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Combining two-directional synthesis and tandem reactions. Part 21: Exploitation of a dimeric macrocycle for chain terminus differentiation and synthesis of an sp3-rich library (2014)
Journal Article
Storr, T. E., Cully, S. J., Rawling, M. J., Lewis, W., Hamza, D., Jones, G., & Stockman, R. A. (2015). Combining two-directional synthesis and tandem reactions. Part 21: Exploitation of a dimeric macrocycle for chain terminus differentiation and synthesis of an sp3-rich library. Bioorganic and Medicinal Chemistry, 23(11), https://doi.org/10.1016/j.bmc.2014.12.050

The application of a tandem condensation/cyclisation/[3+2]-cycloaddition/elimination reaction gives an sp3-rich tricyclic pyrazoline scaffold with two ethyl esters in a single step from a simple linear starting material. The successive hydrolysis and... Read More about Combining two-directional synthesis and tandem reactions. Part 21: Exploitation of a dimeric macrocycle for chain terminus differentiation and synthesis of an sp3-rich library.

Thymine functionalised porphyrins, synthesis and heteromolecular surface-based self-assembly (2014)
Journal Article
Slater, A. G., Hu, Y., Yang, L., Argent, S. P., Lewis, W., Blunt, M. O., & Champness, N. R. (in press). Thymine functionalised porphyrins, synthesis and heteromolecular surface-based self-assembly. RSC Advances, 6, https://doi.org/10.1039/C4SC03531C

The synthesis and surface-based self-assembly of thymine-functionalised porphyrins is described. Reaction of 1-formylphenyl-3-benzoyl-thymine with suitable pyrollic species leads to the formation of tetra-(phenylthymine)porphyrin (tetra-TP) or mono-t... Read More about Thymine functionalised porphyrins, synthesis and heteromolecular surface-based self-assembly.

Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate (2014)
Journal Article
Schwehm, C., Lewis, W., Blake, A. J., Kellam, B., & Stocks, M. J. (2014). Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate. Acta Crystallographica Section C: Structural Chemistry, 70(12), 1161-1168. https://doi.org/10.1107/s205322961402436x

Bicycle ring closure on a mixture of (4aS,8aR)- and (4aR,8aS)-ethyl 2-oxodecahydro-1,6-naphthyridine-6-carboxylate, followed by conversion of the separated cis and trans isomers to the corresponding thioamide derivatives, gave (4aSR,8aRS)-ethyl 2-sul... Read More about Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate.

Switching intermolecular interactions by confinement in carbon nanotubes (2014)
Journal Article
Chamberlain, T., Lebedeva, M., Abuajwa, W., Suyetin, M., Lewis, W., Bichoutskaia, E., …Khlobystov, A. N. (2015). Switching intermolecular interactions by confinement in carbon nanotubes. Chemical Communications, 51(4), 648-651. https://doi.org/10.1039/c4cc08029g

The encapsulation of trityl-functionalised C60 molecules inside carbon nanotubes drastically affects the intermolecular interactions for this species. Whilst the orientations of molecules in the crystal are often controlled by thermodynamics, the mol... Read More about Switching intermolecular interactions by confinement in carbon nanotubes.

A Robust Binary Supramolecular Organic Framework (SOF) with High CO2 Adsorption and Selectivity (2014)
Journal Article
Lü, J., Perez-Krap, C., Suyetin, M., Alsmail, N. H., Yan, Y., Yang, S., …Schröder, M. (2014). A Robust Binary Supramolecular Organic Framework (SOF) with High CO2 Adsorption and Selectivity. Journal of the American Chemical Society, 136(37), 12828-12831. https://doi.org/10.1021/ja506577g

A robust binary hydrogen-bonded supramolecular organic framework (SOF-7) has been synthesized by solvothermal reaction of 1,4-bis-(4-(3,5-dicyano-2,6 dipyridyl)dihydropyridyl)benzene (1) and 5,5’-bis-(azanediyl)-oxalyl-diisophthalic acid (2). Single... Read More about A Robust Binary Supramolecular Organic Framework (SOF) with High CO2 Adsorption and Selectivity.

Isolation of stable non cyclic 1,2-disulfoxides: revisiting the thermolysis of S-aryl sulfinimines (2014)
Journal Article
Souto, J. A., Lewis, W., & Stockman, R. A. (2014). Isolation of stable non cyclic 1,2-disulfoxides: revisiting the thermolysis of S-aryl sulfinimines. Chemical Communications, 50(84), https://doi.org/10.1039/c4cc05751a

The thermolysis of S-aryl sulfinimines is shown to generate 1,2-disulfoxides and disulfides via initial Cope elimination, dimerisation of the produced sulfenic acid to a thiosulfinate, and subsequent disproportionation of the thiosulfinate.

Two-Electron Reductive Carbonylation of Terminal Uranium(V) and Uranium(VI) Nitrides to Cyanate by Carbon Monoxide (2014)
Journal Article
Cleaves, P. A., King, D. M., Kefalidis, C. E., Maron, L., Tuna, F., McInnes, E. J., …Liddle, S. T. (2014). Two-Electron Reductive Carbonylation of Terminal Uranium(V) and Uranium(VI) Nitrides to Cyanate by Carbon Monoxide. Angewandte Chemie International Edition, 53(39), 10412-10415. https://doi.org/10.1002/anie.201406203

Two-electron reductive carbonylation of the uranium(VI) nitride [U(TrenTIPS)(N)] (2, TrenTIPS=N(CH2CH2NSiiPr3)3) with CO gave the uranium(IV) cyanate [U(TrenTIPS)(NCO)] (3). KC8 reduction of 3 resulted in cyanate dissociation to give [U(TrenTIPS)] (4... Read More about Two-Electron Reductive Carbonylation of Terminal Uranium(V) and Uranium(VI) Nitrides to Cyanate by Carbon Monoxide.

The Ketimide Ligand is Not Just an Inert Spectator: Heteroallene Insertion Reactivity of an Actinide-Ketimide Linkage in a Thorium Carbene Amide Ketimide Complex (2014)
Journal Article
Lu, E., Lewis, W., Blake, A. J., & Liddle, S. T. (2014). The Ketimide Ligand is Not Just an Inert Spectator: Heteroallene Insertion Reactivity of an Actinide-Ketimide Linkage in a Thorium Carbene Amide Ketimide Complex. Angewandte Chemie International Edition, 53(35), 9356-9359. https://doi.org/10.1002/anie.201404898

The ketimide anion R2C[DOUBLE BOND]N? is an important class of chemically robust ligand that binds strongly to metal ions and is considered ideal for supporting reactive metal fragments due to its inert spectator nature; this contrasts with R2N? amid... Read More about The Ketimide Ligand is Not Just an Inert Spectator: Heteroallene Insertion Reactivity of an Actinide-Ketimide Linkage in a Thorium Carbene Amide Ketimide Complex.

1,4-addition of TMSCCl3to nitroalkenes: efficient reaction conditions and mechanistic understanding (2014)
Journal Article
Wu, N., Wahl, B., Woodward, S., & Lewis, W. (2014). 1,4-addition of TMSCCl3to nitroalkenes: efficient reaction conditions and mechanistic understanding. Chemistry - A European Journal, 20(25), https://doi.org/10.1002/chem.201402394

Improved synthetic conditions allow preparation of TMSCCl3 in good yield (70 %) and excellent purity. Compounds of the type NBu4X [X=Ph3SiF2 (TBAT), F (tetrabutylammonium fluoride, TBAF), OAc, Cl and Br] act as catalytic promoters for 1,4-additions t... Read More about 1,4-addition of TMSCCl3to nitroalkenes: efficient reaction conditions and mechanistic understanding.

Synthesis, Characterization, and Reactivity of a Uranium(VI) Carbene Imido Oxo Complex (2014)
Journal Article
Lu, E., Cooper, O. J., McMaster, J., Tuna, F., McInnes, E. J., Lewis, W., …Liddle, S. T. (2014). Synthesis, Characterization, and Reactivity of a Uranium(VI) Carbene Imido Oxo Complex. Angewandte Chemie International Edition, 53(26), 6696-6700. https://doi.org/10.1002/anie.201403892

We report the uranium(VI) carbene imido oxo complex [U(BIPMTMS)(NMes)(O)(DMAP)2] (5, BIPMTMS=C(PPh2NSiMe3)2; Mes=2,4,6-Me3C6H2; DMAP=4-(dimethylamino)pyridine) which exhibits the unprecedented arrangement of three formal multiply bonded ligands to on... Read More about Synthesis, Characterization, and Reactivity of a Uranium(VI) Carbene Imido Oxo Complex.

A Novel Bismuth-Based Metal-Organic Framework for High Volumetric Methane and Carbon Dioxide Adsorption (2014)
Journal Article
Savage, M., Yang, S., Suyetin, M., Bichoutskaia, E., Lewis, W., Blake, A. J., …Schröder, M. (2014). A Novel Bismuth-Based Metal-Organic Framework for High Volumetric Methane and Carbon Dioxide Adsorption. Chemistry - A European Journal, 20(26), 8024-8029. https://doi.org/10.1002/chem.201304799

Solvothermal reaction of H4L (L = biphenyl-3,3’,5,5’-tetracarboxylate) and Bi(NO3)3·(H2O)5 in a mixture of DMF/MeCN/H2O in the presence of piperazine and nitric acid at 100 oC for 10 h affords the solvated metal-organic polymer [Bi2(L)1.5(H2O)2]·(DMF... Read More about A Novel Bismuth-Based Metal-Organic Framework for High Volumetric Methane and Carbon Dioxide Adsorption.

Analysis of High and Selective Uptake of CO2in an Oxamide-Containing {Cu2(OOCR)4}-Based Metal-Organic Framework (2014)
Journal Article
Alsmail, N. H., Suyetin, M., Yan, Y., Cabot, R., Krap, C. P., Lü, J., …Schröder, M. (2014). Analysis of High and Selective Uptake of CO2in an Oxamide-Containing {Cu2(OOCR)4}-Based Metal-Organic Framework. Chemistry - A European Journal, 20(24), 7317-7324. https://doi.org/10.1002/chem.201304005

The porous framework [Cu2(H2O)2L].4H2O.2DMA ((H¬4¬L = oxalylbis(azanediyl)diisophthalic acid; DMA = N,N-dimethylacetamide), denoted NOTT-125, is formed by connection of {Cu2(RCOO)4} paddlewheels with the isophthalate linkers in L4-. A single crystal... Read More about Analysis of High and Selective Uptake of CO2in an Oxamide-Containing {Cu2(OOCR)4}-Based Metal-Organic Framework.

Ligand influences on homoleptic Group 12 m-terphenyl complexes (2014)
Journal Article
Blundell, T. J., Hastings, F. R., Gridley, B. M., Moxey, G. J., Blake, A. J., Lewis, W., & Kays, D. L. (2014). Ligand influences on homoleptic Group 12 m-terphenyl complexes. Dalton Transactions, 43, https://doi.org/10.1039/C4DT00647J

Three m-terphenyl ligands 2,6-Ar2C6H3 – [Ar = 2,6-Me2C6H3 (2,6-Xyl); 3,5-Me2C6H3 (3,5-Xyl); 2,3,4,5,6-Me5C6 (Pmp)] have been used to stabilise three series of two-coordinate Group 12 diaryl complexes; (2,6-Ar2C6H3)2M [M = Zn, Cd, Hg; Ar = 2,6-Xyl 1-3... Read More about Ligand influences on homoleptic Group 12 m-terphenyl complexes.

Synthesis and Characterization of an f-Block Terminal Parent Imido [U?NH] Complex: A Masked Uranium(IV) Nitride (2014)
Journal Article
King, D. M., McMaster, J., Tuna, F., McInnes, E. J., Lewis, W., Blake, A. J., & Liddle, S. T. (2014). Synthesis and Characterization of an f-Block Terminal Parent Imido [U?NH] Complex: A Masked Uranium(IV) Nitride. Journal of the American Chemical Society, 136(15), 5619-5622. https://doi.org/10.1021/ja502405e

Deprotonation of [U(TrenTIPS)(NH2)] (1) [TrenTIPS = N(CH2CH2NSiPri3)3] with organoalkali metal reagents MR (M = Li, R = But; M = Na?Cs, R = CH2C6H5) afforded the imido-bridged dimers [{U-(TrenTIPS)(?-N[H]M)}2] [M = L ?Cs (2a?e)]. Treatmentof 2c (M =... Read More about Synthesis and Characterization of an f-Block Terminal Parent Imido [U?NH] Complex: A Masked Uranium(IV) Nitride.

Triamidoamine-Uranium(IV)-Stabilized Terminal Parent Phosphide and Phosphinidene Complexes (2014)
Journal Article
Gardner, B. M., Balázs, G., Scheer, M., Tuna, F., McInnes, E. J., McMaster, J., …Liddle, S. T. (2014). Triamidoamine-Uranium(IV)-Stabilized Terminal Parent Phosphide and Phosphinidene Complexes. Angewandte Chemie International Edition, 53(17), 4484-4488. https://doi.org/10.1002/anie.201400798

Reaction of [U(TrenTIPS)(THF)][BPh4] (1; TrenTIPS=N{CH2CH2NSi(iPr)3}3) with NaPH2 afforded the novel f-block terminal parent phosphide complex [U(TrenTIPS)(PH2)] (2; U–P=2.883(2) Å). Treatment of 2 with one equivalent of KCH2C6H5 and two equivalents... Read More about Triamidoamine-Uranium(IV)-Stabilized Terminal Parent Phosphide and Phosphinidene Complexes.

The role of 5f-orbital participation in unexpected inversion of the ?-bond metathesis reactivity trend of triamidoamine thorium(iv) and uranium(iv) alkyls (2014)
Journal Article
Gardner, B. M., Cleaves, P. A., Kefalidis, C. E., Fang, J., Maron, L., Lewis, W., …Liddle, S. T. (2014). The role of 5f-orbital participation in unexpected inversion of the σ-bond metathesis reactivity trend of triamidoamine thorium(iv) and uranium(iv) alkyls. Chemical Science, 5(6), 2489-2497. https://doi.org/10.1039/c4sc00182f

We report on the role of 5f-orbital participation in the unexpected inversion of the σ-bond metathesis reactivity trend of triamidoamine thorium(IV) and uranium(IV) alkyls. Reaction of KCH2Ph with [U(TrenTIPS)(I)] [2a, TrenTIPS = N(CH2CH2NSiPri3)33−]... Read More about The role of 5f-orbital participation in unexpected inversion of the ?-bond metathesis reactivity trend of triamidoamine thorium(iv) and uranium(iv) alkyls.

Synthesis of toxyloxanthone B (2014)
Journal Article
Giallombardoa, D., Nevin, A. C., Lewis, W., Nawrat, C. C., Kitson, R. R., & Moody, C. J. (2014). Synthesis of toxyloxanthone B. Tetrahedron, 70(6), https://doi.org/10.1016/j.tet.2013.12.055

A synthesis of the naturally occurring xanthone toxyloxanthone B is described, in which the key step is the regioselective addition of a methyl salicylate to a substituted benzyne followed by cyclization of the intermediate aryl anion to form the xan... Read More about Synthesis of toxyloxanthone B.