All Outputs (3)

A 2-year randomised placebo-controlled trial of doxycycline for lymphangioleiomyomatosis (2014)
Journal Article
Chang, W. Y., Cane, J. L., Kumaran, M., Lewis, S., Tattersfield, A. E., & Johnson, S. R. (2014). A 2-year randomised placebo-controlled trial of doxycycline for lymphangioleiomyomatosis. European Respiratory Journal, 43(4), https://doi.org/10.1183/09031936.00167413

Lymphangioleiomyomatosis (LAM) is characterised by lung cysts and airflow obstruction. Matrix metalloproteinases have been implicated in lung destruction in LAM. We performed a randomised, double-blind trial, comparing the matrix metalloproteinases i... Read More about A 2-year randomised placebo-controlled trial of doxycycline for lymphangioleiomyomatosis.

The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model (2014)
Journal Article
Chernyavsky, I. L., Croisier, H., Chapman, L. A., Kimpton, L. S., Hiorns, J. E., Brook, B., …Johnson, S. R. (2014). The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model. PLoS ONE, 9(3), Article e90162. https://doi.org/10.1371/journal.pone.0090162

Despite a large amount of in vitro data, the dynamics of airway smooth muscle (ASM) mass increase in the airways of patients with asthma is not well understood. Here, we present a novel mathematical model that describes qualitatively the growth dynam... Read More about The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model.

Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma (2014)
Journal Article
Rogers, N. K., Clements, D., Dongre, A., Harrison, T. W., Shaw, D. E., & Johnson, S. R. (2014). Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma. PLoS ONE, 9(2), Article e90565. https://doi.org/10.1371/journal.pone.0090565

Airway remodelling describes the histopathological changes leading to fixed airway obstruction in patients with asthma and includes extra-cellular matrix (ECM) deposition. Matrix metalloproteinase-1 (MMP-1) is present in remodelled airways but its re... Read More about Extra-Cellular Matrix Proteins Induce Matrix Metalloproteinase-1 (MMP-1) Activity and Increase Airway Smooth Muscle Contraction in Asthma.