Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping

Tres, Francesco; Aylott, Jonathan; Patient, Jamie D.; Williams, Philip M.; Treacher, Kevin; Booth, Jonathan; Hughes, Leslie P.; Wren, Stephen A.C.; Burley, Jonathan C.

doi:10.1021/mp500829v

All Outputs (6)

Investigating NF-kappa B signaling in lung fibroblasts in 2D and 3D culture systems (2015)
Journal Article
Su Htwe, S., Harrington, H., Knox, A., Rose, F., Aylott, J., Haycock, J. W., & Ghaemmaghami, A. M. (2015). Investigating NF-kappa B signaling in lung fibroblasts in 2D and 3D culture systems. Respiratory Research, 16, 1-9. https://doi.org/10.1186/s12931-015-0302-7

Controlled intracellular generation of reactive oxygen species in human mesenchymal stem cells using porphyrin conjugated nanoparticles (2015)
Journal Article
Lavado, A. S., Chauhan, V. M., Alhaj Zen, A., Giuntini, F., Jones, D. R. E., Boyle, R. W., …Aylott, J. W. (2015). Controlled intracellular generation of reactive oxygen species in human mesenchymal stem cells using porphyrin conjugated nanoparticles. Nanoscale, 7(34), https://doi.org/10.1039/c5nr00795j

Nanoparticles capable of generating controlled amounts of intracellular reactive oxygen species (ROS), that advance the study of oxidative stress and cellular communication, were synthesized by functionalizing polyacrylamide nanoparticles with zinc(I... Read More about Controlled intracellular generation of reactive oxygen species in human mesenchymal stem cells using porphyrin conjugated nanoparticles.

Investigating the dissolution performance of amorphous solid dispersions using magnetic resonance imaging and proton NMR (2015)
Journal Article
Tres, F., Coombes, S. R., Phillips, A. R., Hughes, L. P., Wren, S. A., Aylott, J., & Burley, J. (2015). Investigating the dissolution performance of amorphous solid dispersions using magnetic resonance imaging and proton NMR. Molecules, 20(9), 16404-16418. https://doi.org/10.3390/molecules200916404

Facile approach to generating polymeric nanoarrays containing populations of nanoparticles (2015)
Journal Article
Marques, L., Chen, X., Roberts, C. J., Clark, M., & Aylott, J. W. (2015). Facile approach to generating polymeric nanoarrays containing populations of nanoparticles. Micro and Nano Letters, 10(8), 378-383. doi:10.1049/mnl.2015.0041

The production of nanoarrays containing a population of entrapped, heterogeneous nanoparticles is reported. The nanoarray consists of a nanoporous film with pores of diameter 60-180 nm, formed from the phase separation of two immiscible polymers: pol... Read More about Facile approach to generating polymeric nanoarrays containing populations of nanoparticles.

Adapting the electrospinning process to provide three unique environments for a tri-layered in vitro model of the airway wall (2015)
Journal Article
Bridge, J. C., Aylott, J. W., Brightling, C. E., Ghaemmaghami, A. M., Knox, A. J., Lewis, M. P., …Morris, G. E. (2015). Adapting the electrospinning process to provide three unique environments for a tri-layered in vitro model of the airway wall. Journal of Visualized Experiments, 101, Article e52986. https://doi.org/10.3791/52986

Electrospinning is a highly adaptable method producing porous 3D fibrous scaffolds that can be exploited in in vitro cell culture. Alterations to intrinsic parameters within the process allow a high degree of control over scaffold characteristics inc... Read More about Adapting the electrospinning process to provide three unique environments for a tri-layered in vitro model of the airway wall.

Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping (2015)
Journal Article
Tres, F., Aylott, J., Patient, J. D., Williams, P. M., Treacher, K., Booth, J., …Burley, J. C. (2015). Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping. Molecular Pharmaceutics, 12(5), 1512–1522. https://doi.org/10.1021/mp500829v

Real-time in situ Raman mapping has been employed to monitor, during dissolution, the crystallization transitions of amorphous bicalutamide formulated as a molecular dispersion in a copovidone VA64 matrix. The dissolution performance was also investi... Read More about Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping.