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All Outputs (8)

A paper-based in vitro model for on-chip investigation of the human respiratory system (2016)
Journal Article
Rahimi, R., Htwe, S. S., Ochoa, M., Donaldson, A., Zieger, M., Sood, R., …Ziaie, B. (in press). A paper-based in vitro model for on-chip investigation of the human respiratory system. Lab on a Chip, 16(22), https://doi.org/10.1039/C6LC00866F

Culturing cells at the air–liquid interface (ALI) is essential for creating functional in vitro models of lung tissues. We present the use of direct-patterned laser-treated hydrophobic paper as an effective semi-permeable membrane, ideal for ALI cell... Read More about A paper-based in vitro model for on-chip investigation of the human respiratory system.

Effective antigen presentation to helper T cells by human eosinophils (2016)
Journal Article
Farhan, R. K., Vickers, M. A., Ghaemmaghami, A. M., Hall, A. M., Barker, R. N., & Walsh, G. M. (in press). Effective antigen presentation to helper T cells by human eosinophils. Immunology, https://doi.org/10.1111/imm.12658

Although eosinophils are inflammatory cells, there is increasing attention on their immunomodulatory roles. For example, murine eosinophils can present antigen to CD4+ T helper (Th) cells, but it remains unclear whether human eosinophils also have th... Read More about Effective antigen presentation to helper T cells by human eosinophils.

Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation (2016)
Journal Article
Aldajani, W. A., Salazar, F., Sewell, H. F., Knox, A., & Ghaemmaghami, A. M. (2016). Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation. Oncotarget, 7(36), https://doi.org/10.18632/oncotarget.11586

Indoleamine 2,3-dioxygenase (IDO) catalyzes the degradation of tryptophan, which plays a critical role in immune suppression through regulating the production of a series of metabolites that are generally referred to as kynurenines. It has become inc... Read More about Expression and regulation of immune-modulatory enzyme Indoleamine 2,3-dioxygenase (IDO) by human airway epithelial cells and its effect on T cell activation.

The impact of surface chemistry modification on macrophage polarisation (2016)
Journal Article
Rostam, H., Singh, S., Salazar, F., Magennis, P., Hook, A. L., Singh, T., …Ghaemmaghami, A. M. (2016). The impact of surface chemistry modification on macrophage polarisation. Immunobiology, 221(11), 1237-1246. https://doi.org/10.1016/j.imbio.2016.06.010

Macrophages are innate immune cells that have a central role in combating infection and maintaining tissue homeostasis. They exhibit remarkable plasticity in response to environmental cues. At either end of a broad activation spectrum are pro-inflamm... Read More about The impact of surface chemistry modification on macrophage polarisation.

A low-cost paper-based model for on-chip human respiratory system studies (2016)
Conference Proceeding
Rahimi, R., Ochoa, M., Htwe, S. S., Donaldson, A., Zieger, M., Dokmeci, M. R., …Ziaie, B. (2016). A low-cost paper-based model for on-chip human respiratory system studies. In Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016 (206-209). https://doi.org/10.31438/trf.hh2016.56

© 2016 TRF We present the use of hydrophobic paper as an effective semipermeable membrane, ideal for air-liquid interface cell culture applications. The surface properties of the paper is modified through selective CO2 laser-assisted scrubbing to cre... Read More about A low-cost paper-based model for on-chip human respiratory system studies.

Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings (2016)
Journal Article
Knopf-Marques, H., Singh, S., Htwe, S. S., Wolfova, L., Buffa, R., Bacharouche, J., …Lavalle, P. (2016). Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings. Biomacromolecules, 17(6), 2189-2198. https://doi.org/10.1021/acs.biomac.6b00429

This study aims to design an optimal polyelectrolyte multilayer film of poly-L-lysine (PLL) and hyaluronic acid(HA) as an anti-inflammatory cytokine release system in order to decrease the implant failure due to any immune reactions. The chemical mod... Read More about Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings.

Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response (2016)
Journal Article
Vishwakarma, A., Bhise, N. S., Evangelista, M. B., Rouwkema, J., Dokmeci, M. R., Ghaemmaghami, A. M., …Khademhosseini, A. (2016). Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response. Trends in Biotechnology, 34(6), 470-482. https://doi.org/10.1016/j.tibtech.2016.03.009

Current state-of-the-art biomedical implants and tissue engineering methods promise technologies to improve or even restore the function of diseased organs. However, one of the biggest challenges to clinical success is the lack of functional integrat... Read More about Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response.

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications (2016)
Journal Article
Alvarez, M. M., Liu, J. C., Trujillo-de Santiago, G., Cha, B. H., Vishwakarma, A., Ghaemmaghami, A. M., & Khademhosseini, A. (2016). Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications. Journal of Controlled Release, 240, 349-363. https://doi.org/10.1016/j.jconrel.2016.01.026

Macrophages are key players in many physiological scenarios including tissue homeostasis. In response to injury, typically the balance between macrophage sub-populations shifts from an M1 phenotype (pro-inflammatory) to an M2 phenotype (anti-inflamma... Read More about Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications.