Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth

McIntyre, Alan; Hulikova, Alzbeta; Ledaki, Ioanna; Snell, Cameron; Singleton, Dean; Steers, Graham; Seden, Peter; Jones, Dylan; Bridges, Esther; Wigfield, Simon; Li, Ji-Liang; Russell, Angela; Swietach, Pawel; Harris, Adrian L.

doi:10.1158/0008-5472.CAN-15-1862

All Outputs (3)

Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia (2016)
Journal Article
Haider, S., MCINTYRE, A., van Stiphout, R. G., Winchester, L. M., Wigfield, S., Harris, A. L., & Buffa, F. M. (2016). Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia. Genome Biology, 17(1), Article 140. https://doi.org/10.1186/s13059-016-0999-8

The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer (2016)
Journal Article
da Motta, L. L., Ledaki, I., Purshouse, K., Haider, S., de Bastiani, M., Baban, D., …McIntyre, A. (2017). The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer. Oncogene, 36, 122-132. https://doi.org/10.1038/onc.2016.184

The availability of bromodomain and extra-terminal inhibitors (BETi) has enabled translational epigenetic studies in cancer. BET proteins regulate transcription by selectively recognizing acetylated lysine residues on chromatin. BETi compete with thi... Read More about The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth (2016)
Journal Article
McIntyre, A., Hulikova, A., Ledaki, I., Snell, C., Singleton, D., Steers, G., …Harris, A. L. (2016). Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth. Cancer Research, 76(13), 3744-3755. https://doi.org/10.1158/0008-5472.CAN-15-1862

Tumor hypoxia is associated clinically with therapeutic resistance and poor patient outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor growth. In this study, we investigated the... Read More about Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.