All Outputs (180)

Biomimetic Human Lung Models (2014)
Book Chapter
Harrington, H. C., Cato, P. A., & Ghaemmaghami, A. M. (2014). Biomimetic Human Lung Models. In Handbook of Biomimetics and Bioinspiration (1017-1036). World Scientific. https://doi.org/10.1142/9789814354936_0037

New strategies for the treatment of lung disease are being sought to combat the increased prevalence of lung disease within the developedworld.As researchmoves away from reliance upon the use of animal models in pre-clinical studies innovative method... Read More about Biomimetic Human Lung Models.

Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging (2014)
Journal Article
Harston, G. W. J., Tee, Y. K., Blockley, N., Okell, T. W., Thandeswaran, S., Shaya, G., …Kennedy, J. (2015). Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging. Brain, 138(1), 36-42. https://doi.org/10.1093/brain/awu374

© 2014 The Author. The original concept of the ischaemic penumbra suggested imaging of regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imagi... Read More about Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging.

'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models (2014)
Journal Article
Vauquelin, G., Hall, D., & Charlton, S. (2015). 'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models. British Journal of Pharmacology, 172(9), 2300-2315. https://doi.org/10.1111/bph.13053

© 2014 The British Pharmacological Society. Background and Purpose Non-competitive drugs that confer allosteric modulation of orthosteric ligand binding are of increasing interest as therapeutic agents. Sought-after advantages include a ceiling level... Read More about 'Partial' competition of heterobivalent ligand binding may be mistaken for allosteric interactions: a comparison of different target interaction models.

Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor (2014)
Journal Article
Wall, R. J., Fernades, A., Rose, M., Bell, D. R., & Mellor, I. R. (2015). Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor. Environment International, 76, 49-56. https://doi.org/10.1016/j.envint.2014.12.002

The Aryl hydrocarbon receptor (AhR) binds a variety of chlorinated and brominated dioxins, furans and biphenyls. Mixed halogenated variants have been recently identified in food at significant levels but full characterisation requires potency data in... Read More about Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor.

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1? degradation (2014)
Journal Article
Melino, G., Amelio, I., Mak, T. W., Inoue, S., Knight, R. A., Markert, E. K., & Levine, A. J. (2015). TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1? degradation. Proceedings of the National Academy of Sciences, 112(1), 226-231. https://doi.org/10.1073/pnas.1410609111

Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activation are associated with cancer progression. Here, we demonstrate that the transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus affecting tumor angio... Read More about TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1? degradation.

Spatial complementarity and the coexistence of species (2014)
Journal Article
Velázquez, J., Garrahan, J. P., & Eichhorn, M. P. (2014). Spatial complementarity and the coexistence of species. PLoS ONE, 9(12), Article e114979. https://doi.org/10.1371/journal.pone.0114979

© 2014 Velázquez et al. Coexistence of apparently similar species remains an enduring paradox in ecology. Spatial structure has been predicted to enable coexistence even when population-level models predict competitive exclusion if it causes each spe... Read More about Spatial complementarity and the coexistence of species.

Convergent genetic and expression data implicate immunity in Alzheimer's disease (2014)
Journal Article
Bossù, P., Tsuang, D. W., Lleò, A., Wallon, D., Todd, S., Dufouil, C., …Holmans, P. (2015). Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's and Dementia, 11(6), 658-671. https://doi.org/10.1016/j.jalz.2014.05.1757

© 2015, Elsevier Inc. All rights reserved. Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underly... Read More about Convergent genetic and expression data implicate immunity in Alzheimer's disease.

Contrasting patterns of turnover between plants, pollinators and their interactions (2014)
Journal Article
Norfolk, O., Eichhorn, M. P., & Gilbert, F. S. (2015). Contrasting patterns of turnover between plants, pollinators and their interactions. Diversity and Distributions, 21(4), https://doi.org/10.1111/ddi.12295

Aim: Biogeographers typically assess patterns of diversity across landscapes. As interacting groups often exhibit contrasting trends, this leads to variation in the structure of interaction networks and thereby influences ecosystem processes. Here we... Read More about Contrasting patterns of turnover between plants, pollinators and their interactions.

Dramatic potentiation of the antiviral activity of HIV antibodies by cholesterol conjugation (2014)
Journal Article
Lacek, K., Urbanowicz, R. A., Troise, F., De Lorenzo, C., Severino, V., Di Maro, A., …Pessi, A. (2014). Dramatic potentiation of the antiviral activity of HIV antibodies by cholesterol conjugation. Journal of Biological Chemistry, 289(50), 35015-35028. https://doi.org/10.1074/jbc.M114.591826

Migratory bird species benefit from traditional agricultural gardens in arid South Sinai (2014)
Journal Article
Norfolk, O., Power, A., Eichhorn, M. P., & Gilbert, F. (2015). Migratory bird species benefit from traditional agricultural gardens in arid South Sinai. Journal of Arid Environments, 114, 110-115. https://doi.org/10.1016/j.jaridenv.2014.12.004

In temperate and tropical regions agricultural conversion of natural habitat typically has negative impacts upon the diversity and functional complexity of bird communities. In arid environments however, the irrigation associated with agricultural ca... Read More about Migratory bird species benefit from traditional agricultural gardens in arid South Sinai.

Preoperative carbohydrate supplementation attenuates post-surgery insulin resistance via reduced inflammatory inhibition of the insulin-mediated restraint on muscle pyruvate dehydrogenase kinase 4 expression (2014)
Journal Article
Fosse Gjessing, P., Constantin-Teodosiu, D., Hagve, M., Lobo, D. N., Revhaug, A., & Irtun, Ø. (2015). Preoperative carbohydrate supplementation attenuates post-surgery insulin resistance via reduced inflammatory inhibition of the insulin-mediated restraint on muscle pyruvate dehydrogenase kinase 4 expression. Clinical Nutrition, 34(6), 1177-1183. https://doi.org/10.1016/j.clnu.2014.12.004

Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment (2014)
Journal Article
Füchtemeier, M., Brinckmann, M. P., Foddis, M., Kunz, A., Po, C., Curato, C., …Farr, T. D. (2015). Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment. Journal of Cerebral Blood Flow and Metabolism, 35(3), https://doi.org/10.1038/jcbfm.2014.221

Our aims were to assess the spatiotemporal development of brain pathology in a mouse model of chronic hypoperfusion using magnetic resonance imaging (MRI), and to test whether the renin-angiotensin system (RAS) can offer therapeutic benefit. For the... Read More about Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment.

Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers (2014)
Journal Article
Ebrahim, N. A., & Leach, L. (2015). Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers. Stem Cells and Development, 24(4), https://doi.org/10.1089/scd.2014.0207

Mesenchymal stem cells from Wharton’s jelly of human umbilical cords (WJ-MSC) are a valuable alternate source of stem cells. Their role in situ and whether they can interact and cross intact endothelial monolayers requires elucidation. The aim of thi... Read More about Temporal studies into attachment, VE-cadherin perturbation, and paracellular migration of human umbilical mesenchymal stem cells across umbilical vein endothelial monolayers.

Potent and efficacious inhibition of CXCR2 signaling by biparatopic nanobodies combining two distinct modes of action (2014)
Journal Article
Bradley, M. E., Dombrecht, B., Manini, J., Willis, J., Vlerick, D., De Taeye, S., …Cromie, K. D. (2015). Potent and efficacious inhibition of CXCR2 signaling by biparatopic nanobodies combining two distinct modes of action. Molecular Pharmacology, 87(2), 251-262. https://doi.org/10.1124/mol.114.094821

Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics. Chemokines and chemokine receptors are key modulators in inflammatory diseases and malignancies. Here, we describe the identification and pharmacologic character... Read More about Potent and efficacious inhibition of CXCR2 signaling by biparatopic nanobodies combining two distinct modes of action.

Bioinformatics analysis of the serine and glycine pathway in cancer cells (2014)
Journal Article
Agostini, M., Antonov, A., Morello, M., Minieri, M., Melino, G., & Amelio, I. (2014). Bioinformatics analysis of the serine and glycine pathway in cancer cells. Oncotarget, 5(22), 11004-11013. https://doi.org/10.18632/oncotarget.2668

Serine and glycine are amino acids that provide the essential precursors for the synthesis of proteins, nucleic acids and lipids. Employing 3 subsequent enzymes, phosphoglycerate dehydrogenase (PHGDH), phosphoserine phosphatase (PSPH), phosphoserine... Read More about Bioinformatics analysis of the serine and glycine pathway in cancer cells.

The population genetic structure of Biomphalaria choanomphala in Lake Victoria, East Africa: implications for schistosomiasis transmission (2014)
Journal Article
Standley, C. J., Goodacre, S. L., Wade, C. M., & Stothard, J. R. (2014). The population genetic structure of Biomphalaria choanomphala in Lake Victoria, East Africa: implications for schistosomiasis transmission. Parasites and Vectors, 7(1), Article 524. https://doi.org/10.1186/s13071-014-0524-4

Background: The freshwater snail Biomphalaria acts as the intermediate host of Schistosoma mansoni, a globally important human parasite. Understanding the population structure of intermediate host species can elucidate transmission dynamics and assis... Read More about The population genetic structure of Biomphalaria choanomphala in Lake Victoria, East Africa: implications for schistosomiasis transmission.

Fructose-1,6-bisphosphate aldolase (FBA)-A conserved glycolytic enzyme with virulence functions in bacteria: 'Ill met by moonlight' (2014)
Journal Article
Shams, F., Oldfield, N. J., Wooldridge, K. G., & Turner, D. P. J. (2014). Fructose-1,6-bisphosphate aldolase (FBA)-A conserved glycolytic enzyme with virulence functions in bacteria: 'Ill met by moonlight'. Biochemical Society Transactions, 42(6), 1792-1795. https://doi.org/10.1042/BST20140203

© 2014 Biochemical Society. Moonlighting proteins constitute an intriguing class of multifunctional proteins. Metabolic enzymes and chaperones, which are often highly conserved proteins in bacteria, archaea and eukaryotic organisms, are among the mos... Read More about Fructose-1,6-bisphosphate aldolase (FBA)-A conserved glycolytic enzyme with virulence functions in bacteria: 'Ill met by moonlight'.

TAp73 promotes anabolism (2014)
Journal Article
Amelio, I., Antonov, A. A., Catani, M. V., Massoud, R., Bernassola, F., Knight, R. A., …Rufini, A. (2014). TAp73 promotes anabolism. Oncotarget, 5(24), 12820-12834. https://doi.org/10.18632/oncotarget.2667

Metabolic adaptation has emerged as a hallmark of cancer and a promising therapeutic target, as rapidly proliferating cancer cells adapt their metabolism increasing nutrient uptake and reorganizing metabolic fluxes to support biosynthesis. The transc... Read More about TAp73 promotes anabolism.

Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide (2014)
Journal Article
Wong, P. S., Roberts, R. E., & Randall, M. D. (2015). Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide. Pharmacological Research, 91, https://doi.org/10.1016/j.phrs.2014.11.001

Oxygenation with 95%O2is routinely used in organ bath studies. However, hyperoxia may affect tissueresponses, particularly in studies which involve reactive oxygen species (ROS). Here, the effects of theantioxidant, Tiron, were investigated under dif... Read More about Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide.

Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1 (2014)
Journal Article
Noyes, H., Githiori, J., Bradley, J. E., Kemp, S., & Behnke, J. M. (2015). Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1. Parasitology, 142(4), https://doi.org/10.1017/S0031182014001644

Resistance to infections with Heligmosomoides bakeri is associated with a significant quantitative trait locus (QTL–Hbnr1) on mouse chromosome 1 (MMU1). We exploited recombinant mice, with a segment of MMU1 from susceptible C57Bl/10 mice introgressed... Read More about Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1.