Skip to main content

Research Repository

Advanced Search

All Outputs (3)

Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches (2016)
Journal Article
Onyido, E. K., Sweeney, E., & Nateri, A. S. (2016). Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches. Molecular Cancer, 15(56), https://doi.org/10.1186/s12943-016-0541-3

Over the past few years, microRNAs (miRNAs) have not only emerged as integral regulators of gene expression at the post-transcriptional level but also respond to signalling molecules to affect cell function(s). miRNAs crosstalk with a variety of the... Read More about Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches.

Spheroid-Formation (Colonosphere) Assay for in Vitro Assessment and Expansion of Stem Cells in Colon Cancer (2016)
Journal Article
Shaheen, S., Ahmed, M., Lorenzi, F., & Nateri, A. S. (2016). Spheroid-Formation (Colonosphere) Assay for in Vitro Assessment and Expansion of Stem Cells in Colon Cancer. Stem Cell Reviews and Reports, 12(4), 492-499. https://doi.org/10.1007/s12015-016-9664-6

Colorectal cancers (CRCs) form a disorganized hierarchy of heterogeneous cell populations on which current chemotherapy regimens fail to exert their distinctive cytotoxicity. A small sub-population of poorly differentiated cancer stem-like cells (CSC... Read More about Spheroid-Formation (Colonosphere) Assay for in Vitro Assessment and Expansion of Stem Cells in Colon Cancer.

Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture (2016)
Journal Article
Lorenzi, F., Babaei-Jadidi, R., Sheard, J., Spencer-Dene, B., & Nateri, A. S. (2016). Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture. Molecular Therapy - Methods and Clinical Development, 3, 16024. https://doi.org/10.1038/mtm.2016.24

Colorectal cancer (CRC) is one of the top three cancer-related causes of death worldwide. FBXW7 is a known tumor-suppressor gene, commonly mutated in CRC and in a variety of other epithelial tumors. Low expression of FBXW7 is also associated with poo... Read More about Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture.