, M. F. R., Bornstein, S. R., Androutsellis-Theotokis, A., Andoniadou, C. L., Licinio, J., Wong, M., & Ehrhart-Bornstein, M. (in press). The effects of stress on brain and adrenal stem cells. Molecular Psychiatry, 21(5), https://doi.org/10.1038/mp.2015.230

The brain and adrenal are critical control centers that maintain body homeostasis under basal and stress conditions, and orchestrate the body’s response to stress. It is noteworthy that patients with stress-related disorders exhibit increased vulnera... Read More about The effects of stress on brain and adrenal stem cells.

STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system? (2016)
Journal Article
Nikolakopoulou, P., Poser, S., Masjkur, J., Fernandez Rubin de Celis, M., Toutouna, L., Andoniadou, C., …Androutsellis-Theotokis, A. (2016). STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?. Hormone and Metabolic Research, 48(2), https://doi.org/10.1055/s-0041-111699

The endocrine system involves communication among different tissues in distinct organs, including the pancreas and components of the Hypothalamic- Pituitary-Adrenal Axis. The molecular mechanisms underlying these complex interactions are a subject of... Read More about STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?.