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Early structural remodeling and deuterium oxide-derived protein metabolic responses to eccentric and concentric loading in human skeletal muscle (2015)
Journal Article
Franchi, M. V., Wilkinson, D. J., Quinlan, J. I., Mitchell, W. K., Lund, J. N., Williams, J. P., …Narici, M. V. (2015). Early structural remodeling and deuterium oxide-derived protein metabolic responses to eccentric and concentric loading in human skeletal muscle. Physiological Reports, 3(11), Article e12593. https://doi.org/10.14814/phy2.12593

We recently reported that the greatest distinguishing feature between eccentric (ECC) and concentric (CON) muscle loading lays in architectural adaptations: ECC favors increases in fascicle length (Lf), associated with distal vastus lateralis muscle... Read More about Early structural remodeling and deuterium oxide-derived protein metabolic responses to eccentric and concentric loading in human skeletal muscle.

Preventive acetaminophen reduces postoperative opioid consumption, vomiting, and pain scores after surgery: systematic review and meta-analysis (2015)
Journal Article
Doleman, B., Read, D., Lund, J. N., & Williams, J. P. (2015). Preventive acetaminophen reduces postoperative opioid consumption, vomiting, and pain scores after surgery: systematic review and meta-analysis. Regional Anesthesia and Pain Medicine, 40(6), https://doi.org/10.1097/AAP.0000000000000311

Background and Objectives: Preventive analgesia has been proposed as a potential strategy to reduce postoperative pain. However, there is currently no review that focuses on acetaminophen for preventive analgesia. Methods: We conducted a search of... Read More about Preventive acetaminophen reduces postoperative opioid consumption, vomiting, and pain scores after surgery: systematic review and meta-analysis.

The bowel cancer awareness campaign ‘Be Clear on Cancer’: sustained increased pressure on resources and over-accessed by higher social grades with no increase in cancer detected (2015)
Journal Article
Hall, S., Peacock, J. D. H., Cochrane, L. A., Peacock, O., Tierney, G. M., Tou, S. I. H., & Lund, J. (2016). The bowel cancer awareness campaign ‘Be Clear on Cancer’: sustained increased pressure on resources and over-accessed by higher social grades with no increase in cancer detected. Colorectal Disease, 18(2), 195-199. https://doi.org/10.1111/codi.13107

AIM: To evaluate the impact of the national 'Be Clear on Cancer' bowel cancer reminder campaign on service and diagnosis at a single UK institution. Secondly, to evaluate the socio-economic background of patients referred before and after the remind... Read More about The bowel cancer awareness campaign ‘Be Clear on Cancer’: sustained increased pressure on resources and over-accessed by higher social grades with no increase in cancer detected.

A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain (2015)
Journal Article
Doleman, B., Heinink, T., Faleiro, R., Lund, J. N., & Williams, J. P. (2015). A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. Anaesthesia, 70(10), https://doi.org/10.1111/anae.13179

We searched MEDLINE, Embase, CINAHL, AMED and CENTRAL databases until December 2014 and included 133 randomised controlled trials of peri-operative gabapentin vs placebo. Gabapentin reduced mean (95% CI) 24-h morphine-equivalent consumption by 8.44 (... Read More about A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain.

Day-case closure of ileostomy: feasible, safe and efficient (2015)
Journal Article
Bhalla, A., Peacock, O., Tierney, G., Tou, S., Hurst, N., Speake, W., …Lund, J. N. (2015). Day-case closure of ileostomy: feasible, safe and efficient. Colorectal Disease, 17(9), https://doi.org/10.1111/codi.12961

Aim Over 5000 loop ileostomy closures were performed in the UK in 2013 with a median inpatient stay of 5 days. Previously we have successfully implemented a 23-h protocol for loop ileostomy closure which was modified for same-day discharge. We pre... Read More about Day-case closure of ileostomy: feasible, safe and efficient.

Internal comparison between deuterium oxide (D2O) and L-[ring-13C6] phenylalanine for acute measurement of muscle protein synthesis in humans (2015)
Journal Article
Smith, K., Cegielski, J., Wilkinson, D., Phillips, B., Boereboom, C., Lund, J., & Atherton, P. (2015). Internal comparison between deuterium oxide (D2O) and L-[ring-13C6] phenylalanine for acute measurement of muscle protein synthesis in humans. Physiological Reports, 3(7), https://doi.org/10.14814/phy2.12433

Stable isotope tracer methodologies are becoming increasingly widespread in metabolic research; yet a number of factors restrict their implementation, such as, i.v infusions, multiple cannulae, tissue samples, and significant cost. We recently valida... Read More about Internal comparison between deuterium oxide (D2O) and L-[ring-13C6] phenylalanine for acute measurement of muscle protein synthesis in humans.

Creatinine and myoglobin are poor predictors of anaerobic threshold in colorectal cancer and health (2015)
Journal Article
Nyasavajjala, S. M., Phillips, B. E., Lund, J. N., & Williams, J. P. (2015). Creatinine and myoglobin are poor predictors of anaerobic threshold in colorectal cancer and health. Journal of Cachexia, Sarcopenia and Muscle, 6(2), https://doi.org/10.1002/jcsm.12020

Aims Myoglobin is a haem protein produced in skeletal muscles. Serum concentrations of myoglobin have been proposed as a surrogate marker of muscle mass and function in both cachectic cancer patients and healthy non-cancer individuals. Creatinine,... Read More about Creatinine and myoglobin are poor predictors of anaerobic threshold in colorectal cancer and health.

Assessing surgeon stress when operating using heart rate variability and the State Trait Anxiety Inventory: will surgery be the death of us? (2015)
Journal Article
Jones, K., Amawi, F., Bhalla, A., Peacock, O., Williams, J. P., & Lund, J. N. (2015). Assessing surgeon stress when operating using heart rate variability and the State Trait Anxiety Inventory: will surgery be the death of us?. Colorectal Disease, 17(4), https://doi.org/10.1111/codi.12844

Aim Performance in the operating room is affected by a combination of individual, patient and environmental factors amongst others. Stress has a potential negative impact on performance with the quality of surgical practice and patient safety bein... Read More about Assessing surgeon stress when operating using heart rate variability and the State Trait Anxiety Inventory: will surgery be the death of us?.

Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling (2015)
Journal Article
Brook, M. S., Wilkinson, D. J., Mitchell, W. K., Lund, J. N., Szewczyk, N. J., Greenhaff, P. L., …Atherton, P. (2015). Skeletal muscle hypertrophy adaptations predominate in the early stages of resistance exercise training, matching deuterium oxide-derived measures of muscle protein synthesis and mechanistic target of rapamycin complex 1 signaling. FASEB Journal, 29(11), https://doi.org/10.1096/fj.15-273755