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All Outputs (6)

Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1 (2015)
Journal Article
Winkler, S., Jadhav, G. P., Kaur, I., Maryati, M., Airhihen, B., & Fischer, P. M. (2015). Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1. Bioorganic and Medicinal Chemistry Letters, 25(19), 4219-4224. https://doi.org/10.1016/j.bmcl.2015.07.095

Eukaryotic mRNA contains a 3? poly(A) tail, which plays important roles in the regulation of mRNA stability and translation. Well-characterized enzymes involved in the shortening of the poly(A) tail include the multi-subunit Ccr4-Not deadenylase, whi... Read More about Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1.

Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and ?(9)-tetrahydrocannabinol in rat plasma (2015)
Journal Article
Zgair, A., Wong, J., Sabri, A., Fischer, P., Barrett, D., Constantinescu, C., & Gershkovich, P. (2015). Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and ?(9)-tetrahydrocannabinol in rat plasma. Journal of Pharmaceutical and Biomedical Analysis, 114, 145-151. doi:10.1016/j.jpba.2015.05.019

Mutations in a translation initiation factor identify the target of a memory-enhancing compound (2015)
Journal Article
Sekine, Y., Zyryanova, A., Crespillo-Casado, A., Fischer, P., Harding, H. P., & Ron, D. (2015). Mutations in a translation initiation factor identify the target of a memory-enhancing compound. Science, 348(6238), 1027-1030. https://doi.org/10.1126/science.aaa6986

The integrated stress response (ISR) modulates messenger RNA translation to regulate the mammalian unfolded protein response (UPR), immunity, and memory formation. A chemical ISR inhibitor, ISRIB, enhances cognitive function and modulates the UPR in... Read More about Mutations in a translation initiation factor identify the target of a memory-enhancing compound.

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity (2015)
Journal Article
Halliday, M., Ortori, C., Radford, H., Barrett, D., Sekine, Y., Fischer, P., …Mallucci, G. (2015). Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Cell Death and Disease, 6, https://doi.org/10.1038/cddis.2015.49

© 2015 Macmillan Publishers Limited All rights reserved. Activation of the PERK branch of the unfolded protein response (UPR) in response to protein misfolding within the endoplasmic reticulum (ER) results in the transient repression of protein synth... Read More about Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity.

Coagulation factor XII protease domain crystal structure (2015)
Journal Article
Pathak, M., Wilmann, P., Awford, J., Li, C., Hamad, B., Fischer, P., …Emsley, J. (2015). Coagulation factor XII protease domain crystal structure. Journal of Thrombosis and Haemostasis, 13(4), 580-591. https://doi.org/10.1111/jth.12849

Background: Coagulation factor XII is a serine protease that is important for kinin generation and blood coagulation, cleaving the substrates plasma kallikrein and FXI. Objective: To investigate FXII zymogen activation and substrate recognition by d... Read More about Coagulation factor XII protease domain crystal structure.