All Outputs (4)

Probabilistic encoding of stimulus strength in astrocyte global calcium signals (2015)
Journal Article
Croft, W., Reusch, K., Tilunaite, A., Russell, N. A., Thul, R., & Bellamy, T. C. (2016). Probabilistic encoding of stimulus strength in astrocyte global calcium signals. Glia, 64(4), 537-552. https://doi.org/10.1002/glia.22947

© 2016 Wiley Periodicals, Inc. Astrocyte calcium signals can range in size from subcellular microdomains to waves that spread through the whole cell (and into connected cells). The differential roles of such local or global calcium signaling are unde... Read More about Probabilistic encoding of stimulus strength in astrocyte global calcium signals.

First passage times in integrate-and-fire neurons with stochastic thresholds (2015)
Journal Article
Braun, W., Matthews, P. C., & Thul, R. (2015). First passage times in integrate-and-fire neurons with stochastic thresholds. Physical Review E, 91, Article 052701. https://doi.org/10.1103/PhysRevE.91.052701

We consider a leaky integrate--and--fire neuron with deterministic subthreshold dynamics and a firing threshold that evolves as an Ornstein-Uhlenbeck process. The formulation of this minimal model is motivated by the experimentally observed widesprea... Read More about First passage times in integrate-and-fire neurons with stochastic thresholds.

Modelling cell cycle synchronisation in networks of coupled radial glial cells (2015)
Journal Article
Barrack, D., Thul, R., & Owen, M. R. (2015). Modelling cell cycle synchronisation in networks of coupled radial glial cells. Journal of Theoretical Biology, 377, https://doi.org/10.1016/j.jtbi.2015.04.013

Radial glial cells play a crucial role in the embryonic mammalian brain. Their proliferation is thought to be controlled, in part, by ATP mediated calcium signals. It has been hypothesised that these signals act to locally synchronise cell cycles, so... Read More about Modelling cell cycle synchronisation in networks of coupled radial glial cells.

Unifying principles of calcium wave propagation: insights from a three-dimensional model for atrial myocytes (2015)
Journal Article
Thul, R., Rietdorf, K., Bootman, M. D., & Coombes, S. (2015). Unifying principles of calcium wave propagation: insights from a three-dimensional model for atrial myocytes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1853(9), https://doi.org/10.1016/j.bbamcr.2015.02.019

Atrial myocytes in a number of species lack transverse tubules. As a consequence the intracellular calcium signals occurring during each heartbeat exhibit complex spatio-temporal dynamics. These calcium patterns arise from saltatory calcium waves tha... Read More about Unifying principles of calcium wave propagation: insights from a three-dimensional model for atrial myocytes.