All Outputs (2)

An internal ribosome entry site in the 5? untranslated region of epidermal growth factor receptor allows hypoxic expression (2015)
Journal Article
Webb, T. E., Hughes, A., Smalley, D., & Spriggs, K. (in press). An internal ribosome entry site in the 5? untranslated region of epidermal growth factor receptor allows hypoxic expression. Oncogenesis, 4, Article e134. https://doi.org/10.1038/oncsis.2014.43

The expression of epidermal growth factor receptor (EGFR/ERBB1/HER1) is implicated in the progress of numerous cancers, a feature that has been exploited in the development of EGFR antibodies and EGFR tyrosine kinase inhibitors as anti-cancer drugs.... Read More about An internal ribosome entry site in the 5? untranslated region of epidermal growth factor receptor allows hypoxic expression.

The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape (2015)
Journal Article
Modelska, A., Turro, E., Russell, R., Beaton, J., Sbarrato, T., Spriggs, K., …Le Quesne, J. (2015). The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape. Cell Death and Disease, 6, Article e1603. https://doi.org/10.1038/cddis.2014.542

Human mRNA DeXD/H-box helicases are ubiquitous molecular motors that are required for the majority of cellular processes that involve RNA metabolism. One of the most abundant is eIF4A, which is required during the initiation phase of protein synthesi... Read More about The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.