Characterisation of human saliva as a platform for oral dissolution medium development

Gittings, Sally; Turnbull, Neil; Henry, Brian; Roberts, Clive J.; Gershkovich, Pavel

doi:10.1016/j.ejpb.2015.01.007

All Outputs (9)

Study of the effect of dipole interactions on hyperthermia heating the cluster composed of superparamagnetic nanoparticles (2015)
Journal Article
Fu, R., Yan, Y., & Roberts, C. (2015). Study of the effect of dipole interactions on hyperthermia heating the cluster composed of superparamagnetic nanoparticles. AIP Advances, 5(12), https://doi.org/10.1063/1.4939514

3D printing of tablets containing multiple drugs with defined release profiles (2015)
Journal Article
Khaled, S., Burley, J., Alexander, M., Yang, J., & Roberts, C. (2015). 3D printing of tablets containing multiple drugs with defined release profiles. International Journal of Pharmaceutics, 494(2), 643-650. doi:10.1016/j.ijpharm.2015.07.067

3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles (2015)
Journal Article
Khaled, S. A., Burley, J. C., Alexander, M. R., Yang, J., & Roberts, C. J. (in press). 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles. Journal of Controlled Release, 217, https://doi.org/10.1016/j.jconrel.2015.09.028

We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypil... Read More about 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles.

Facile approach to generating polymeric nanoarrays containing populations of nanoparticles (2015)
Journal Article
Marques, L., Chen, X., Roberts, C. J., Clark, M., & Aylott, J. W. (2015). Facile approach to generating polymeric nanoarrays containing populations of nanoparticles. Micro and Nano Letters, 10(8), 378-383. doi:10.1049/mnl.2015.0041

The production of nanoarrays containing a population of entrapped, heterogeneous nanoparticles is reported. The nanoarray consists of a nanoporous film with pores of diameter 60-180 nm, formed from the phase separation of two immiscible polymers: pol... Read More about Facile approach to generating polymeric nanoarrays containing populations of nanoparticles.

Long-term amorphous drug stability predictions using easily calculated, predicted, and measured parameters (2015)
Journal Article
Nurzy?ska, K., Booth, J., Roberts, C., McCabe, J., Dryden, I., & Fischer, P. M. (2015). Long-term amorphous drug stability predictions using easily calculated, predicted, and measured parameters. Molecular Pharmaceutics, 12(9), 3389-3398. doi:10.1021/acs.molpharmaceut.5b00409

Electrospray deposition in vacuum as method to create functionally active protein immobilization on polymeric substrates (2015)
Journal Article
Fornari, E., Roberts, C. J., Temperton, R. H., & O’Shea, J. N. (2015). Electrospray deposition in vacuum as method to create functionally active protein immobilization on polymeric substrates. Journal of Colloid and Interface Science, 453, 252-259. https://doi.org/10.1016/j.jcis.2015.05.007

We demonstrate in this work the deposition of a large biological molecule (fibronectin) on polymeric substrates in a high vacuum environment using an electrospray deposition system. Fibronectin was deposited and its distribution and structure investi... Read More about Electrospray deposition in vacuum as method to create functionally active protein immobilization on polymeric substrates.

The Influence of Spray-Drying Parameters on Phase Behavior, Drug Distribution, and In Vitro Release of Injectable Microspheres for Sustained Release (2015)
Journal Article
Roberts, C., Meeus, J., Lenaerts, M., Scurr, D. J., Amssoms, K., Davies, M. C., & Van den mooter, G. (2015). The Influence of Spray-Drying Parameters on Phase Behavior, Drug Distribution, and In Vitro Release of Injectable Microspheres for Sustained Release. Journal of Pharmaceutical Sciences, 104(4), 1451-1460. doi:10.1002/jps.24361

Analysis of leaf surfaces using scanning ion conductance microscopy (2015)
Journal Article
Walker, S. C., Allen, S., Bell, G., & Roberts, C. J. (2015). Analysis of leaf surfaces using scanning ion conductance microscopy. Journal of Microscopy, 258(2), https://doi.org/10.1111/jmi.12225

Leaf surfaces are highly complex functional systems with well defined chemistry and structure dictating the barrier and transport properties of the leaf cuticle. It is a significant imaging challenge to analyse the very thin and often complex wax-lik... Read More about Analysis of leaf surfaces using scanning ion conductance microscopy.

Characterisation of human saliva as a platform for oral dissolution medium development (2015)
Journal Article
Gittings, S., Turnbull, N., Henry, B., Roberts, C. J., & Gershkovich, P. (2015). Characterisation of human saliva as a platform for oral dissolution medium development. European Journal of Pharmaceutics and Biopharmaceutics, 91, 16-24. https://doi.org/10.1016/j.ejpb.2015.01.007

Human saliva is a biological fluid of great importance in the field of dissolution testing. However, until now, no consensus has been reached on its key characteristics relevant to dissolution testing. As a result, it is difficult to select or develo... Read More about Characterisation of human saliva as a platform for oral dissolution medium development.