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Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters (2015)
Journal Article
Samms, R. J., Lewis, J. E., Lory, A., Fowler, M. J., Cooper, S., Warner, A., …Ebling, F. J. (2015). Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters. Current Biology, 25(22), https://doi.org/10.1016/j.cub.2015.10.010

Hypothalamic tanycytes are considered to function as sensors of peripheral metabolism [1]. To facilitate this role, they express a wide range of receptors, including fibroblast growth factor receptor 1 (FGFR1). Using a monoclonal antibody (IMC-H7) th... Read More about Antibody-mediated inhibition of the FGFR1c isoform induces a catabolic lean state in Siberian hamsters.

Measurement of gastric meal and secretion volumes using magnetic resonance imaging (2015)
Journal Article
Hoad, C., Parker, H., Hudders, N., Costigan, C., Cox, E., Perkins, A., …Gowland, P. (2015). Measurement of gastric meal and secretion volumes using magnetic resonance imaging. Physics in Medicine and Biology, 60(3), 1367-1383. https://doi.org/10.1088/0031-9155/60/3/1367

MRI can assess multiple gastric functions without ionizing radiation. However, time consuming image acquisition and analysis of gastric volume data, plus confounding of gastric emptying measurements by gastric secretions mixed with the test meal have... Read More about Measurement of gastric meal and secretion volumes using magnetic resonance imaging.