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All Outputs (42)

The current provision of community-based teaching in UK medical schools: an online survey and systematic review (2014)
Journal Article
Lee, S. W., Clement, N., Tang, N., & Atiomo, W. (2014). The current provision of community-based teaching in UK medical schools: an online survey and systematic review. BMJ Open, 4, Article e005696. https://doi.org/10.1136/bmjopen-2014-005696

Objective: To evaluate the current provision and outcome of community-based education (CBE) in UK medical schools. Design and data sources: An online survey of UK medical school websites and course prospectuses and a systematic review of articles f... Read More about The current provision of community-based teaching in UK medical schools: an online survey and systematic review.

Prophylactic anti-staphylococcal antibiotics for cystic fibrosis (2014)
Journal Article
Smyth, A. R., & Walters, S. (2014). Prophylactic anti-staphylococcal antibiotics for cystic fibrosis. Cochrane Library, Article CD001912. https://doi.org/10.1002/14651858.CD001912.pub3

Background Staphylococcus aureus causes pulmonary infection in young children with cystic fibrosis. Prophylactic antibiotics are prescribed hoping to prevent such infection and lung damage. Antibiotics have adverse effects and long-term use might le... Read More about Prophylactic anti-staphylococcal antibiotics for cystic fibrosis.

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2014)
Journal Article
Langton Hewer, S. C., & Smyth, A. R. (2014). Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis. Cochrane Library, https://doi.org/10.1002/14651858.CD004197.pub4

Background: Respiratory tract infection with Pseudomonas aeruginosa occurs inmost people with cystic fibrosis. Once chronic infection is established, Pseudomonas aeruginosa is virtually impossible to eradicate and is associated with increased mortali... Read More about Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis.

Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia (2014)
Journal Article
Mistry, H. D., Gill, C., Kurlak, L., Seed, P. T., Hestketh, J., Meplan, C., …Poston, L. (2015). Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia. Free Radical Biology and Medicine, 78, https://doi.org/10.1016/j.freeradbiomed.2014.10.580

Aims: Pre-eclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Deficiencies of specific micronutrient antioxidant activities associated with copper, selenium, zinc... Read More about Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia.

Maternal endocrine adaptation throughout pregnancy to nutrient manipulation: Consequences for sexually dimorphic programming of thyroid hormones and development of their progeny (2014)
Journal Article
Micke, G., Sullivan, T., Kennaway, D., Hernandez-Medrano, J., & Perry, V. (2015). Maternal endocrine adaptation throughout pregnancy to nutrient manipulation: Consequences for sexually dimorphic programming of thyroid hormones and development of their progeny. Theriogenology, 83(4), 604-615. https://doi.org/10.1016/j.theriogenology.2014.10.022

Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration (2014)
Journal Article
Khan, G. H., Galazis, N., Docheva, N., Layfield, R., & Atiomo, W. (2014). Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration. Human Reproduction, 30(1), https://doi.org/10.1093/humrep/deu268

Study question: Do any proteomic biomarkers previously identified for pre-eclampsia (PE) overlap with those identified in women with polycystic ovary syndrome (PCOS). Summary answer: Five previously identified proteomic biomarkers were found to be c... Read More about Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration.

Long-term virological outcome in children on antiretroviral therapy in the UK and Ireland (2014)
Journal Article
Duong, T., Judd, A., Collins, I. J., Doerholt, K., Lyall, H., Foster, C., …Smyth, A. R. (2014). Long-term virological outcome in children on antiretroviral therapy in the UK and Ireland. AIDS, 28(16), https://doi.org/10.1097/QAD.0000000000000438

Objective: To assess factors at the start of antiretroviral therapy (ART) associated with long-term virological response in children. Design: Multicentre national cohort. Methods: Factors associated with viral load below 400 copies/ml by 12 months... Read More about Long-term virological outcome in children on antiretroviral therapy in the UK and Ireland.

Efficacy of dehydroepiandrosterone to overcome the effect of ovarian ageing (DITTO): a proof of principle randomised controlled trial protocol (2014)
Journal Article
Jayaprakasan, K., Narkwichean, A., Maalouf, W. E., & Campbell, B. K. (2014). Efficacy of dehydroepiandrosterone to overcome the effect of ovarian ageing (DITTO): a proof of principle randomised controlled trial protocol. BMJ Open, 4(10), Article e005767. https://doi.org/10.1136/bmjopen-2014-005767

Introduction: Dehydroepiandrosterone (DHEA) has been proposed to improve pregnancy rates in women with diminished ovarian reserve undergoing in vitro fertilisation (IVF) treatment. However, evidence regarding its efficacy is supported by a limited n... Read More about Efficacy of dehydroepiandrosterone to overcome the effect of ovarian ageing (DITTO): a proof of principle randomised controlled trial protocol.

Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma (2014)
Journal Article
Smith, S. J., Rahman, C. V., Ritchie, A. A., Gould, T. W., Ward, J. H., Shakesheff, K. M., …Clarke, P. A. (2014). Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma. Annals of The Royal College of Surgeons of England, 96(7), 495-501. https://doi.org/10.1308/003588414X13946184903568

Introduction: The median survival of patients with glioblastoma multiforme (astrocytoma grade 4) remains less than 18 months despite radical surgery, radiotherapy and systemic chemotherapy. Surgical implantation of chemotherapy eluting wafers into th... Read More about Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma.

Effect of nicotine patches in pregnancy on infant and maternal outcomes at 2 years: follow-up from the randomised, double-blind, placebo-controlled SNAP trial (2014)
Journal Article
Cooper, S., Taggar, J., Lewis, S., Marlow, N., Dickinson, A., Whitemore, R., & Coleman, T. (2014). Effect of nicotine patches in pregnancy on infant and maternal outcomes at 2 years: follow-up from the randomised, double-blind, placebo-controlled SNAP trial. Lancet Respiratory Medicine, 2(9), https://doi.org/10.1016/S2213-2600%2814%2970157-2

BACKGROUND: The SNAP (Smoking and Nicotine in Pregnancy) trial compared nicotine replacement therapy (NRT) patches with placebo in pregnant smokers; although NRT doubled cessation rates in the first 4 weeks, by delivery no differences in maternal sm... Read More about Effect of nicotine patches in pregnancy on infant and maternal outcomes at 2 years: follow-up from the randomised, double-blind, placebo-controlled SNAP trial.

Evaluating the impact of the reconfiguration of gynaecology services at a University Hospital NHS trust in the United Kingdom (2014)
Journal Article
Choo, T., Deb, S., Wilkins, J., & Atiomo, W. (2014). Evaluating the impact of the reconfiguration of gynaecology services at a University Hospital NHS trust in the United Kingdom. BMC Health Services Research, 14(428), https://doi.org/10.1186/1472-6963-14-428

Background: The project aim was to investigate the impact of reconfiguring gynaecology services on the key performance indicators of a University Hospital NHS Trust in the UK. The reconfiguration involved the centralisation of elective gynaecology... Read More about Evaluating the impact of the reconfiguration of gynaecology services at a University Hospital NHS trust in the United Kingdom.

Nuclear Transfer in Ruminants (2014)
Book Chapter
Lee, J. H., & Maalouf, W. E. (2014). Nuclear Transfer in Ruminants. In N. Beaujean, H. Jammes, & A. Jouneau (Eds.), Nuclear reprogramming: methods and protocols (25-36). Springer New York. https://doi.org/10.1007/978-1-4939-1594-1_3

© Springer Science+Business Media New York 2015. Ruminants were the first mammalian species to be cloned successfully by nuclear transplantation. Those experiments were designed to multiply high merit animals (Willadsen, Nature 320(6057):63–65, 1986;... Read More about Nuclear Transfer in Ruminants.

Surgical intervention versus expectant management for endometrial polyps in subfertile women (2014)
Journal Article
Jayaprakasan, K., Polanski, L., Sahu, B., Thornton, J., & Raine-Fenning, N. (2014). Surgical intervention versus expectant management for endometrial polyps in subfertile women. Cochrane Library, https://doi.org/10.1002/14651858.CD009592.pub2

BACKGROUND: Endometrial polyps, which are benign growths of the endometrium, may be a factor in female subfertility. Possible mechanisms include physical interference with gamete transport, alteration of the endometrial milieu and unresponsiveness t... Read More about Surgical intervention versus expectant management for endometrial polyps in subfertile women.

Lipidomic analysis of plasma samples from women with polycystic ovary syndrome (2014)
Journal Article
Haoula, Z., Ravipati, S., Stekel, D. J., Ortori, C. A., Hodgman, C., Daykin, C., …Atiomo, W. (2015). Lipidomic analysis of plasma samples from women with polycystic ovary syndrome. Metabolomics, 11(3), 657-666. https://doi.org/10.1007/s11306-014-0726-y

Abstract Polycystic ovary syndrome (PCOS) is a common disorder affecting between 5 and 18 % of females of reproductive age and can be diagnosed based on a combination of clinical, ultrasound and biochemical features, none of which on its own is diagn... Read More about Lipidomic analysis of plasma samples from women with polycystic ovary syndrome.

The SNAP trial: A randomised placebo-controlled trial of nicotine replacement therapy in pregnancy - Clinical effectiveness and safety until 2 years after delivery, with economic evaluation (2014)
Journal Article
Cooper, S., Lewis, S., Thornton, J., Marlow, N., Watts, K., Britton, J., …Coleman, T. (2014). The SNAP trial: A randomised placebo-controlled trial of nicotine replacement therapy in pregnancy - Clinical effectiveness and safety until 2 years after delivery, with economic evaluation. Health Technology Assessment, 18(54), 1-128. https://doi.org/10.3310/hta18540

Background: Smoking during pregnancy causes many adverse pregnancy and birth outcomes. Nicotine replacement therapy (NRT) is effective for cessation outside pregnancy but efficacy and safety in pregnancy are unknown. We hypothesised that NRT would in... Read More about The SNAP trial: A randomised placebo-controlled trial of nicotine replacement therapy in pregnancy - Clinical effectiveness and safety until 2 years after delivery, with economic evaluation.

Feasibility and pilot study of the effects of microfinance on mortality and nutrition in children under five amongst the very poor in India: study protocol for a cluster randomized controlled trial (2014)
Journal Article
Ojha, S., Szatkowski, L., Sinha, R., Yaron, G., Fogarty, A. W., Allen, S., …Smyth, A. R. (2014). Feasibility and pilot study of the effects of microfinance on mortality and nutrition in children under five amongst the very poor in India: study protocol for a cluster randomized controlled trial. Trials, 15, Article 298. https://doi.org/10.1186/1745-6215-15-298

Background: The United Nations Millennium Development Goals include targets for the health of children under five years old. Poor health is linked to poverty and microfinance initiatives are economic interventions that may improve health by breaking... Read More about Feasibility and pilot study of the effects of microfinance on mortality and nutrition in children under five amongst the very poor in India: study protocol for a cluster randomized controlled trial.

Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era (2014)
Journal Article
Perry, C., Agarwal, D., Abdel-Fatah, T. M., Lourdusamy, A., Grundy, R., Auer, D. T., …Madhusudan, S. (2014). Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era. Oncotarget, 5(14), 5764-5781. https://doi.org/10.18632/oncotarget.2180

Deregulation of multiple DNA repair pathways may contribute to aggressive biology and therapy resistance in gliomas. We evaluated transcript levels of 157 genes involved in DNA repair in an adult glioblastoma Test set (n=191) and validated in ‘The Ca... Read More about Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era.

Prescribing practices for intravenous aminoglycosides in UK cystic fibrosis clinics: a questionnaire survey (2014)
Journal Article
Smyth, A. R., & Campbell, E. L. (2014). Prescribing practices for intravenous aminoglycosides in UK cystic fibrosis clinics: a questionnaire survey. Journal of Cystic Fibrosis, 13(4), https://doi.org/10.1016/j.jcf.2013.11.007

Background: Intravenous aminoglycoside antibiotics are widely used to treat pulmonary infection with Pseudomonas aeruginosa in individuals with cystic fibrosis (CF). Over the last decade evidence has accumulated showing that the choice of aminoglycos... Read More about Prescribing practices for intravenous aminoglycosides in UK cystic fibrosis clinics: a questionnaire survey.

Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function (2014)
Journal Article
Chen, L., Tang, W., Kowgier, M., Loth, D. W., Soler Artigas, M., Joubert, B. R., …Cassano, P. A. (2014). Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function. PLoS ONE, 9(7), Article e100776. https://doi.org/10.1371/journal.pone.0100776

Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. Methods: We performed GWAS of the rate of cha... Read More about Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function.