All Outputs (2)

Mathematical neuroscience: from neurons to networks (2015)
Book Chapter
Coombes, S. (2015). Mathematical neuroscience: from neurons to networks. In C. Dogbe (Ed.), Actes du colloque "EDP-Normandie" : Le Havre 2015. Fédération Normandie Mathématiques

The tools of dynamical systems theory are having an increasing impact on our understanding of patterns of neural activity. In this talk I will describe how to build tractable tissue level models that maintain a strong link with biophysical reality. T... Read More about Mathematical neuroscience: from neurons to networks.

Unifying principles of calcium wave propagation: insights from a three-dimensional model for atrial myocytes (2015)
Journal Article
Thul, R., Rietdorf, K., Bootman, M. D., & Coombes, S. (2015). Unifying principles of calcium wave propagation: insights from a three-dimensional model for atrial myocytes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1853(9), https://doi.org/10.1016/j.bbamcr.2015.02.019

Atrial myocytes in a number of species lack transverse tubules. As a consequence the intracellular calcium signals occurring during each heartbeat exhibit complex spatio-temporal dynamics. These calcium patterns arise from saltatory calcium waves tha... Read More about Unifying principles of calcium wave propagation: insights from a three-dimensional model for atrial myocytes.