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4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor (2015)
Journal Article
Mistry, S. N., Jörg, M., Lim, H., Vinh, N. B., Sexton, P. M., Capuano, B., …Scammells, P. J. (2016). 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor. Journal of Medicinal Chemistry, 59(1), 388-409. https://doi.org/10.1021/acs.jmedchem.5b01562

Positive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (M1 mAChR) are a promising strategy for the treatment of the cognitive deficits associated with diseases including Alzheimer’s and schizophrenia. Herein, we report the... Read More about 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles (2015)
Journal Article
Rodrigues, M., Russo, L., Aguilo, E., Rodriguez, L., Ott, I., & Pérez-García, L. (2015). Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles. RSC Advances, 6, https://doi.org/10.1039/C5RA21621D

A gold(I) N-heterocyclic carbene 4 from a bis-imidazolium-amphiphile was synthesized and characterized. The cytotoxicity against HT-29 colon carcinoma and MDA-MB-231 breast adenocarcinoma cells was assessed for the NHC complex 4, the imidazolium salt... Read More about Au(I) N-heterocyclic carbenes from bisimidazolium amphiphiles: synthesis, cytotoxicity and incorporation onto gold nanoparticles.

Economic Evaluation of a General Hospital Unit for Older People with Delirium and Dementia (TEAM Randomised Controlled Trial) (2015)
Journal Article
Bradshaw, L. E., Tanajewski, L., Franklin, M., Gkountouras, G., Berdunov, V., Harwood, R. H., …Elliott, R. A. (2015). Economic Evaluation of a General Hospital Unit for Older People with Delirium and Dementia (TEAM Randomised Controlled Trial). PLoS ONE, 10(12), e0140662. https://doi.org/10.1371/journal.pone.0140662

Background One in three hospital acute medical admissions is of an older person with cognitive impairment. Their outcomes are poor and the quality of their care in hospital has been criticised. A specialist unit to care for older people with delir... Read More about Economic Evaluation of a General Hospital Unit for Older People with Delirium and Dementia (TEAM Randomised Controlled Trial).

Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial (2015)
Journal Article
Hawkey, C. J., Allez, M., Clark, M. M., Labopin, M., Lindsay, J. O., Ricart, E., …Farge, D. (2015). Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial. Journal of the American Medical Association, 314(23), 2524-2534. https://doi.org/10.1001/jama.2015.16700

Importance: Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease. Objective: To evaluate the effect of autologous HSCT on refractory Crohn disease. Design, Setting, and Pa... Read More about Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial.

Conceptualising cosmopolitan values in internationalised higher education: a capabilities approach (2015)
Conference Proceeding
Bridges, S. (2015). Conceptualising cosmopolitan values in internationalised higher education: a capabilities approach.

The increasingly internationalised nature of higher education has enhanced the potential for students to benefit from a more diverse student body, yet there are gaps between the rhetoric and ideals of internationalisation and the lived realities for... Read More about Conceptualising cosmopolitan values in internationalised higher education: a capabilities approach.

Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior (2015)
Journal Article
Amin, Y. Y. I., Runager, K., Simoes, F., Celiz, A., Taresco, V., Rossi, R., …Ogaki, R. (2016). Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior. Advanced Materials, 28(7), 1472-1476. https://doi.org/10.1002/adma.201504995

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A novel combinatorial biomolecular nanopatterning method is reported, in which multiple biomolecular ligands can be patterned in multiple nanoscale dimensions on a single surface. The applicability... Read More about Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior.

Supporting adherence for people starting a new medication for a long-term condition through community pharmacies: a pragmatic randomised controlled trial of the New Medicine Service (2015)
Journal Article
Elliott, R. A., Boyd, M. J., Salema, N., Davies, J., Barber, N., Mehta, R. L., …Craig, C. (2016). Supporting adherence for people starting a new medication for a long-term condition through community pharmacies: a pragmatic randomised controlled trial of the New Medicine Service. BMJ Quality and Safety, 25(10), 747-758. https://doi.org/10.1136/bmjqs-2015-004400

Objective: To examine the effectiveness of the New Medicine Service (NMS), a national community pharmacy service to support medicines-taking in people starting a new medicine for a long-term condition, compared with normal practice. Methods: Pragm... Read More about Supporting adherence for people starting a new medication for a long-term condition through community pharmacies: a pragmatic randomised controlled trial of the New Medicine Service.

Thermoresponsive magnetic colloidal gels via surface-initiated polymerisation from functional microparticles (2015)
Journal Article
Braim, S. A., Shakesheff, K. M., Saunders, B. R., & Alexander, C. (2016). Thermoresponsive magnetic colloidal gels via surface-initiated polymerisation from functional microparticles. Journal of Materials Chemistry B, 4(5), https://doi.org/10.1039/c5tb01739d

Novel magnetothermally responsive core-shell microparticles have been synthesized. The aqueous suspensions of these particles exhibit fast thermoreversible fluid-to-gel transitions and retain good magnetic properties. Rheological measurements demonst... Read More about Thermoresponsive magnetic colloidal gels via surface-initiated polymerisation from functional microparticles.

Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the ?-Opioid Receptor (2015)
Journal Article
Schembri, L. S., Stoddart, L. A., Briddon, S. J., Kellam, B., Canals, M., Graham, B., & Scammells, P. J. (2015). Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the ?-Opioid Receptor. Journal of Medicinal Chemistry, 58(24), 9754-9767. https://doi.org/10.1021/acs.jmedchem.5b01664

Fluorescently labeled ligands are useful pharmacological research tools for studying receptor localization, trafficking, and signaling processes via fluorescence imaging. They are also employed in fluorescent binding assays. This study is centered on... Read More about Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the ?-Opioid Receptor.

Receptor crosslinking: a general method to trigger internalization and lysosomal targeting of therapeutic receptor: ligand complexes (2015)
Journal Article
Moody, P. R., Alexander, C., Sayers, E. J., Magnusson, J. P., Borri, P., Watson, P., & Jones, A. T. (2015). Receptor crosslinking: a general method to trigger internalization and lysosomal targeting of therapeutic receptor: ligand complexes. Molecular Therapy, 23(12), 1888-1898. https://doi.org/10.1038/mt.2015.178

A major unmet clinical need is a universal method for subcellular targeting of bioactive molecules to lysosomes. Delivery to this organelle enables either degradation of oncogenic receptors that are overexpressed in cancers, or release of prodrugs fr... Read More about Receptor crosslinking: a general method to trigger internalization and lysosomal targeting of therapeutic receptor: ligand complexes.

Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment (2015)
Journal Article
Magennis, E., Hook, A., Davies, M., Alexander, C., Williams, P., & Alexander, M. R. (2016). Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment. Acta Biomaterialia, 34, 84-92. https://doi.org/10.1016/j.actbio.2015.11.008

Controlling the colonisation of materials by microorganisms is important in a wide range of industries and clinical settings. To date, the underlying mechanisms that govern the interactions of bacteria with material surfaces remain poorly understood,... Read More about Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment.

Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks (2015)
Journal Article
Van Nuffel, S., Parmenter, C. D., Scurr, D. J., Russell, N. A., & Zelzer, M. (in press). Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks. Analyst, 141(1), https://doi.org/10.1039/c5an01743b

Advanced data analysis tools are crucial for the application of ToF-SIMS analysis to biological samples. Here, we demonstrate that by using a training set approach principal components analysis (PCA) can be performed on large 3D ToF-SIMS images of ne... Read More about Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks.

Does a transition in education equate to a transition in practice?: Thai stakeholder’s perceptions of the introduction of the Doctor of Pharmacy programme (2015)
Journal Article
Chanakit, T., Low, B. Y., Wongpoowarak, P., Moolasarn, S., & Anderson, C. (2015). Does a transition in education equate to a transition in practice?: Thai stakeholder’s perceptions of the introduction of the Doctor of Pharmacy programme. BMC Medical Education, 15(1), 1-36. https://doi.org/10.1186/s12909-015-0473-4

Background Pharmacy education and pharmacy practice are facing remarkable changes following new scientific discoveries, evolving patient needs and the requirements of advanced pharmacy competency for practices. Many countries are introducing or unde... Read More about Does a transition in education equate to a transition in practice?: Thai stakeholder’s perceptions of the introduction of the Doctor of Pharmacy programme.

A survey of pharmacy education in Thailand (2015)
Journal Article
Chanakit, T., Low, B. Y., Wongpoowarak, P., Moolasarn, S., & Anderson, C. (2015). A survey of pharmacy education in Thailand. American Journal of Pharmaceutical Education, 78(9), 161. doi:10.5688/ajpe789161