All Outputs (2769)

Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer (2014)
Journal Article
Davis, J., Martin, S. G., Patel, P. M., Green, A. R., Rakha, E. A., Ellis, I. O., & Storr, S. J. (2014). Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer. BMC Cancer, 14(1), https://doi.org/10.1186/1471-2407-14-995

Background The calpains are intracellular cysteine proteases that function in a variety of important cellular functions, including signalling, motility, apoptosis and survival. In breast cancer high calpain-1 and calpain-2 expression has been asso... Read More about Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer.

"This world of inarticulate power": J.M. Synge's Riders to the Sea and magical realism (2014)
Book Chapter
Collins, C. (2014). "This world of inarticulate power": J.M. Synge's Riders to the Sea and magical realism. In J. F. Dean, & J. Lanters (Eds.), Beyond realism: experimental and unconventional Irish drama since the revival (13-27). Rodopi. https://doi.org/10.1163/9789401212014_003

Simple psoas cross-sectional area measurement is a quick and easy method to assess sarcopenia and predicts major surgical complications (2014)
Journal Article
Jones, K., Doleman, B., Scott, S., Lund, J. N., & Williams, J. P. (2015). Simple psoas cross-sectional area measurement is a quick and easy method to assess sarcopenia and predicts major surgical complications. Colorectal Disease, 17(1), Article O20-O26. https://doi.org/10.1111/codi.12805

Aim Radiologically assessed muscle mass has been suggested as a surrogate marker of functional status and frailty and may predict patients at risk of postoperative complications. We hypothesize that sarcopenia negatively impacts on postoperative r... Read More about Simple psoas cross-sectional area measurement is a quick and easy method to assess sarcopenia and predicts major surgical complications.

Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor (2014)
Journal Article
Wall, R. J., Fernades, A., Rose, M., Bell, D. R., & Mellor, I. R. (2015). Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor. Environment International, 76, 49-56. https://doi.org/10.1016/j.envint.2014.12.002

The Aryl hydrocarbon receptor (AhR) binds a variety of chlorinated and brominated dioxins, furans and biphenyls. Mixed halogenated variants have been recently identified in food at significant levels but full characterisation requires potency data in... Read More about Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor.

From publics to practitioners: invention power and open technoscience (2014)
Journal Article
Papadopoulos, D. (2015). From publics to practitioners: invention power and open technoscience. Science as Culture, 24(1), (108-121). doi:10.1080/09505431.2014.986322. ISSN 0950-5431

There are more publics involved in science than one would imagine at first sight. In technoscientific conditions what counts as knowledge creation is not primarily the individual experimental achievement that gives coherence to scientific practice an... Read More about From publics to practitioners: invention power and open technoscience.

The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles (2014)
Journal Article
Redshaw, Z., Sweetman, D., & Loughna, P. (in press). The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles. Differentiation, 88(4-5), https://doi.org/10.1016/j.diff.2014.12.001

Aging is associated with a gradual loss of skeletal muscle mass and an impaired ability of this tissue to compensate for trauma. Studies in rodents and humans have also shown that resident stem cells within muscle have a reduced ability to proliferat... Read More about The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles.

Jómsvíkinga Sǫgur and Jómsvíkinga Drápur: texts, contexts and intertexts (2014)
Journal Article
Jesch, J. (2014). Jómsvíkinga Sǫgur and Jómsvíkinga Drápur: texts, contexts and intertexts. Scripta Islandica, 65, 81-100

Using theories of intertextuality the paper explores the implications of the complex transmission of Jómsvíkinga saga, with its multiple manuscripts, versions and cross-references in other texts. It then concentrates on the story-complex about the Jó... Read More about Jómsvíkinga Sǫgur and Jómsvíkinga Drápur: texts, contexts and intertexts.

Parallels, prescience and the past: analogical reasoning and contemporary international politics (2014)
Journal Article
Mumford, A. (2015). Parallels, prescience and the past: analogical reasoning and contemporary international politics. International Politics, 52(1), https://doi.org/10.1057/ip.2014.40

Analogical reasoning has held a perpetual appeal to policymakers who have often drafted in historical metaphor as a mode of informing decision-making. However, this article contends that since the beginning of the ‘War on Terror’ we have arguably see... Read More about Parallels, prescience and the past: analogical reasoning and contemporary international politics.

Viewing Animal Models for Tuberous Sclerosis Complex in the Light of Evolution (2014)
Book Chapter
Howe, C. J., Serfontein, J., Nisbet, R. E. R., & de Vries, P. J. (2015). Viewing Animal Models for Tuberous Sclerosis Complex in the Light of Evolution. In Organism Models of Autism Spectrum Disorders. , (99-115). Springer New York. https://doi.org/10.1007/978-1-4939-2250-5_4

Tuberous sclerosis complex (TSC) is a multisystem disorder usually caused by a mutation in either the TSC1 or TSC2 genes. Approximately 50 % of individuals with TSC develop an autism spectrum disorder. Between 1 and 4 % of autism is attributable to t... Read More about Viewing Animal Models for Tuberous Sclerosis Complex in the Light of Evolution.

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1? degradation (2014)
Journal Article
Melino, G., Amelio, I., Mak, T. W., Inoue, S., Knight, R. A., Markert, E. K., & Levine, A. J. (2015). TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1? degradation. Proceedings of the National Academy of Sciences, 112(1), 226-231. https://doi.org/10.1073/pnas.1410609111

Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activation are associated with cancer progression. Here, we demonstrate that the transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus affecting tumor angio... Read More about TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1? degradation.

Detection and quantification of allosteric modulation of endogenous M4 muscarinic acetylcholine receptor using impedance-based label-free technology in a neuronal cell line (2014)
Journal Article
Chen, A. N., Chen, A., Malone, D. T., Pabreja, K., Sexton, P. M., Christopoulos, A., & Canals, M. (2014). Detection and quantification of allosteric modulation of endogenous M4 muscarinic acetylcholine receptor using impedance-based label-free technology in a neuronal cell line. Journal of Biomolecular Screening, 20(5), 646-654. https://doi.org/10.1177/1087057114563025

© 2014 Society for Laboratory Automation and Screening. Allosteric modulators of G protein-coupled receptors have the potential to achieve greater receptor subtype selectivity compared with ligands targeting the orthosteric site of this receptor fami... Read More about Detection and quantification of allosteric modulation of endogenous M4 muscarinic acetylcholine receptor using impedance-based label-free technology in a neuronal cell line.

High-grade encapsulated papillary carcinoma of the breast: an under-recognized entity (2014)
Journal Article
Rakha, E. A., Varga, Z., Elsheik, S., & Ellis, I. O. (2015). High-grade encapsulated papillary carcinoma of the breast: an under-recognized entity. Histopathology, 66(5), 740-746. doi:10.1111/his.12591

Aims Encapsulated papillary carcinoma (EPC) is a recognized special type of breast carcinoma. Despite compelling evidence indicating its invasive nature, although not of a conventional form, the current consensus is to manage EPC as an in?situ disea... Read More about High-grade encapsulated papillary carcinoma of the breast: an under-recognized entity.

Priming memories of past wins induces risk seeking (2014)
Journal Article
Ludvig, E. A., Madan, C. R., & Spetch, M. L. (2014). Priming memories of past wins induces risk seeking. Journal of Experimental Psychology: General, 144(1), 24-29. doi:10.1037/xge0000046

People are often risk averse when making decisions under uncertainty. When those decisions are based on past experience, people necessarily rely on their memories. Thus, what is remembered at the time of the choice should influence risky choice. We t... Read More about Priming memories of past wins induces risk seeking.

Patterns of genome evolution that have accompanied host adaptation in Salmonella (2014)
Journal Article
Langridge, G. C., Fookes, M., Connor, T. R., Feltwell, T., Feasey, N., Parsons, B. N., …Thomson, N. R. (2015). Patterns of genome evolution that have accompanied host adaptation in Salmonella. Proceedings of the National Academy of Sciences, 112(3), 863-868. https://doi.org/10.1073/pnas.1416707112

Many bacterial pathogens are specialized, infecting one or few hosts, and this is often associated with more acute disease presentation. Specific genomes show markers of this specialization, which often reflect a balance between gene acquisition and... Read More about Patterns of genome evolution that have accompanied host adaptation in Salmonella.

Spatial complementarity and the coexistence of species (2014)
Journal Article
Velázquez, J., Garrahan, J. P., & Eichhorn, M. P. (2014). Spatial complementarity and the coexistence of species. PLoS ONE, 9(12), Article e114979. https://doi.org/10.1371/journal.pone.0114979

© 2014 Velázquez et al. Coexistence of apparently similar species remains an enduring paradox in ecology. Spatial structure has been predicted to enable coexistence even when population-level models predict competitive exclusion if it causes each spe... Read More about Spatial complementarity and the coexistence of species.

Impedance sensitive STATCOM control for systems supported by renewable generation (2014)
Conference Proceeding
Rose, C. J., Sumner, M., Thomas, D. W., & Christopher, E. (in press). Impedance sensitive STATCOM control for systems supported by renewable generation.

Reactive power control is known to be an effective means of controlling voltage; however, for optimal performance, the system reactance must be known. Power systems with high re-newable energy penetration have been known to have voltage stability iss... Read More about Impedance sensitive STATCOM control for systems supported by renewable generation.

Calculation of the vibrational frequencies of carbon clusters and fullerenes with empirical potentials (2014)
Journal Article
Do, H., & Besley, N. A. (2014). Calculation of the vibrational frequencies of carbon clusters and fullerenes with empirical potentials. Physical Chemistry Chemical Physics, 17(5), 3898-3908. https://doi.org/10.1039/c4cp05424e

© the Owner Societies 2015. Vibrational frequencies for carbon clusters, fullerenes and nanotubes evaluated using empirical carbon-carbon potentials are presented. For linear and cyclic clusters, frequencies evaluated with the reactive empirical bond... Read More about Calculation of the vibrational frequencies of carbon clusters and fullerenes with empirical potentials.

Biological and clinical significance of PARP1 protein expression in breast cancer (2014)
Journal Article
Green, A. R., Caracappa, D., Benhasouna, A. A., Alshareeda, A., Nolan, C. C., Macmillan, R. D., …Rakha, E. A. (2015). Biological and clinical significance of PARP1 protein expression in breast cancer. Breast Cancer Research and Treatment, 149(2), 353-362. https://doi.org/10.1007/s10549-014-3230-1

Poly(ADP-ribose) polymerase-1 (PARP1) is a key facilitator of DNA repair. PARP inhibitors have gained recent attention as promising therapeutic agents for the treatment of solid tumours including breast cancer (BC). However, the biological and clinic... Read More about Biological and clinical significance of PARP1 protein expression in breast cancer.

Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases (2014)
Journal Article
Jenner, M., Afonso, J. P., Bailey, H. R., Frank, S., Kampa, A., Piel, J., & Oldfield, N. J. (2015). Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases. Angewandte Chemie International Edition, 54(6), https://doi.org/10.1002/anie.201410219

Type I modular polyketide synthases (PKSs), responsible for the biosynthesis of many biologically active agents, possess a ketosynthase (KS) domain within each module to catalyze chain elongation. Acylation of the KS active site Cys residue is foll... Read More about Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases.

Convergent genetic and expression data implicate immunity in Alzheimer's disease (2014)
Journal Article
Bossù, P., Tsuang, D. W., Lleò, A., Wallon, D., Todd, S., Dufouil, C., …Holmans, P. (2015). Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's and Dementia, 11(6), 658-671. https://doi.org/10.1016/j.jalz.2014.05.1757

© 2015, Elsevier Inc. All rights reserved. Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underly... Read More about Convergent genetic and expression data implicate immunity in Alzheimer's disease.