3D printing of tablets containing multiple drugs with defined release profiles
(2015)
Journal Article
Khaled, S., Burley, J., Alexander, M., Yang, J., & Roberts, C. (2015). 3D printing of tablets containing multiple drugs with defined release profiles. International Journal of Pharmaceutics, 494(2), 643-650. doi:10.1016/j.ijpharm.2015.07.067
All Outputs (6)
3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles (2015)
Journal Article
Khaled, S. A., Burley, J. C., Alexander, M. R., Yang, J., & Roberts, C. J. (in press). 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. Journal of Controlled Release, 217, https://doi.org/10.1016/j.jconrel.2015.09.028We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypil... Read More about 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles.
Investigating the dissolution performance of amorphous solid dispersions using magnetic resonance imaging and proton NMR (2015)
Journal Article
Tres, F., Coombes, S. R., Phillips, A. R., Hughes, L. P., Wren, S. A., Aylott, J., & Burley, J. (2015). Investigating the dissolution performance of amorphous solid dispersions using magnetic resonance imaging and proton NMR. Molecules, 20(9), 16404-16418. https://doi.org/10.3390/molecules200916404
Insights into the influence of the cooling profile on the reconstitution times of amorphous lyophilized protein formulations (2015)
Journal Article
Beech, K. E., Biddlecombe, J. G., van der Walle, C. F., Stevens, L. A., Rigby, S. P., Burley, J. C., …Allena, S. (2015). Insights into the influence of the cooling profile on the reconstitution times of amorphous lyophilized protein formulations. European Journal of Pharmaceutics and Biopharmaceutics, 96, 247-254. https://doi.org/10.1016/j.ejpb.2015.07.029Lyophilized protein formulations must be reconstituted back into solution prior to patient administration and in this regard long reconstitution times are not ideal. The factors that govern reconstitution time remain poorly understood. The aim of thi... Read More about Insights into the influence of the cooling profile on the reconstitution times of amorphous lyophilized protein formulations.
The influence of polymer content on early gel-layer formation in HPMC matrices: the use of CLSM visualisation to identify the percolation threshold (2015)
Journal Article
Mason, L., Campiñez, M. D., Pygall, S. R., BURLEY, J., Gupta, P., Storey, D. E., …Melia, C. (2015). The influence of polymer content on early gel-layer formation in HPMC matrices: the use of CLSM visualisation to identify the percolation threshold. European Journal of Pharmaceutics and Biopharmaceutics, 94, 485-492. https://doi.org/10.1016/j.ejpb.2015.06.019
Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping (2015)
Journal Article
Tres, F., Aylott, J., Patient, J. D., Williams, P. M., Treacher, K., Booth, J., …Burley, J. C. (2015). Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping. Molecular Pharmaceutics, 12(5), 1512–1522. https://doi.org/10.1021/mp500829vReal-time in situ Raman mapping has been employed to monitor, during dissolution, the crystallization transitions of amorphous bicalutamide formulated as a molecular dispersion in a copovidone VA64 matrix. The dissolution performance was also investi... Read More about Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping.